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<p style="font-size:115%;">Welcome to the AsthmaMap project, a community-driven effort focused on a comprehensive description of asthma mechanisms and its applications for developing models, data interpretation and hypothesis generation.</p>

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<a href="https://asthma.uni.lu/minerva/"><img src="/images/buttons/openinminerva.png" alt="Open in MINERVA" width="200" target="_blank"></a> &nbsp; &nbsp; &nbsp;
<a href="/tutorials"><img src="/images/buttons/videotutorialsclear2.png" alt="Video tutorials" width="200" target="_blank"></a>
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<!--<p><a href="https://asthma.uni.lu/minerva/" target="_blank">Open in MINERVA</a> to browse the AsthmaMap Build 1.2. More information about the MINERVA platform is available in Tools.</p>
<p><a href="../tutorials">Video tutorials</a> are available on browsing the AsthmaMap in MINERVA and using the resource for drug target exploration and data visualisation.</p>-->

<h2>AsthmaMap architecture</h2>

<p>The AsthmaMap includes three interconnected layers of granularity: Cellular Interactions (CI), a high-level overview; Molecular Relations (MR), the intermediate level of details; Biochemical Mechanisms (BM), the most detailed layer.</p>

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  <td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/ci"><strong>AsthmaMap Cellular Interactions</strong></a></td>
  <td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/mr"><strong>AsthmaMap Molecular Relations</strong></a></td>
  <td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/bm"><strong>AsthmaMap Biochemical Mechanisms</strong></a></td>
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  <td style="width: 300px; text-align: center;"><a href="/ci"><img src="/images/layers/new-CI-cut.jpg" width="270" style="border:1px solid grey"/></a></td>
  <td style="width: 300px; text-align: center;"><a href="/mr"><img src="/images/layers/F002-AirwayEpithelialCell-cut.png" width="270" style="border:1px solid grey"/></a></td>
  <td style="width: 300px; text-align: center;"><a href="/bm"><img src="/images/layers/new-PD-cut.jpg" width="270" style="border:1px solid grey"/></a></td>
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  <td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> cell-to-cell communication, each receptor represents the corresponding pathway of the AF and PD layers.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> activity flows.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> disease overview, defining the content for the detailed maps, disease endotype visualisation.</p><p style="margin:10px; font-size:14px"><strong>Compatible databeses:</strong> MetaCore Pathway Maps (overview type).</p></td>
  <td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> compact representation of signalling events, molecular interactions without details on processes.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> activity flows.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> ‘omics visualisation, network-enrichment analysis, interpretation and hypothesis generation, logical models.</p><p style="margin:10px; font-size:14px"><strong>Compatible databeses:</strong> MetaCore Pathway Maps, Ingenuity Pathways Knowledge Base, KEGG Pathway Database.</p></td>
  <td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> comprehensive detailed maps - integrated detailed metabolic, signalling and gene regulatory pathways.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> process descriptions.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> unambiguous visualisation of molecular processes, the basis for modelling and simulation.</p><p style="margin:10px; font-size:14px"><strong>Compatible databases:</strong> Reactome Pathway Database, PANTHER Pathways, Recon2 reconstruction of human metabolism.</p></td>
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