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Command Line Tools for High-Throughput Parallel GSEA Analysis

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GSEAsh

Overview

These scripts offer various functionalities for running GSEA, obtaining database metadata, and processing results. The initial version includes the following features:

  • Memory Management: Automatically adjusts to the user's memory capacity, enabling simultaneous GSEA analysis for multiple comparisons. Adapted from the GSEA User Guide.
  • Gene Set Consistency Check: Verifies that all analyses use the same gene sets and quantities.
  • Results Merging: Combines GSEA result TSV files from different comparisons into a single file.
  • Gene Set Retrieval: Downloads GRP files for selected gene sets from the Molecular Signatures Database (MSigDB).
  • Gene Consolidation: Generates a data frame with genes in one column and their source gene sets in another, facilitating gene tracking and screening.

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