diff --git a/megaavr/variants/txy2/pins_arduino.h b/megaavr/variants/txy2/pins_arduino.h
index 7250d1c5..b5b2fc27 100644
--- a/megaavr/variants/txy2/pins_arduino.h
+++ b/megaavr/variants/txy2/pins_arduino.h
@@ -40,10 +40,12 @@
 
 #define digitalPinHasPWM(p)         ((p) != 0 && (p) != 5)
 
+#ifdef PORTMUX_SPI0_bm
 #define PIN_SPI_MISO_PINSWAP_1 	(1)
 #define PIN_SPI_SCK_PINSWAP_1 		(4)
 #define PIN_SPI_MOSI_PINSWAP_1 	(0)
 #define PIN_SPI_SS_PINSWAP_1 		(0)
+#endif
 #define PIN_SPI_MISO	(3)
 #define PIN_SPI_SCK		(4)
 #define PIN_SPI_MOSI	(2)
diff --git a/megaavr/variants/txy4/pins_arduino.h b/megaavr/variants/txy4/pins_arduino.h
index 51cac7c2..692673c7 100644
--- a/megaavr/variants/txy4/pins_arduino.h
+++ b/megaavr/variants/txy4/pins_arduino.h
@@ -49,8 +49,10 @@
 
 
 
+#ifdef PORTMUX_TWI0_bm
 #define PIN_WIRE_SDA_PINSWAP_1        (8)
 #define PIN_WIRE_SCL_PINSWAP_1        (9)
+#endif
 #define PIN_WIRE_SDA        (6)
 #define PIN_WIRE_SCL        (7)
 
diff --git a/megaavr/variants/txy6/pins_arduino.h b/megaavr/variants/txy6/pins_arduino.h
index f8d7fe36..8832f2dc 100644
--- a/megaavr/variants/txy6/pins_arduino.h
+++ b/megaavr/variants/txy6/pins_arduino.h
@@ -47,18 +47,22 @@
 #define PIN_SPI_SCK		(16)
 #define PIN_SPI_MOSI	(14)
 #define PIN_SPI_SS		(0)
+#ifdef PORTMUX_SPI0_bm
 #define PIN_SPI_MISO_PINSWAP_1  (11)
 #define PIN_SPI_SCK_PINSWAP_1   (10)
 #define PIN_SPI_MOSI_PINSWAP_1  (12)
 #define PIN_SPI_SS_PINSWAP_1    (13)
+#endif
 
 #define SPI_INTERFACES_COUNT	1
 
 
-#define PIN_WIRE_SDA        (14)
-#define PIN_WIRE_SCL        (15)
-#define PIN_WIRE_SDA_PINSWAP_1        (8)
-#define PIN_WIRE_SCL_PINSWAP_1        (9)
+#define PIN_WIRE_SDA        (8)
+#define PIN_WIRE_SCL        (9)
+#ifdef PORTMUX_TWI0_bm
+#define PIN_WIRE_SDA_PINSWAP_1        (14)
+#define PIN_WIRE_SCL_PINSWAP_1        (15)
+#endif
 
 
 //Define the pin names, since user code may depend on them, even though the core libraries don't...
diff --git a/megaavr/variants/txy7/pins_arduino.h b/megaavr/variants/txy7/pins_arduino.h
index ea6b5dee..ff7b022b 100644
--- a/megaavr/variants/txy7/pins_arduino.h
+++ b/megaavr/variants/txy7/pins_arduino.h
@@ -41,10 +41,12 @@
 #define digitalPinHasPWM(p)         ((p) == 0 || (p) == 1 || (p) == 11 || (p) == 10 || (p) == 9 || (p) == 20)
 #endif
 
+#ifdef PORTMUX_SPI0_bm
 #define PIN_SPI_MISO_PINSWAP_1    (13)
 #define PIN_SPI_SCK_PINSWAP_1        (12)
 #define PIN_SPI_MOSI_PINSWAP_1    (14)
 #define PIN_SPI_SS_PINSWAP_1        (15)
+#endif
 #define PIN_SPI_MISO    (19)
 #define PIN_SPI_SCK        (20)
 #define PIN_SPI_MOSI    (18)
@@ -52,8 +54,10 @@
 
 #define SPI_INTERFACES_COUNT    1
 
+#ifdef PORTMUX_TWI0_bm
 #define PIN_WIRE_SDA_PINSWAP_1        (18)
 #define PIN_WIRE_SCL_PINSWAP_1        (19)
+#endif
 #define PIN_WIRE_SDA        (10)
 #define PIN_WIRE_SCL        (11)