From 1280eecd3557c15614a0a10a3f421c1fba825ae7 Mon Sep 17 00:00:00 2001
From: GuyTeichman <48219633+GuyTeichman@users.noreply.github.com>
Date: Fri, 9 Jun 2023 19:24:18 +0300
Subject: [PATCH] updated docs for V3.9.0

---
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 364 files changed, 7573 insertions(+), 1732 deletions(-)
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.CountFilter.save_parquet.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.CountFilter.save_table.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.DESeqFilter.save_parquet.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.DESeqFilter.save_table.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.Filter.save_parquet.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.Filter.save_table.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.FoldChangeFilter.save_parquet.doctree
 create mode 100644 docs/build/.doctrees/rnalysis.filtering.FoldChangeFilter.save_table.doctree
 create mode 100644 docs/build/_sources/rnalysis.filtering.CountFilter.save_parquet.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.CountFilter.save_table.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.DESeqFilter.save_parquet.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.DESeqFilter.save_table.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.Filter.save_parquet.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.Filter.save_table.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_parquet.rst.txt
 create mode 100644 docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_table.rst.txt
 create mode 100644 docs/build/rnalysis.filtering.CountFilter.save_parquet.html
 create mode 100644 docs/build/rnalysis.filtering.CountFilter.save_table.html
 create mode 100644 docs/build/rnalysis.filtering.DESeqFilter.save_parquet.html
 create mode 100644 docs/build/rnalysis.filtering.DESeqFilter.save_table.html
 create mode 100644 docs/build/rnalysis.filtering.Filter.save_parquet.html
 create mode 100644 docs/build/rnalysis.filtering.Filter.save_table.html
 create mode 100644 docs/build/rnalysis.filtering.FoldChangeFilter.save_parquet.html
 create mode 100644 docs/build/rnalysis.filtering.FoldChangeFilter.save_table.html
 create mode 100644 docs/source/rnalysis.filtering.CountFilter.save_parquet.rst
 create mode 100644 docs/source/rnalysis.filtering.CountFilter.save_table.rst
 create mode 100644 docs/source/rnalysis.filtering.DESeqFilter.save_parquet.rst
 create mode 100644 docs/source/rnalysis.filtering.DESeqFilter.save_table.rst
 create mode 100644 docs/source/rnalysis.filtering.Filter.save_parquet.rst
 create mode 100644 docs/source/rnalysis.filtering.Filter.save_table.rst
 create mode 100644 docs/source/rnalysis.filtering.FoldChangeFilter.save_parquet.rst
 create mode 100644 docs/source/rnalysis.filtering.FoldChangeFilter.save_table.rst

diff --git a/HISTORY.rst b/HISTORY.rst
index 2df4aa9b..77efe47d 100644
--- a/HISTORY.rst
+++ b/HISTORY.rst
@@ -13,13 +13,13 @@ and addresses multiple bug fixes, including issues with automatic session report
 Added
 *******
 * Added additional parameters to enrichment bar plots (enrichment.enrichment_bar_plot), including a new plot style ('lollipop') and observed/expected labels on the graph.
-* Added new parameter to Principal Component Analysis plots (CountFilter.pca) 'plot_grid', which can enable or disable adding a grid to PCA plots.
+* Added a new parameter to Principal Component Analysis plots (CountFilter.pca) 'plot_grid', which can enable or disable adding a grid to PCA plots.
 * RNAlysis can now load and save data tables in Parquet format (.parquet)
 * Added new actions to the Help menu, allowing users to report issues, suggest issues, or open discussions.
 
 Changed
 ********
-* Functions in the FASTQ model are now added to automatic session report.
+* Functions in the FASTQ model are now added to automatic session reports.
 * Many of the functions in RNAlysis should now run faster.
 * Font type, size, and color for help tooltips should now match the global font settings.
 * True/False toggle switches now scale with font size.
diff --git a/docs/build/.buildinfo b/docs/build/.buildinfo
index f28187ec..a92a4d22 100644
--- a/docs/build/.buildinfo
+++ b/docs/build/.buildinfo
@@ -1,4 +1,4 @@
 # Sphinx build info version 1
 # This file hashes the configuration used when building these files. When it is not found, a full rebuild will be done.
-config: 3c48e481a1029f13bde63990a1e048d4
+config: 2858b2fb37c09d1c89cf9b770d3cf048
 tags: 645f666f9bcd5a90fca523b33c5a78b7
diff --git a/docs/build/.doctrees/api_reference.doctree b/docs/build/.doctrees/api_reference.doctree
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diff --git a/docs/build/.doctrees/index.doctree b/docs/build/.doctrees/index.doctree
index 9586b0b1b07c3e24d9ea913437d968e80ebb7701..11bd69a1ee0045d9fad2ed205bb03f2c26c49c62 100644
GIT binary patch
delta 16
XcmZ3}$GE1Cal?FOM$63$n0uT7H|_=~

delta 16
XcmZ3}$GE1Cal?FOMvKi0n0uT7H|Pc@

diff --git a/docs/build/.doctrees/readme.doctree b/docs/build/.doctrees/readme.doctree
index cff321e17a70e71dfa819e04230f71e49102400c..538e9b5d368b1ce1db4a9a7d25cc9a986ac9f4d0 100644
GIT binary patch
delta 1284
zcmZ8fTTD|~6lGuRMINo9(xB3*kE)=c;EX!PR579^Y8rgS_`#z}!|j!!idN%?VJ2a0
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delta 969
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diff --git a/docs/build/.doctrees/rnalysis.doctree b/docs/build/.doctrees/rnalysis.doctree
index 0d8de263809a6b147f03e9b39cf037f07263d0cb..0f3ebdfeb2a8218b45ab20e9ff9b16cdd29f211c 100644
GIT binary patch
delta 629208
zcmbTfcVJaT^FPelOG!v>OCSj)A)%&_kU&5>2^|qgKoOA^Y6vYL2q;|;6_7xH1*M82
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.go_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.go_enrichment.doctree
index e5807dc13773be507bda297d2c729a47e7657555..21fb1d49982354901e287a817d88b77fa197f7a8 100644
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.kegg_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.kegg_enrichment.doctree
index 8b67f8872f5af9ba0a7bb1f298100cc506cc61d3..38a4d8d1369a108d0feb67f53808394104d439dd 100644
GIT binary patch
delta 12501
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.user_defined_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.FeatureSet.user_defined_enrichment.doctree
index 50a7581dc7fa282ba29f84a90b1ae1b3ef8e03ef..bfa601443d3b5d9480ad4603442e3176e679b0d6 100644
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.go_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.go_enrichment.doctree
index 48d749d8c5998f96d1016724f570b10c9ecf278d..aae28e5c84641d98de84bc3d741d52e9cb1b04f5 100644
GIT binary patch
delta 12534
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.kegg_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.kegg_enrichment.doctree
index 05eb932a2030b4732f44c12d2c2565478b9a78b2..9e146de252ab5d09f5c758a2c095c04726badf3d 100644
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_enrichment.doctree
index eac0b0eb61d73b445f4c3e94b8e1a822f43f96f3..d2594db7330e6dbf213d42b5c413cff7db1c13ef 100644
GIT binary patch
delta 6770
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_go_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_go_enrichment.doctree
index 8b46a966cdfdde0ba9a3195fd13bd34dff952f47..a8e51526282a1f6f1c2545b00b376f2d937bdf61 100644
GIT binary patch
delta 10174
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_kegg_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.single_set_kegg_enrichment.doctree
index 1cd6c4a07b6eeb3f178cb7a3e798e863243a4ff3..f9a4dbb9f7bbff09d8b8f35677ba133adf54555c 100644
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.RankedSet.user_defined_enrichment.doctree b/docs/build/.doctrees/rnalysis.enrichment.RankedSet.user_defined_enrichment.doctree
index e5ee6a6591fa62f2a0b1d1a9c0f7b0a108e2d2b8..d4e0a516a547151adc1a2ed67f397d885af5ca45 100644
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diff --git a/docs/build/.doctrees/rnalysis.enrichment.enrichment_bar_plot.doctree b/docs/build/.doctrees/rnalysis.enrichment.enrichment_bar_plot.doctree
index fb9dce4c2a7e8143cf01e874d0a33c6407e93522..173029c5e4b6b60c313da420e20d442d8991337e 100644
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delta 3903
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diff --git a/docs/build/.doctrees/rnalysis.fastq.PairedEndPipeline.doctree b/docs/build/.doctrees/rnalysis.fastq.PairedEndPipeline.doctree
index 457035474ec819dd641e585b47f920edda3962f3..2bc132251d8f6d0a8c73ab29bc22b699d498888c 100644
GIT binary patch
delta 85
zcmdm$d?J~pfpzNMjVx>&jP;WRS&VE-OEPncW71ReQj0Q^^$IGjQu33FONuh{(iQU4
c6pHc^b1I87i}k?D^kB-|A<8#rbNFil07a%Bf&c&j

delta 28
kcmX?+yepZdfpzNojVx>&jD?d0Su!TuadL0&;jqyJ0Fpom>;M1&

diff --git a/docs/build/.doctrees/rnalysis.fastq.SingleEndPipeline.doctree b/docs/build/.doctrees/rnalysis.fastq.SingleEndPipeline.doctree
index 5f32e33628656c8fc7025e3065e4bdb764dbe405..309a5cdfc0bf84834f99b5e0c42c10dfa995c6c7 100644
GIT binary patch
delta 85
zcmX?=d?T5qfpzNHjVx>&jP;WRS&VE-OEPncW71ReQj0Q^^$IGjQu33FONuh{(iQU4
c6pHc^b1I87i}k?D^kB-|A<8#rbHr-`096(r!T<mO

delta 28
kcmcbSd@7lxfpzNsjVx>&jD?d0Su!TuadL0&;qcJ}0G9v>EC2ui

diff --git a/docs/build/.doctrees/rnalysis.filtering.CountFilter.doctree b/docs/build/.doctrees/rnalysis.filtering.CountFilter.doctree
index c1f4071f3b31c49ba5bd10372f3fa5728eefb0b8..632c4120920d7de3ea77e34f51780b72aab5ab20 100644
GIT binary patch
delta 4361
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delta 3591
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diff --git a/docs/build/.doctrees/tutorial.doctree b/docs/build/.doctrees/tutorial.doctree
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diff --git a/docs/build/_sources/rnalysis.filtering.CountFilter.rst.txt b/docs/build/_sources/rnalysis.filtering.CountFilter.rst.txt
index db8c5bac..fed55fcb 100644
--- a/docs/build/_sources/rnalysis.filtering.CountFilter.rst.txt
+++ b/docs/build/_sources/rnalysis.filtering.CountFilter.rst.txt
@@ -1,4 +1,4 @@
-rnalysis.filtering.CountFilter
+rnalysis.filtering.CountFilter
 ==============================
 
 .. currentmodule:: rnalysis.filtering
@@ -62,6 +62,8 @@ rnalysis.filtering.CountFilter
     CountFilter.plot_expression
     CountFilter.print_features
     CountFilter.save_csv
+    CountFilter.save_parquet
+    CountFilter.save_table
     CountFilter.scatter_sample_vs_sample
     CountFilter.sort
     CountFilter.split_by_attribute
diff --git a/docs/build/_sources/rnalysis.filtering.CountFilter.save_parquet.rst.txt b/docs/build/_sources/rnalysis.filtering.CountFilter.save_parquet.rst.txt
new file mode 100644
index 00000000..00e2b205
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.CountFilter.save_parquet.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.CountFilter.save\_parquet
+============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: CountFilter.save_parquet
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.CountFilter.save_table.rst.txt b/docs/build/_sources/rnalysis.filtering.CountFilter.save_table.rst.txt
new file mode 100644
index 00000000..7aa50788
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.CountFilter.save_table.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.CountFilter.save\_table
+==========================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: CountFilter.save_table
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.DESeqFilter.rst.txt b/docs/build/_sources/rnalysis.filtering.DESeqFilter.rst.txt
index 1b99dd11..656b060d 100644
--- a/docs/build/_sources/rnalysis.filtering.DESeqFilter.rst.txt
+++ b/docs/build/_sources/rnalysis.filtering.DESeqFilter.rst.txt
@@ -1,4 +1,4 @@
-rnalysis.filtering.DESeqFilter
+rnalysis.filtering.DESeqFilter
 ==============================
 
 .. currentmodule:: rnalysis.filtering
@@ -41,6 +41,8 @@ rnalysis.filtering.DESeqFilter
     DESeqFilter.number_filters
     DESeqFilter.print_features
     DESeqFilter.save_csv
+    DESeqFilter.save_parquet
+    DESeqFilter.save_table
     DESeqFilter.sort
     DESeqFilter.split_by_attribute
     DESeqFilter.split_by_percentile
diff --git a/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_parquet.rst.txt b/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_parquet.rst.txt
new file mode 100644
index 00000000..d1c56fee
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_parquet.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.DESeqFilter.save\_parquet
+============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: DESeqFilter.save_parquet
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_table.rst.txt b/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_table.rst.txt
new file mode 100644
index 00000000..60b8bc05
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.DESeqFilter.save_table.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.DESeqFilter.save\_table
+==========================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: DESeqFilter.save_table
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.Filter.rst.txt b/docs/build/_sources/rnalysis.filtering.Filter.rst.txt
index 9d19e05b..6c7829d7 100644
--- a/docs/build/_sources/rnalysis.filtering.Filter.rst.txt
+++ b/docs/build/_sources/rnalysis.filtering.Filter.rst.txt
@@ -1,4 +1,4 @@
-rnalysis.filtering.Filter
+rnalysis.filtering.Filter
 =========================
 
 .. currentmodule:: rnalysis.filtering
@@ -38,6 +38,8 @@ rnalysis.filtering.Filter
     Filter.number_filters
     Filter.print_features
     Filter.save_csv
+    Filter.save_parquet
+    Filter.save_table
     Filter.sort
     Filter.split_by_attribute
     Filter.split_by_percentile
diff --git a/docs/build/_sources/rnalysis.filtering.Filter.save_parquet.rst.txt b/docs/build/_sources/rnalysis.filtering.Filter.save_parquet.rst.txt
new file mode 100644
index 00000000..ba7cba54
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.Filter.save_parquet.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.Filter.save\_parquet
+=======================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: Filter.save_parquet
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.Filter.save_table.rst.txt b/docs/build/_sources/rnalysis.filtering.Filter.save_table.rst.txt
new file mode 100644
index 00000000..6687c006
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.Filter.save_table.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.Filter.save\_table
+=====================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: Filter.save_table
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.rst.txt b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.rst.txt
index 12df8225..b083a6b3 100644
--- a/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.rst.txt
+++ b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.rst.txt
@@ -1,4 +1,4 @@
-rnalysis.filtering.FoldChangeFilter
+rnalysis.filtering.FoldChangeFilter
 ===================================
 
 .. currentmodule:: rnalysis.filtering
@@ -41,6 +41,8 @@ rnalysis.filtering.FoldChangeFilter
     FoldChangeFilter.print_features
     FoldChangeFilter.randomization_test
     FoldChangeFilter.save_csv
+    FoldChangeFilter.save_parquet
+    FoldChangeFilter.save_table
     FoldChangeFilter.sort
     FoldChangeFilter.split_by_attribute
     FoldChangeFilter.split_by_percentile
diff --git a/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_parquet.rst.txt b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_parquet.rst.txt
new file mode 100644
index 00000000..b4926620
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_parquet.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.FoldChangeFilter.save\_parquet
+=================================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: FoldChangeFilter.save_parquet
\ No newline at end of file
diff --git a/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_table.rst.txt b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_table.rst.txt
new file mode 100644
index 00000000..ff9f1599
--- /dev/null
+++ b/docs/build/_sources/rnalysis.filtering.FoldChangeFilter.save_table.rst.txt
@@ -0,0 +1,6 @@
+rnalysis.filtering.FoldChangeFilter.save\_table
+===============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: FoldChangeFilter.save_table
\ No newline at end of file
diff --git a/docs/build/_static/documentation_options.js b/docs/build/_static/documentation_options.js
index 81a131a8..bbc53345 100644
--- a/docs/build/_static/documentation_options.js
+++ b/docs/build/_static/documentation_options.js
@@ -1,6 +1,6 @@
 var DOCUMENTATION_OPTIONS = {
     URL_ROOT: document.getElementById("documentation_options").getAttribute('data-url_root'),
-    VERSION: '3.8.0',
+    VERSION: '3.9.0',
     LANGUAGE: 'en',
     COLLAPSE_INDEX: false,
     BUILDER: 'html',
diff --git a/docs/build/api_reference.html b/docs/build/api_reference.html
index 9c261b41..7b547126 100644
--- a/docs/build/api_reference.html
+++ b/docs/build/api_reference.html
@@ -4,14 +4,14 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>API Reference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>API Reference &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
   <!--[if lt IE 9]>
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
-  
+
         <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
         <script src="_static/jquery.js"></script>
         <script src="_static/underscore.js"></script>
@@ -22,10 +22,10 @@
     <script src="_static/js/theme.js"></script>
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
-    <link rel="prev" title="Index" href="genindex.html" /> 
+    <link rel="prev" title="Index" href="genindex.html" />
 </head>
 
-<body class="wy-body-for-nav"> 
+<body class="wy-body-for-nav">
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -109,7 +109,7 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-             
+
   <section id="api-reference">
 <h1>API Reference<a class="headerlink" href="#api-reference" title="Permalink to this heading"></a></h1>
 <div class="admonition warning">
@@ -146,12 +146,6 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">_is_paired_end</span></span></dt>
-<dd><p>indicates whether it is single-end or paired-end Pipeline</p>
-</dd></dl>
-
 <dl class="py method">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">static</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">_param_string</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">args</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">tuple</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">kwargs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">dict</span></span></em><span class="sig-paren">)</span></dt>
@@ -207,10 +201,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">functions</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">functions</span></span></dt>
+        <dd><p>list of functions to perform</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -229,10 +225,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">params</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">params</span></span></dt>
+        <dd><p>list of function parameters</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -279,12 +277,6 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">_is_paired_end</span></span></dt>
-<dd><p>indicates whether it is single-end or paired-end Pipeline</p>
-</dd></dl>
-
 <dl class="py method">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">static</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">_param_string</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">args</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">tuple</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">kwargs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">dict</span></span></em><span class="sig-paren">)</span></dt>
@@ -340,10 +332,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">functions</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">functions</span></span></dt>
+        <dd><p>list of functions to perform</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -362,10 +356,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">params</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">params</span></span></dt>
+        <dd><p>list of function parameters</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -388,8 +384,10 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dd></dl>
 
 <dl class="py class">
-<dt class="sig sig-object py">
-<em class="property"><span class="pre">class</span><span class="w"> </span></em><span class="sig-prename descclassname"><span class="pre">rnalysis.fastq.</span></span><span class="sig-name descname"><span class="pre">_FASTQPipeline</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">is_paired_end</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span></dt>
+    <dt class="sig sig-object py">
+        <em class="property"><span class="pre">class</span><span class="w"> </span></em><span
+        class="sig-prename descclassname"><span class="pre">rnalysis.fastq.</span></span><span
+        class="sig-name descname"><span class="pre">_FASTQPipeline</span></span></dt>
 <dd><p>Bases: <code class="xref py py-class docutils literal notranslate"><span class="pre">GenericPipeline</span></code>, <code class="xref py py-class docutils literal notranslate"><span class="pre">ABC</span></code></p>
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -412,12 +410,6 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">_is_paired_end</span></span></dt>
-<dd><p>indicates whether it is single-end or paired-end Pipeline</p>
-</dd></dl>
-
 <dl class="py method">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">static</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">_param_string</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">args</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">tuple</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">kwargs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">dict</span></span></em><span class="sig-paren">)</span></dt>
@@ -473,10 +465,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">functions</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">functions</span></span></dt>
+        <dd><p>list of functions to perform</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -495,10 +489,12 @@ <h2>rnalysis.fastq module<a class="headerlink" href="#rnalysis-fastq-module" tit
 </dl>
 </dd></dl>
 
-<dl class="py attribute">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">params</span></span></dt>
-<dd></dd></dl>
+    <dl class="py attribute">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">params</span></span></dt>
+        <dd><p>list of function parameters</p>
+        </dd>
+    </dl>
 
 <dl class="py method">
 <dt class="sig sig-object py">
@@ -941,8 +937,34 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<em class="property"><span class="pre">static</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">_pca_plot</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">final_df</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">DataFrame</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pc1_var</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pc2_var</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">sample_grouping</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">GroupedColumns</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
+    <dt class="sig sig-object py">
+        <em class="property"><span class="pre">static</span><span class="w"> </span></em><span
+        class="sig-name descname"><span class="pre">_pca_plot</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">final_df</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">DataFrame</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pc1_var</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">pc2_var</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">sample_grouping</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">GroupedColumns</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">float</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">float</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">proportional_axes</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">plot_grid</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span></em><span
+        class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span
+        class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
 <dd><p>Internal method, used to plot the results from CountFilter.pca().</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -2277,8 +2299,58 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_grid</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span
+        class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Performs Principal Component Analysis (PCA), visualizing the principal components that explain the most        variance between the different samples. The function will standardize the data prior to PCA, and then plot         the requested number of pairwise PCA projections.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -2292,6 +2364,8 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 <li><p><strong>label_fontsize</strong> (<em>float</em><em> (</em><em>default=15</em><em>)</em>) – determines the font size of the X and Y axis labels.</p></li>
 <li><p><strong>tick_fontsize</strong> (<em>float</em><em> (</em><em>default=10</em><em>)</em>) – determines the font size of the X and Y tick labels, and the sample name labels. .</p></li>
 <li><p><strong>proportional_axes</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the dimensions of the PCA plots will be proportional         to the percentage of variance explained by each principal component.</p></li>
+    <li><p><strong>plot_grid</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will draw a
+        grid on the PCA plot.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Returns</dt>
@@ -2367,25 +2441,181 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Saves the current filtered data to a .csv file.</p>
-<dl class="field-list simple">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
-</dd>
-</dl>
-</dd></dl>
-
-<dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">scatter_sample_vs_sample</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">sample1</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">sample2</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">xlabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">annotation_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Sequence</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">point_color</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Color</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'#6d7178'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight_color</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Color</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'#00aaff'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">opacity</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.65</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">point_size</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">interactive</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_cursor</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
-<dd><p>Generate a scatter plot where every dot is a feature, the x value is log10 of reads         (counts, RPM, RPKM, TPM, etc) in sample1, the y value is log10 of reads in sample2.         If the plot is generated in interactive mode, data points can be labeled by clicking on them.</p>
-<dl class="field-list simple">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>sample1</strong> (<em>string</em><em> or </em><em>list</em><em> of </em><em>strings</em>) – Name of the first sample from the CountFilter object.         If sample1 is a list, they will be avarged as replicates.</p></li>
-<li><p><strong>sample2</strong> (<em>string</em><em> or </em><em>list</em><em> of </em><em>strings</em>) – Name of the second sample from the CountFilter object.         If sample2 is a list, they will be averaged as replicates.</p></li>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span
+        class="sig-paren">)</span></dt>
+    <dd><p>Saves the current filtered data to a .csv file.</p>
+        <dl class="field-list simple">
+            <dt class="field-odd">Parameters</dt>
+            <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                automatically according to the filtering methods used. If it’s a string, it will be used as the name of
+                the saved file. Example input: ‘myfilename’</p>
+            </dd>
+        </dl>
+    </dd>
+</dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Saves the current filtered data to a .parquet file.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                    or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                    automatically according to the filtering methods used. If it’s a string, it will be used as the name
+                    of the saved file. Example input: ‘myfilename’</p>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_table</span></span><span
+            class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span
+            class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="s"><span
+            class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Save the current filtered data table.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em>
+                            (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+                        <li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em>
+                            (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically
+                            according to the filtering methods used. If it’s a string, it will be used as the name of
+                            the saved file. Example input: ‘myfilename’</p></li>
+                    </ul>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">scatter_sample_vs_sample</span></span><span
+            class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">sample1</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>,
+            <em class="sig-param"><span class="n"><span class="pre">sample2</span></span><span class="p"><span
+                class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>,
+            <em class="sig-param"><span class="n"><span class="pre">xlabel</span></span><span class="p"><span
+                class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+                class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+                class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+                class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+                class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+                class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+                class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+            class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+            class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">title_fontsize</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">float</span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">annotation_fontsize</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">float</span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Sequence</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">point_color</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Color</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'#6d7178'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight_color</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Color</span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'#00aaff'</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">opacity</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">0.65</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">point_size</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">interactive</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">show_cursor</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span
+            class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Figure</span></span></span></dt>
+        <dd><p>Generate a scatter plot where every dot is a feature, the x value is log10 of reads (counts, RPM, RPKM,
+            TPM, etc) in sample1, the y value is log10 of reads in sample2. If the plot is generated in interactive
+            mode, data points can be labeled by clicking on them.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>sample1</strong> (<em>string</em><em> or </em><em>list</em><em> of </em><em>strings</em>)
+                            – Name of the first sample from the CountFilter object. If sample1 is a list, they will be
+                            avarged as replicates.</p></li>
+                        <li><p><strong>sample2</strong> (<em>string</em><em> or </em><em>list</em><em> of </em><em>strings</em>)
+                            – Name of the second sample from the CountFilter object. If sample2 is a list, they will be
+                            averaged as replicates.</p></li>
 <li><p><strong>xlabel</strong> (<em>str</em><em> or </em><em>'auto'</em>) – optional. If not specified, sample1 will be used as xlabel.</p></li>
 <li><p><strong>ylabel</strong> (<em>str</em><em> or </em><em>'auto'</em>) – optional. If not specified, sample2 will be used as ylabel.</p></li>
 <li><p><strong>title</strong> (<em>str</em><em> or </em><em>'auto'</em>) – optional. If not specified, a title will be generated automatically.</p></li>
@@ -4070,25 +4300,124 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Saves the current filtered data to a .csv file.</p>
-<dl class="field-list simple">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
-</dd>
-</dl>
-</dd></dl>
-
-<dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Sort the rows by the values of specified column or columns.</p>
-<dl class="field-list">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) – Names of the column or columns to sort by.</p></li>
-<li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em> of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending. Specify list for multiple sort orders.         If this is a list of bools, it must have the same length as ‘by’.</p></li>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span
+        class="sig-paren">)</span></dt>
+    <dd><p>Saves the current filtered data to a .csv file.</p>
+        <dl class="field-list simple">
+            <dt class="field-odd">Parameters</dt>
+            <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                automatically according to the filtering methods used. If it’s a string, it will be used as the name of
+                the saved file. Example input: ‘myfilename’</p>
+            </dd>
+        </dl>
+    </dd>
+</dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Saves the current filtered data to a .parquet file.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                    or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                    automatically according to the filtering methods used. If it’s a string, it will be used as the name
+                    of the saved file. Example input: ‘myfilename’</p>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_table</span></span><span
+            class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span
+            class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="s"><span
+            class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Save the current filtered data table.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em>
+                            (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+                        <li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em>
+                            (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically
+                            according to the filtering methods used. If it’s a string, it will be used as the name of
+                            the saved file. Example input: ‘myfilename’</p></li>
+                    </ul>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em
+            class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Sort the rows by the values of specified column or columns.</p>
+            <dl class="field-list">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) –
+                            Names of the column or columns to sort by.</p></li>
+                        <li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em>
+                            of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending.
+                            Specify list for multiple sort orders. If this is a list of bools, it must have the same
+                            length as ‘by’.</p></li>
 <li><p><strong>na_position</strong> (<em>'first'</em><em> or </em><em>'last'</em><em>, </em><em>default 'last'</em>) – If ‘first’, puts NaNs at the beginning; if ‘last’, puts NaNs at the end.</p></li>
 <li><p><strong>inplace</strong> (<em>bool</em><em>, </em><em>default True</em>) – If True, perform operation in-place.         Otherwise, returns a sorted copy of the Filter object without modifying the original.</p></li>
 </ul>
@@ -5292,26 +5621,125 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dl>
 </dd></dl>
 
-<dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Saves the current filtered data to a .csv file.</p>
-<dl class="field-list simple">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
-</dd>
-</dl>
-</dd></dl>
-
-<dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Sort the rows by the values of specified column or columns.</p>
-<dl class="field-list">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) – Names of the column or columns to sort by.</p></li>
-<li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em> of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending. Specify list for multiple sort orders.         If this is a list of bools, it must have the same length as ‘by’.</p></li>
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Saves the current filtered data to a .csv file.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                    or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                    automatically according to the filtering methods used. If it’s a string, it will be used as the name
+                    of the saved file. Example input: ‘myfilename’</p>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Saves the current filtered data to a .parquet file.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                    or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                    automatically according to the filtering methods used. If it’s a string, it will be used as the name
+                    of the saved file. Example input: ‘myfilename’</p>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_table</span></span><span
+            class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span
+            class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="s"><span
+            class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Save the current filtered data table.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em>
+                            (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+                        <li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em>
+                            (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically
+                            according to the filtering methods used. If it’s a string, it will be used as the name of
+                            the saved file. Example input: ‘myfilename’</p></li>
+                    </ul>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em
+            class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Sort the rows by the values of specified column or columns.</p>
+            <dl class="field-list">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) –
+                            Names of the column or columns to sort by.</p></li>
+                        <li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em>
+                            of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending.
+                            Specify list for multiple sort orders. If this is a list of bools, it must have the same
+                            length as ‘by’.</p></li>
 <li><p><strong>na_position</strong> (<em>'first'</em><em> or </em><em>'last'</em><em>, </em><em>default 'last'</em>) – If ‘first’, puts NaNs at the beginning; if ‘last’, puts NaNs at the end.</p></li>
 <li><p><strong>inplace</strong> (<em>bool</em><em>, </em><em>default True</em>) – If True, perform operation in-place.         Otherwise, returns a sorted copy of the Filter object without modifying the original.</p></li>
 </ul>
@@ -6554,25 +6982,124 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Saves the current filtered data to a .csv file.</p>
-<dl class="field-list simple">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
-</dd>
-</dl>
-</dd></dl>
-
-<dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Sort the rows by the values of specified column or columns.</p>
-<dl class="field-list">
-<dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) – Names of the column or columns to sort by.</p></li>
-<li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em> of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending. Specify list for multiple sort orders.         If this is a list of bools, it must have the same length as ‘by’.</p></li>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">save_csv</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span
+        class="sig-paren">)</span></dt>
+    <dd><p>Saves the current filtered data to a .csv file.</p>
+        <dl class="field-list simple">
+            <dt class="field-odd">Parameters</dt>
+            <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                automatically according to the filtering methods used. If it’s a string, it will be used as the name of
+                the saved file. Example input: ‘myfilename’</p>
+            </dd>
+        </dl>
+    </dd>
+</dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Saves the current filtered data to a .parquet file.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>,
+                    or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated
+                    automatically according to the filtering methods used. If it’s a string, it will be used as the name
+                    of the saved file. Example input: ‘myfilename’</p>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">save_table</span></span><span
+            class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span
+            class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span
+            class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="s"><span
+            class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span
+            class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">Union</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Save the current filtered data table.</p>
+            <dl class="field-list simple">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em>
+                            (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+                        <li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em>
+                            (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically
+                            according to the filtering methods used. If it’s a string, it will be used as the name of
+                            the saved file. Example input: ‘myfilename’</p></li>
+                    </ul>
+                </dd>
+            </dl>
+        </dd>
+    </dl>
+
+    <dl class="py method">
+        <dt class="sig sig-object py">
+            <span class="sig-name descname"><span class="pre">sort</span></span><span class="sig-paren">(</span><em
+            class="sig-param"><span class="n"><span class="pre">by</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em
+            class="sig-param"><span class="n"><span class="pre">ascending</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">bool</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">na_position</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'last'</span></span></em>, <em class="sig-param"><span class="n"><span
+            class="pre">inplace</span></span><span class="p"><span class="pre">:</span></span><span
+            class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+            class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">True</span></span></em><span class="sig-paren">)</span></dt>
+        <dd><p>Sort the rows by the values of specified column or columns.</p>
+            <dl class="field-list">
+                <dt class="field-odd">Parameters</dt>
+                <dd class="field-odd">
+                    <ul class="simple">
+                        <li><p><strong>by</strong> (<em>str</em><em> or </em><em>list</em><em> of </em><em>str</em>) –
+                            Names of the column or columns to sort by.</p></li>
+                        <li><p><strong>ascending</strong> (<em>bool</em><em> or </em><em>list</em><em>
+                            of </em><em>bool</em><em>, </em><em>default True</em>) – Sort ascending vs. descending.
+                            Specify list for multiple sort orders. If this is a list of bools, it must have the same
+                            length as ‘by’.</p></li>
 <li><p><strong>na_position</strong> (<em>'first'</em><em> or </em><em>'last'</em><em>, </em><em>default 'last'</em>) – If ‘first’, puts NaNs at the beginning; if ‘last’, puts NaNs at the end.</p></li>
 <li><p><strong>inplace</strong> (<em>bool</em><em>, </em><em>default True</em>) – If True, perform operation in-place.         Otherwise, returns a sorted copy of the Filter object without modifying the original.</p></li>
 </ul>
@@ -7007,7 +7534,7 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 <dl class="py method">
 <dt class="sig sig-object py">
 <span class="sig-name descname"><span class="pre">add_function</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">func</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">function</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="o"><span class="pre">*</span></span><span class="n"><span class="pre">args</span></span></em>, <em class="sig-param"><span class="o"><span class="pre">**</span></span><span class="n"><span class="pre">kwargs</span></span></em><span class="sig-paren">)</span></dt>
-<dd><p>Add a function to the pipeline. Arguments can be stated with or without the correspoding keywords.         For example: Pipeline.add_function(‘sort’, ‘columnName’, ascending=False, na_position=’first’).         Pipelines support virtually all functions in the filtering module, including         filtering functions, normalization functions, splitting functions and plotting functions.         Do not include the ‘inplace’ argument when adding functions to a pipeline; instead,         include it when applying the pipeline to a Filter object using Pipeline.apply_to(). 
+<dd><p>Add a function to the pipeline. Arguments can be stated with or without the correspoding keywords.         For example: Pipeline.add_function(‘sort’, ‘columnName’, ascending=False, na_position=’first’).         Pipelines support virtually all functions in the filtering module, including         filtering functions, normalization functions, splitting functions and plotting functions.         Do not include the ‘inplace’ argument when adding functions to a pipeline; instead,         include it when applying the pipeline to a Filter object using Pipeline.apply_to().
 :param func: function to be added
 :type func: function or name of function from the filtering module
 :param args: unkeyworded arguments for the added function in their natural order. For example: 0.1, True
@@ -7349,8 +7876,386 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span
+        class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span
+        class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span
+        class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span
+        class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                             title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                              href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+                                                              title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Gene Ontology (GO) terms against a background set.         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -7385,24 +8290,39 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 :type return_nonsignificant: bool (default=False)
 :type save_csv: bool, default False
 :param save_csv: If True, will save the results to a .csv file, under the name specified in ‘fname’.
-:type fname: str or pathlib.Path
-:param fname: The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.
-:type return_fig: bool (default=False)
-:param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
-:type plot_ontology_graph: bool (default=True)
-:param plot_ontology_graph: if True, will generate an ontology graph depicting the         significant GO terms and their parent nodes.
-:type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or ‘none’ (default=’none’)
-:param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
-:type plot_horizontal: bool (default=True)
-:param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
-:type random_seed: non-negative integer (default=None)
-:type random_seed: if using a randomization test, determine the random seed used to initialize         the pseudorandom generator for the randomization test.         By default it is picked at random, but you can set it to a particular integer to get consistents results         over multiple runs. If not using a randomization test, this parameter will not affect the analysis.
-:param randomization_reps: if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.
-:type randomization_reps: int larger than 0 (default=10000)
-:type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
-:param parallel_backend: Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.
-:rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
-:return: a pandas DataFrame with GO terms as rows/index;         and a matplotlib Figure, if ‘return_figure’ is set to True.</p>
+    :type fname: str or pathlib.Path
+    :param fname: The full path and name of the file to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’
+    suffix is required. If None (default), fname will be requested in a manual prompt.
+    :type return_fig: bool (default=False)
+    :param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
+    :type plot_ontology_graph: bool (default=True)
+    :param plot_ontology_graph: if True, will generate an ontology graph depicting the significant GO terms and their
+    parent nodes.
+    :type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or ‘none’ (default=’none’)
+    :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be
+    generated in the specified file format.
+    :type plot_horizontal: bool (default=True)
+    :param plot_horizontal: if True, results will be plotted with a horizontal bar plot. Otherwise, results will be
+    plotted with a vertical plot.
+    :param show_expected: if True, the observed/expected values will be shown on the plot.
+    :type show_expected: bool (default=False)
+    :param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot in which the
+    lollipop size indicates the size of the observed gene set.
+    :type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
+    :type random_seed: non-negative integer (default=None)
+    :type random_seed: if using a randomization test, determine the random seed used to initialize the pseudorandom
+    generator for the randomization test. By default it is picked at random, but you can set it to a particular integer
+    to get consistents results over multiple runs. If not using a randomization test, this parameter will not affect the
+    analysis.
+    :param randomization_reps: if using a randomization test, determine how many randomization repititions to run.
+    Otherwise, this parameter will not affect the analysis.
+    :type randomization_reps: int larger than 0 (default=10000)
+    :type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
+    :param parallel_backend: Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’,
+    will calculate the statistical tests using parallel processing. In most cases parallel processing will lead to
+    shorter computation time, but does not affect the results of the analysis otherwise.
+    :rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
+    :return: a pandas DataFrame with GO terms as rows/index; and a matplotlib Figure, if ‘return_figure’ is set to True.</p>
 <figure class="align-center" id="id44">
 <a class="reference internal image-reference" href="_images/ontology_graph.png"><img alt="_images/ontology_graph.png" src="_images/ontology_graph.png" style="width: 840.0px; height: 540.0px;" /></a>
 <figcaption>
@@ -7477,8 +8397,264 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span 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class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span 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class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span
+        class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span
+        class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span
+        class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                             title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                              href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+                                                              title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways against a background set.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -7486,20 +8662,54 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>organism</strong> (<em>str</em><em> or </em><em>int</em>) – organism name or NCBI taxon ID for which the function will fetch GO annotations.</p></li>
 <li><p><strong>gene_id_type</strong> (<em>str</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – the identifier type of the genes/features in the FeatureSet object         (for example: ‘UniProtKB’, ‘WormBase’, ‘RNACentral’, ‘Entrez Gene ID’).         If the annotations fetched from the KEGG server do not match your gene_id_type, RNAlysis will attempt to map         the annotations’ gene IDs to your identifier type.         For a full list of legal ‘gene_id_type’ names, see the UniProt website:         <a class="reference external" href="https://www.uniprot.org/help/api_idmapping">https://www.uniprot.org/help/api_idmapping</a></p></li>
 <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – Indicates the FDR threshold for significance.</p></li>
-<li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em> (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.         Note that some propagation methods support only some of the available statistical tests.</p></li>
-<li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings each specifying a biotype</em><em>, or </em><em>'all'.         Default 'protein_coding'.</em>) – determines the background genes by their biotype. Requires specifying a Biotype Reference Table.         ‘all’ will include all genomic features in the reference table,         ‘protein_coding’ will include only protein-coding genes from the reference table, etc.         Cannot be specified together with ‘background_genes’.</p></li>
-<li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter object</em><em>, or </em><em>enrichment.FeatureSet object</em>) – a set of specific feature indices to be used as background genes.         Cannot be specified together with ‘biotype’.</p></li>
-<li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Biotype Reference Table.         Will be used to generate background set if ‘biotype’ is specified.</p></li>
-<li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.</p></li>
-<li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the results DataFrame will include all tested pathways -         both significant and non-significant ones. If False (default), only significant pathways will be returned.</p></li>
-<li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the results to a .csv file, under the name specified in ‘fname’.</p></li>
-<li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
-<li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
-<li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
-<li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
-<li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
-<li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
+    <li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em>
+        (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.
+        Note that some propagation methods support only some of the available statistical tests.</p></li>
+    <li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings
+        each specifying a biotype</em><em>, or </em><em>'all'. Default 'protein_coding'.</em>) – determines the
+        background genes by their biotype. Requires specifying a Biotype Reference Table. ‘all’ will include all genomic
+        features in the reference table, ‘protein_coding’ will include only protein-coding genes from the reference
+        table, etc. Cannot be specified together with ‘background_genes’.</p></li>
+    <li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter
+        object</em><em>, or </em><em>enrichment.FeatureSet object</em>) – a set of specific feature indices to be used
+        as background genes. Cannot be specified together with ‘biotype’.</p></li>
+    <li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Biotype Reference Table. Will be used to generate background set if ‘biotype’ is specified.
+    </p></li>
+    <li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if
+        True, genes that have no annotation associated with them will be excluded from the enrichment analysis. This is
+        the recommended practice for enrichment analysis, since keeping unannotated genes in the analysis increases the
+        chance of discovering spurious enrichment results.</p></li>
+    <li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True,
+        the results DataFrame will include all tested pathways - both significant and non-significant ones. If False
+        (default), only significant pathways will be returned.</p></li>
+    <li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the results
+        to a .csv file, under the name specified in ‘fname’.</p></li>
+    <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file
+        to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname
+        will be requested in a manual prompt.</p></li>
+    <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a
+        matplotlib Figure object in addition to the results DataFrame.</p></li>
+    <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results
+        will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.</p></li>
+    <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+        observed/expected values will be shown on the plot.</p></li>
+    <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+        (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a
+        lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+    <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+        will generate pathway graphs depicting the significant KEGG pathways.</p></li>
+    <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>,
+        or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the
+        pathway graphs will additonally be generated in the specified file format.</p></li>
+    <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) –
+        if using a randomization test, determine how many randomization repititions to run. Otherwise, this parameter
+        will not affect the analysis.</p></li>
+    <li><p><strong>parallel_backend</strong>
+        (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) –
+        Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’, will calculate the
+        statistical tests using parallel processing. In most cases parallel processing will lead to shorter computation
+        time, but does not affect the results of the analysis otherwise.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Return type</dt>
@@ -7687,8 +8897,129 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+            class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                                              href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                                                                              title="rnalysis.filtering.Filter"><span
+        class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a
+        class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+        title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for user-defined attributes against a background set.        The attributes are drawn from an Attribute Reference Table.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -7696,18 +9027,50 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>attributes</strong> (<em>str</em><em>, </em><em>int</em><em>, </em><em>iterable</em><em> (</em><em>list</em><em>, </em><em>tuple</em><em>, </em><em>set</em><em>, </em><em>etc</em><em>) of </em><em>str/int</em><em>, or </em><em>'all'.</em>) – An iterable of attribute names or attribute numbers         (according to their order in the Attribute Reference Table).         If ‘all’, all of the attributes in the Attribute Reference Table will be used.         If None, a manual input prompt will be raised.</p></li>
 <li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em> (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.         Note that some propagation methods support only some of the available statistical tests.</p></li>
 <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – Indicates the FDR threshold for significance.</p></li>
-<li><p><strong>attr_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Attribute Reference Table from which user-defined attributes will be drawn.</p></li>
-<li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Biotype Reference Table.         Will be used to generate background set if ‘biotype’ is specified.</p></li>
-<li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings each specifying a biotype</em><em>, or </em><em>'all'</em><em>         (</em><em>default='protein_coding'</em><em>)</em>) – determines the background genes by their biotype. Requires specifying a Biotype Reference Table.         ‘all’ will include all genomic features in the reference table,         ‘protein_coding’ will include only protein-coding genes from the reference table, etc.         Cannot be specified together with ‘background_genes’.</p></li>
-<li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter object</em><em>, or </em><em>enrichment.FeatureSet object</em><em>         (</em><em>default=None</em><em>)</em>) – a set of specific feature indices to be used as background genes.         Cannot be specified together with ‘biotype’.</p></li>
-<li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.</p></li>
-<li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True (default), the results DataFrame will include all tested attributes -         both significant and non-significant ones. If False, only significant attributes will be returned.</p></li>
-<li><p><strong>save_csv</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – If True, will save the results to a .csv file, under the name specified in ‘fname’.</p></li>
-<li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
-<li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot. Otherwise, results         will be plotted with a vertical plot.</p></li>
-<li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
-<li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
+    <li><p><strong>attr_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Attribute Reference Table from which user-defined attributes will be drawn.</p></li>
+    <li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Biotype Reference Table. Will be used to generate background set if ‘biotype’ is specified.
+    </p></li>
+    <li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings
+        each specifying a biotype</em><em>, or </em><em>'all'</em><em> (</em><em>default='protein_coding'</em><em>)</em>)
+        – determines the background genes by their biotype. Requires specifying a Biotype Reference Table. ‘all’ will
+        include all genomic features in the reference table, ‘protein_coding’ will include only protein-coding genes
+        from the reference table, etc. Cannot be specified together with ‘background_genes’.</p></li>
+    <li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter
+        object</em><em>, or </em><em>enrichment.FeatureSet object</em><em> (</em><em>default=None</em><em>)</em>) – a
+        set of specific feature indices to be used as background genes. Cannot be specified together with ‘biotype’.</p>
+    </li>
+    <li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if
+        True, genes that have no annotation associated with them will be excluded from the enrichment analysis. This is
+        the recommended practice for enrichment analysis, since keeping unannotated genes in the analysis increases the
+        chance of discovering spurious enrichment results.</p></li>
+    <li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True
+        (default), the results DataFrame will include all tested attributes - both significant and non-significant ones.
+        If False, only significant attributes will be returned.</p></li>
+    <li><p><strong>save_csv</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – If True, will save the
+        results to a .csv file, under the name specified in ‘fname’.</p></li>
+    <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em>
+        (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For
+        example: ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual
+        prompt.</p></li>
+    <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a
+        matplotlib Figure object in addition to the results DataFrame.</p></li>
+    <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results
+        will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.</p></li>
+    <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+        observed/expected values will be shown on the plot.</p></li>
+    <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+        (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a
+        lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+    <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) –
+        if using a randomization test, determine how many randomization repititions to run. Otherwise, this parameter
+        will not affect the analysis.</p></li>
+    <li><p><strong>parallel_backend</strong>
+        (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) –
+        Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’, will calculate the
+        statistical tests using parallel processing. In most cases parallel processing will lead to shorter computation
+        time, but does not affect the results of the analysis otherwise.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Return type</dt>
@@ -7939,8 +9302,386 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <dd></dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span
+        class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span
+        class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span
+        class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span
+        class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                             title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                              href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+                                                              title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Gene Ontology (GO) terms against a background set.         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -7975,24 +9716,39 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 :type return_nonsignificant: bool (default=False)
 :type save_csv: bool, default False
 :param save_csv: If True, will save the results to a .csv file, under the name specified in ‘fname’.
-:type fname: str or pathlib.Path
-:param fname: The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.
-:type return_fig: bool (default=False)
-:param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
-:type plot_ontology_graph: bool (default=True)
-:param plot_ontology_graph: if True, will generate an ontology graph depicting the         significant GO terms and their parent nodes.
-:type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or ‘none’ (default=’none’)
-:param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
-:type plot_horizontal: bool (default=True)
-:param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
-:type random_seed: non-negative integer (default=None)
-:type random_seed: if using a randomization test, determine the random seed used to initialize         the pseudorandom generator for the randomization test.         By default it is picked at random, but you can set it to a particular integer to get consistents results         over multiple runs. If not using a randomization test, this parameter will not affect the analysis.
-:param randomization_reps: if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.
-:type randomization_reps: int larger than 0 (default=10000)
-:type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
-:param parallel_backend: Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.
-:rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
-:return: a pandas DataFrame with GO terms as rows/index;         and a matplotlib Figure, if ‘return_figure’ is set to True.</p>
+    :type fname: str or pathlib.Path
+    :param fname: The full path and name of the file to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’
+    suffix is required. If None (default), fname will be requested in a manual prompt.
+    :type return_fig: bool (default=False)
+    :param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
+    :type plot_ontology_graph: bool (default=True)
+    :param plot_ontology_graph: if True, will generate an ontology graph depicting the significant GO terms and their
+    parent nodes.
+    :type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or ‘none’ (default=’none’)
+    :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be
+    generated in the specified file format.
+    :type plot_horizontal: bool (default=True)
+    :param plot_horizontal: if True, results will be plotted with a horizontal bar plot. Otherwise, results will be
+    plotted with a vertical plot.
+    :param show_expected: if True, the observed/expected values will be shown on the plot.
+    :type show_expected: bool (default=False)
+    :param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot in which the
+    lollipop size indicates the size of the observed gene set.
+    :type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
+    :type random_seed: non-negative integer (default=None)
+    :type random_seed: if using a randomization test, determine the random seed used to initialize the pseudorandom
+    generator for the randomization test. By default it is picked at random, but you can set it to a particular integer
+    to get consistents results over multiple runs. If not using a randomization test, this parameter will not affect the
+    analysis.
+    :param randomization_reps: if using a randomization test, determine how many randomization repititions to run.
+    Otherwise, this parameter will not affect the analysis.
+    :type randomization_reps: int larger than 0 (default=10000)
+    :type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
+    :param parallel_backend: Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’,
+    will calculate the statistical tests using parallel processing. In most cases parallel processing will lead to
+    shorter computation time, but does not affect the results of the analysis otherwise.
+    :rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
+    :return: a pandas DataFrame with GO terms as rows/index; and a matplotlib Figure, if ‘return_figure’ is set to True.</p>
 <figure class="align-center" id="id53">
 <a class="reference internal image-reference" href="_images/ontology_graph.png"><img alt="_images/ontology_graph.png" src="_images/ontology_graph.png" style="width: 840.0px; height: 540.0px;" /></a>
 <figcaption>
@@ -8067,8 +9823,264 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span
+        class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span
+        class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span
+        class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                             title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                              href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+                                                              title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways against a background set.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -8076,20 +10088,54 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>organism</strong> (<em>str</em><em> or </em><em>int</em>) – organism name or NCBI taxon ID for which the function will fetch GO annotations.</p></li>
 <li><p><strong>gene_id_type</strong> (<em>str</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – the identifier type of the genes/features in the FeatureSet object         (for example: ‘UniProtKB’, ‘WormBase’, ‘RNACentral’, ‘Entrez Gene ID’).         If the annotations fetched from the KEGG server do not match your gene_id_type, RNAlysis will attempt to map         the annotations’ gene IDs to your identifier type.         For a full list of legal ‘gene_id_type’ names, see the UniProt website:         <a class="reference external" href="https://www.uniprot.org/help/api_idmapping">https://www.uniprot.org/help/api_idmapping</a></p></li>
 <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – Indicates the FDR threshold for significance.</p></li>
-<li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em> (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.         Note that some propagation methods support only some of the available statistical tests.</p></li>
-<li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings each specifying a biotype</em><em>, or </em><em>'all'.         Default 'protein_coding'.</em>) – determines the background genes by their biotype. Requires specifying a Biotype Reference Table.         ‘all’ will include all genomic features in the reference table,         ‘protein_coding’ will include only protein-coding genes from the reference table, etc.         Cannot be specified together with ‘background_genes’.</p></li>
-<li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter object</em><em>, or </em><em>enrichment.FeatureSet object</em>) – a set of specific feature indices to be used as background genes.         Cannot be specified together with ‘biotype’.</p></li>
-<li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Biotype Reference Table.         Will be used to generate background set if ‘biotype’ is specified.</p></li>
-<li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.</p></li>
-<li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the results DataFrame will include all tested pathways -         both significant and non-significant ones. If False (default), only significant pathways will be returned.</p></li>
-<li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the results to a .csv file, under the name specified in ‘fname’.</p></li>
-<li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
-<li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
-<li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
-<li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
-<li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
-<li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
+    <li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em>
+        (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.
+        Note that some propagation methods support only some of the available statistical tests.</p></li>
+    <li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings
+        each specifying a biotype</em><em>, or </em><em>'all'. Default 'protein_coding'.</em>) – determines the
+        background genes by their biotype. Requires specifying a Biotype Reference Table. ‘all’ will include all genomic
+        features in the reference table, ‘protein_coding’ will include only protein-coding genes from the reference
+        table, etc. Cannot be specified together with ‘background_genes’.</p></li>
+    <li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter
+        object</em><em>, or </em><em>enrichment.FeatureSet object</em>) – a set of specific feature indices to be used
+        as background genes. Cannot be specified together with ‘biotype’.</p></li>
+    <li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Biotype Reference Table. Will be used to generate background set if ‘biotype’ is specified.
+    </p></li>
+    <li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if
+        True, genes that have no annotation associated with them will be excluded from the enrichment analysis. This is
+        the recommended practice for enrichment analysis, since keeping unannotated genes in the analysis increases the
+        chance of discovering spurious enrichment results.</p></li>
+    <li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True,
+        the results DataFrame will include all tested pathways - both significant and non-significant ones. If False
+        (default), only significant pathways will be returned.</p></li>
+    <li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the results
+        to a .csv file, under the name specified in ‘fname’.</p></li>
+    <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file
+        to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname
+        will be requested in a manual prompt.</p></li>
+    <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a
+        matplotlib Figure object in addition to the results DataFrame.</p></li>
+    <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results
+        will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.</p></li>
+    <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+        observed/expected values will be shown on the plot.</p></li>
+    <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+        (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a
+        lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+    <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+        will generate pathway graphs depicting the significant KEGG pathways.</p></li>
+    <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>,
+        or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the
+        pathway graphs will additonally be generated in the specified file format.</p></li>
+    <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) –
+        if using a randomization test, determine how many randomization repititions to run. Otherwise, this parameter
+        will not affect the analysis.</p></li>
+    <li><p><strong>parallel_backend</strong>
+        (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) –
+        Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’, will calculate the
+        statistical tests using parallel processing. In most cases parallel processing will lead to shorter computation
+        time, but does not affect the results of the analysis otherwise.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Return type</dt>
@@ -8193,8 +10239,76 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <dd></dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for user-defined attributes         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The attributes are drawn from an Attribute Reference Table.         P-values are calculated using using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -8233,8 +10347,337 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span
+        class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span
+        class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span
+        class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span
+        class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span
+        class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Gene Ontology (GO) terms         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -8261,24 +10704,37 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 :type excluded_qualifiers: str, Iterable of str, or None (default=’not’)
 :param exclude_unannotated_genes: if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.
 :type exclude_unannotated_genes: bool (deafult=True)
-:param return_nonsignificant: if True, the results DataFrame will include all tested GO terms -         both significant and non-significant terms. If False (default),         only significant GO terms will be returned.
-:type return_nonsignificant: bool (default=False)
-:type save_csv: bool, default False
-:param save_csv: If True, will save the results to a .csv file, under the name specified in ‘fname’.
-:type fname: str or pathlib.Path
-:param fname: The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default),         fname will be requested in a manual prompt.
-:type return_fig: bool (default=False)
-:param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
-:type plot_horizontal: bool (default=True)
-:param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
-:type plot_ontology_graph: bool (default=True)
-:param plot_ontology_graph: if True, will generate an ontology graph depicting the         significant GO terms and their parent nodes.
-:type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or None (default=None)
-:param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
-:type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
-:param parallel_backend: Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.
-:rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
-:return: a pandas DataFrame with the indicated attribute names as rows/index;         and a matplotlib Figure, if ‘return_figure’ is set to True.</p>
+    :param return_nonsignificant: if True, the results DataFrame will include all tested GO terms - both significant and
+    non-significant terms. If False (default), only significant GO terms will be returned.
+    :type return_nonsignificant: bool (default=False)
+    :type save_csv: bool, default False
+    :param save_csv: If True, will save the results to a .csv file, under the name specified in ‘fname’.
+    :type fname: str or pathlib.Path
+    :param fname: The full path and name of the file to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’
+    suffix is required. If None (default), fname will be requested in a manual prompt.
+    :type return_fig: bool (default=False)
+    :param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
+    :type plot_horizontal: bool (default=True)
+    :param plot_horizontal: if True, results will be plotted with a horizontal bar plot. Otherwise, results will be
+    plotted with a vertical plot.
+    :param show_expected: if True, the observed/expected values will be shown on the plot.
+    :type show_expected: bool (default=False)
+    :param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot in which the
+    lollipop size indicates the size of the observed gene set.
+    :type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
+    :type plot_ontology_graph: bool (default=True)
+    :param plot_ontology_graph: if True, will generate an ontology graph depicting the significant GO terms and their
+    parent nodes.
+    :type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or None (default=None)
+    :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be
+    generated in the specified file format.
+    :type parallel_backend: Literal[PARALLEL_BACKENDS] (default=’loky’)
+    :param parallel_backend: Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’,
+    will calculate the statistical tests using parallel processing. In most cases parallel processing will lead to
+    shorter computation time, but does not affect the results of the analysis otherwise.
+    :rtype: pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]
+    :return: a pandas DataFrame with the indicated attribute names as rows/index; and a matplotlib Figure, if
+    ‘return_figure’ is set to True.</p>
 <figure class="align-center" id="id62">
 <a class="reference internal image-reference" href="_images/ontology_graph_singlelist.png"><img alt="_images/ontology_graph_singlelist.png" src="_images/ontology_graph_singlelist.png" style="width: 840.0px; height: 540.0px;" /></a>
 <figcaption>
@@ -8300,25 +10756,265 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span
+        class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span
+        class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span
+        class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span
+        class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span
+        class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span
+        class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span
+        class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span
+        class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span
+        class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span
+        class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span
+        class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em
+        class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span
+        class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways WITHOUT a background set, using the generalized Minimum Hypergeometric Test         (XL-mHG, developed by <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>organism</strong> (<em>str</em><em> or </em><em>int</em>) – organism name or NCBI taxon ID for which the function will fetch GO annotations.</p></li>
-<li><p><strong>gene_id_type</strong> (<em>str</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – the identifier type of the genes/features in the FeatureSet object         (for example: ‘UniProtKB’, ‘WormBase’, ‘RNACentral’, ‘Entrez Gene ID’).         If the annotations fetched from the KEGG server do not match your gene_id_type,         RNAlysis will attempt to map  the annotations’ gene IDs to your identifier type.         For a full list of legal ‘gene_id_type’ names, see the UniProt website:         <a class="reference external" href="https://www.uniprot.org/help/api_idmapping">https://www.uniprot.org/help/api_idmapping</a></p></li>
-<li><p><strong>alpha</strong> (<em>float between 0 and 1</em>) – Indicates the FDR threshold for significance.</p></li>
-<li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.</p></li>
-<li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the results DataFrame will include all tested GO terms -         both significant and non-significant terms. If False (default),         only significant KEGG pathways will be returned.</p></li>
-<li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the results to a .csv file, under the name specified in ‘fname’.</p></li>
-<li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default),         fname will be requested in a manual prompt.</p></li>
-<li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
-<li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
-<li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
-<li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
-</ul>
+<dd class="field-odd">
+    <ul class="simple">
+        <li><p><strong>organism</strong> (<em>str</em><em> or </em><em>int</em>) – organism name or NCBI taxon ID for
+            which the function will fetch GO annotations.</p></li>
+        <li><p><strong>gene_id_type</strong> (<em>str</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>)
+            – the identifier type of the genes/features in the FeatureSet object (for example: ‘UniProtKB’, ‘WormBase’,
+            ‘RNACentral’, ‘Entrez Gene ID’). If the annotations fetched from the KEGG server do not match your
+            gene_id_type, RNAlysis will attempt to map the annotations’ gene IDs to your identifier type. For a full
+            list of legal ‘gene_id_type’ names, see the UniProt website: <a class="reference external"
+                                                                            href="https://www.uniprot.org/help/api_idmapping">https://www.uniprot.org/help/api_idmapping</a>
+        </p></li>
+        <li><p><strong>alpha</strong> (<em>float between 0 and 1</em>) – Indicates the FDR threshold for significance.
+        </p></li>
+        <li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if
+            True, genes that have no annotation associated with them will be excluded from the enrichment analysis. This
+            is the recommended practice for enrichment analysis, since keeping unannotated genes in the analysis
+            increases the chance of discovering spurious enrichment results.</p></li>
+        <li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if
+            True, the results DataFrame will include all tested GO terms - both significant and non-significant terms.
+            If False (default), only significant KEGG pathways will be returned.</p></li>
+        <li><p><strong>save_csv</strong> (<em>bool</em><em>, </em><em>default False</em>) – If True, will save the
+            results to a .csv file, under the name specified in ‘fname’.</p></li>
+        <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the
+            file to which to save the results. For example: ‘C:/dir/file’. No ‘.csv’ suffix is required. If None
+            (default), fname will be requested in a manual prompt.</p></li>
+        <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns
+            a matplotlib Figure object in addition to the results DataFrame.</p></li>
+        <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+            results will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.
+        </p></li>
+        <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+            observed/expected values will be shown on the plot.</p></li>
+        <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+            (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for
+            a lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+        <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+            will generate pathway graphs depicting the significant KEGG pathways.</p></li>
+        <li><p><strong>pathway_graphs_format</strong>
+            (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>)
+            – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be generated in the specified
+            file format.</p></li>
+        <li><p><strong>parallel_backend</strong>
+            (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>)
+            – Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’, will calculate the
+            statistical tests using parallel processing. In most cases parallel processing will lead to shorter
+            computation time, but does not affect the results of the analysis otherwise.</p></li>
+    </ul>
 </dd>
 <dt class="field-even">Return type</dt>
 <dd class="field-even"><p>pd.DataFrame (default) or Tuple[pd.DataFrame, matplotlib.figure.Figure]</p>
@@ -8437,8 +11133,129 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py method">
-<dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span
+        class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span
+            class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span
+            class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span
+            class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+            class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+            class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+            class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal"
+                                                                              href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"
+                                                                              title="rnalysis.filtering.Filter"><span
+        class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a
+        class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet"
+        title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span
+        class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span
+        class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span
+        class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span
+        class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span
+            class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+            class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span>
+    </dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for user-defined attributes against a background set.        The attributes are drawn from an Attribute Reference Table.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -8446,18 +11263,50 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>attributes</strong> (<em>str</em><em>, </em><em>int</em><em>, </em><em>iterable</em><em> (</em><em>list</em><em>, </em><em>tuple</em><em>, </em><em>set</em><em>, </em><em>etc</em><em>) of </em><em>str/int</em><em>, or </em><em>'all'.</em>) – An iterable of attribute names or attribute numbers         (according to their order in the Attribute Reference Table).         If ‘all’, all of the attributes in the Attribute Reference Table will be used.         If None, a manual input prompt will be raised.</p></li>
 <li><p><strong>statistical_test</strong> (<em>'fisher'</em><em>, </em><em>'hypergeometric'</em><em> or </em><em>'randomization'</em><em> (</em><em>default='fisher'</em><em>)</em>) – determines the statistical test to be used for enrichment analysis.         Note that some propagation methods support only some of the available statistical tests.</p></li>
 <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – Indicates the FDR threshold for significance.</p></li>
-<li><p><strong>attr_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Attribute Reference Table from which user-defined attributes will be drawn.</p></li>
-<li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>) – the path of the Biotype Reference Table.         Will be used to generate background set if ‘biotype’ is specified.</p></li>
-<li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings each specifying a biotype</em><em>, or </em><em>'all'</em><em>         (</em><em>default='protein_coding'</em><em>)</em>) – determines the background genes by their biotype. Requires specifying a Biotype Reference Table.         ‘all’ will include all genomic features in the reference table,         ‘protein_coding’ will include only protein-coding genes from the reference table, etc.         Cannot be specified together with ‘background_genes’.</p></li>
-<li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter object</em><em>, or </em><em>enrichment.FeatureSet object</em><em>         (</em><em>default=None</em><em>)</em>) – a set of specific feature indices to be used as background genes.         Cannot be specified together with ‘biotype’.</p></li>
-<li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if True, genes that have no annotation associated with them will be         excluded from the enrichment analysis. This is the recommended practice for enrichment analysis, since         keeping unannotated genes in the analysis increases the chance of discovering spurious enrichment results.</p></li>
-<li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True (default), the results DataFrame will include all tested attributes -         both significant and non-significant ones. If False, only significant attributes will be returned.</p></li>
-<li><p><strong>save_csv</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – If True, will save the results to a .csv file, under the name specified in ‘fname’.</p></li>
-<li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
-<li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot. Otherwise, results         will be plotted with a vertical plot.</p></li>
-<li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
-<li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
+    <li><p><strong>attr_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Attribute Reference Table from which user-defined attributes will be drawn.</p></li>
+    <li><p><strong>biotype_ref_path</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default='predefined'</em><em>)</em>)
+        – the path of the Biotype Reference Table. Will be used to generate background set if ‘biotype’ is specified.
+    </p></li>
+    <li><p><strong>biotype</strong> (<em>str specifying a specific biotype</em><em>, </em><em>list/set</em><em> of </em><em>strings
+        each specifying a biotype</em><em>, or </em><em>'all'</em><em> (</em><em>default='protein_coding'</em><em>)</em>)
+        – determines the background genes by their biotype. Requires specifying a Biotype Reference Table. ‘all’ will
+        include all genomic features in the reference table, ‘protein_coding’ will include only protein-coding genes
+        from the reference table, etc. Cannot be specified together with ‘background_genes’.</p></li>
+    <li><p><strong>background_genes</strong> (<em>set</em><em> of </em><em>feature indices</em><em>, </em><em>filtering.Filter
+        object</em><em>, or </em><em>enrichment.FeatureSet object</em><em> (</em><em>default=None</em><em>)</em>) – a
+        set of specific feature indices to be used as background genes. Cannot be specified together with ‘biotype’.</p>
+    </li>
+    <li><p><strong>exclude_unannotated_genes</strong> (<em>bool</em><em> (</em><em>deafult=True</em><em>)</em>) – if
+        True, genes that have no annotation associated with them will be excluded from the enrichment analysis. This is
+        the recommended practice for enrichment analysis, since keeping unannotated genes in the analysis increases the
+        chance of discovering spurious enrichment results.</p></li>
+    <li><p><strong>return_nonsignificant</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True
+        (default), the results DataFrame will include all tested attributes - both significant and non-significant ones.
+        If False, only significant attributes will be returned.</p></li>
+    <li><p><strong>save_csv</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – If True, will save the
+        results to a .csv file, under the name specified in ‘fname’.</p></li>
+    <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em>
+        (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For
+        example: ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual
+        prompt.</p></li>
+    <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a
+        matplotlib Figure object in addition to the results DataFrame.</p></li>
+    <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results
+        will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.</p></li>
+    <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+        observed/expected values will be shown on the plot.</p></li>
+    <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+        (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a
+        lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+    <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) –
+        if using a randomization test, determine how many randomization repititions to run. Otherwise, this parameter
+        will not affect the analysis.</p></li>
+    <li><p><strong>parallel_backend</strong>
+        (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) –
+        Determines the babckend used to run the analysis. if parallel_backend not ‘sequential’, will calculate the
+        statistical tests using parallel processing. In most cases parallel processing will lead to shorter computation
+        time, but does not affect the results of the analysis otherwise.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Return type</dt>
@@ -8501,22 +11350,109 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 </dd></dl>
 
 <dl class="py function">
-<dt class="sig sig-object py">
-<span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
+    <dt class="sig sig-object py">
+        <span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span
+        class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+        class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span
+        class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span
+        class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span
+        class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span
+        class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+            class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Figure</span></span></span></dt>
 <dd><p>Generate an enrichment bar-plot based on an enrichment results table.     For the clarity of display, complete depletion (linear enrichment = 0)     appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>results_table_path</strong> (<em>str</em><em> or </em><em>Path</em>) – Path to the results table returned by enrichment functions.</p></li>
-<li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – the threshold for statistical significance. Used to draw significance asterisks on the graph.</p></li>
-<li><p><strong>enrichment_score_column</strong> (<em>str</em><em> (</em><em>default='log2_fold_enrichment'</em><em>)</em>) – name of the table column containing enrichment scores.</p></li>
-<li><p><strong>n_bars</strong> (<em>int &gt; 1</em><em> or </em><em>'all'</em><em> (</em><em>default='all'</em><em>)</em>) – number of bars to display in the bar plot. If n_bars=’all’,      all the results will be displayed on the graph. Otherwise, only the top n results will be displayed on the graph.</p></li>
-<li><p><strong>title</strong> (<em>str</em>) – plot title.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
-<li><p><strong>ylabel</strong> (<em>str</em><em> (</em><em>default=r&quot;$log_2$</em><em>(</em><em>Fold Enrichment</em><em>)</em><em>&quot;</em><em>)</em>) – plot y-axis label.</p></li>
-<li><p><strong>center_bars</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, center the bars around Y=0. Otherwise, ylim is determined by min/max values.</p></li>
-<li><p><strong>ylim</strong> (<em>float</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – set the Y-axis limits. If <cite>ylim`=’auto’, determines the axis limits automatically based on the data.     If `ylim</cite> is a number, set the Y-axis limits to [-ylim, ylim].</p></li>
-</ul>
+<dd class="field-odd">
+    <ul class="simple">
+        <li><p><strong>results_table_path</strong> (<em>str</em><em> or </em><em>Path</em>) – Path to the results table
+            returned by enrichment functions.</p></li>
+        <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – the
+            threshold for statistical significance. Used to draw significance asterisks on the graph.</p></li>
+        <li><p><strong>enrichment_score_column</strong> (<em>str</em><em>
+            (</em><em>default='log2_fold_enrichment'</em><em>)</em>) – name of the table column containing enrichment
+            scores.</p></li>
+        <li><p><strong>n_bars</strong> (<em>int &gt; 1</em><em> or </em><em>'all'</em><em>
+            (</em><em>default='all'</em><em>)</em>) – number of bars to display in the bar plot. If n_bars=’all’, all
+            the results will be displayed on the graph. Otherwise, only the top n results will be displayed on the
+            graph.</p></li>
+        <li><p><strong>title</strong> (<em>str</em>) – plot title.</p></li>
+        <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+            results will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.
+        </p></li>
+        <li><p><strong>ylabel</strong> (<em>str</em><em> (</em><em>default=r&quot;$log_2$</em><em>(</em><em>Fold
+            Enrichment</em><em>)</em><em>&quot;</em><em>)</em>) – plot y-axis label.</p></li>
+        <li><p><strong>center_bars</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, center
+            the bars around Y=0. Otherwise, ylim is determined by min/max values.</p></li>
+        <li><p><strong>ylim</strong> (<em>float</em><em> or </em><em>'auto'</em><em>
+            (</em><em>default='auto'</em><em>)</em>) – set the Y-axis limits. If <cite>ylim`=’auto’, determines the axis
+            limits automatically based on the data. If `ylim</cite> is a number, set the Y-axis limits to [-ylim, ylim].
+        </p></li>
+        <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+            (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for
+            a lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+        <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+            observed/expected values will be shown on the plot.</p></li>
+    </ul>
 </dd>
 <dt class="field-even">Returns</dt>
 <dd class="field-even"><p>Figure object containing the bar plot</p>
@@ -8791,7 +11727,7 @@ <h2>rnalysis.utils module<a class="headerlink" href="#rnalysis-utils-module" tit
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-   
+
 
 </footer>
         </div>
@@ -8802,7 +11738,7 @@ <h2>rnalysis.utils module<a class="headerlink" href="#rnalysis-utils-module" tit
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script> 
+  </script>
 
 </body>
-</html>
\ No newline at end of file
+</html>
diff --git a/docs/build/contributing.html b/docs/build/contributing.html
index 8641d87a..68ce184d 100644
--- a/docs/build/contributing.html
+++ b/docs/build/contributing.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>How can I contribute to RNAlysis? &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>How can I contribute to RNAlysis? &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -12,31 +12,31 @@
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
 
-        <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
-        <script src="_static/jquery.js"></script>
-        <script src="_static/underscore.js"></script>
-        <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
-        <script src="_static/doctools.js"></script>
-        <script src="_static/sphinx_highlight.js"></script>
-        <script src="_static/copybutton.js"></script>
+    <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
+    <script src="_static/jquery.js"></script>
+    <script src="_static/underscore.js"></script>
+    <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
+    <script src="_static/doctools.js"></script>
+    <script src="_static/sphinx_highlight.js"></script>
+    <script src="_static/copybutton.js"></script>
     <script src="_static/js/theme.js"></script>
-    <link rel="index" title="Index" href="genindex.html" />
-    <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="Installation" href="installation.html" />
-    <link rel="prev" title="What is RNAlysis?" href="readme.html" />
+    <link rel="index" title="Index" href="genindex.html"/>
+    <link rel="search" title="Search" href="search.html"/>
+    <link rel="next" title="Installation" href="installation.html"/>
+    <link rel="prev" title="What is RNAlysis?" href="readme.html"/>
 </head>
 
 <body class="wy-body-for-nav">
-  <div class="wy-grid-for-nav">
+<div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
-      <div class="wy-side-scroll">
-        <div class="wy-side-nav-search" >
-            <a href="index.html">
-            <img src="_static/logo.png" class="logo" alt="Logo"/>
-          </a>
-<div role="search">
-  <form id="rtd-search-form" class="wy-form" action="search.html" method="get">
-    <input type="text" name="q" placeholder="Search docs" />
+        <div class="wy-side-scroll">
+            <div class="wy-side-nav-search">
+                <a href="index.html">
+                    <img src="_static/logo.png" class="logo" alt="Logo"/>
+                </a>
+                <div role="search">
+                    <form id="rtd-search-form" class="wy-form" action="search.html" method="get">
+                        <input type="text" name="q" placeholder="Search docs"/>
     <input type="hidden" name="check_keywords" value="yes" />
     <input type="hidden" name="area" value="default" />
   </form>
@@ -120,7 +120,7 @@
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
 
-  <section id="how-can-i-contribute-to-rnalysis">
+               <section id="how-can-i-contribute-to-rnalysis">
 <h1>How can I contribute to <em>RNAlysis</em>?<a class="headerlink" href="#how-can-i-contribute-to-rnalysis" title="Permalink to this heading"></a></h1>
 <p>Contributions are welcome, and they are greatly appreciated! Every little bit
 helps, and credit will always be given.</p>
@@ -288,16 +288,16 @@ <h2>Deploying<a class="headerlink" href="#deploying" title="Permalink to this he
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
 
 
-</footer>
+          </footer>
         </div>
       </div>
     </section>
-  </div>
-  <script>
-      jQuery(function () {
-          SphinxRtdTheme.Navigation.enable(true);
-      });
-  </script>
+</div>
+<script>
+    jQuery(function () {
+        SphinxRtdTheme.Navigation.enable(true);
+    });
+</script>
 
 </body>
 </html>
diff --git a/docs/build/faq.html b/docs/build/faq.html
index f02f8a77..65913971 100644
--- a/docs/build/faq.html
+++ b/docs/build/faq.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>Frequently asked questions &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>Frequently asked questions &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
diff --git a/docs/build/genindex.html b/docs/build/genindex.html
index deb311ac..febd7249 100644
--- a/docs/build/genindex.html
+++ b/docs/build/genindex.html
@@ -3,14 +3,14 @@
 <head>
   <meta charset="utf-8" />
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>Index &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>Index &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
   <!--[if lt IE 9]>
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
-  
+
         <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
         <script src="_static/jquery.js"></script>
         <script src="_static/underscore.js"></script>
@@ -20,10 +20,10 @@
         <script src="_static/copybutton.js"></script>
     <script src="_static/js/theme.js"></script>
     <link rel="index" title="Index" href="#" />
-    <link rel="search" title="Search" href="search.html" /> 
+    <link rel="search" title="Search" href="search.html" />
 </head>
 
-<body class="wy-body-for-nav"> 
+<body class="wy-body-for-nav">
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -99,7 +99,7 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-             
+
 
 <h1 id="index">Index</h1>
 
@@ -123,7 +123,7 @@ <h1 id="index">Index</h1>
  | <a href="#T"><strong>T</strong></a>
  | <a href="#U"><strong>U</strong></a>
  | <a href="#V"><strong>V</strong></a>
- 
+
 </div>
 <h2 id="_">_</h2>
 <table style="width: 100%" class="indextable genindextable"><tr>
@@ -820,25 +820,70 @@ <h2 id="R">R</h2>
 
 <h2 id="S">S</h2>
 <table style="width: 100%" class="indextable genindextable"><tr>
-  <td style="width: 33%; vertical-align: top;"><ul>
-      <li><a href="rnalysis.filtering.CountFilter.save_csv.html#rnalysis.filtering.CountFilter.save_csv">save_csv() (rnalysis.filtering.CountFilter method)</a>
-
-      <ul>
-        <li><a href="rnalysis.filtering.DESeqFilter.save_csv.html#rnalysis.filtering.DESeqFilter.save_csv">(rnalysis.filtering.DESeqFilter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.Filter.save_csv.html#rnalysis.filtering.Filter.save_csv">(rnalysis.filtering.Filter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.save_csv.html#rnalysis.filtering.FoldChangeFilter.save_csv">(rnalysis.filtering.FoldChangeFilter method)</a>
-</li>
-      </ul></li>
-      <li><a href="rnalysis.general.save_to_csv.html#rnalysis.general.save_to_csv">save_to_csv() (in module rnalysis.general)</a>
-</li>
-      <li><a href="rnalysis.enrichment.FeatureSet.save_txt.html#rnalysis.enrichment.FeatureSet.save_txt">save_txt() (rnalysis.enrichment.FeatureSet method)</a>
-
-      <ul>
-        <li><a href="rnalysis.enrichment.RankedSet.save_txt.html#rnalysis.enrichment.RankedSet.save_txt">(rnalysis.enrichment.RankedSet method)</a>
-</li>
-      </ul></li>
+  <td style="width: 33%; vertical-align: top;">
+      <ul>
+          <li><a href="rnalysis.filtering.CountFilter.save_csv.html#rnalysis.filtering.CountFilter.save_csv">save_csv()
+              (rnalysis.filtering.CountFilter method)</a>
+
+              <ul>
+                  <li><a href="rnalysis.filtering.DESeqFilter.save_csv.html#rnalysis.filtering.DESeqFilter.save_csv">(rnalysis.filtering.DESeqFilter
+                      method)</a>
+                  </li>
+                  <li><a href="rnalysis.filtering.Filter.save_csv.html#rnalysis.filtering.Filter.save_csv">(rnalysis.filtering.Filter
+                      method)</a>
+                  </li>
+                  <li><a
+                      href="rnalysis.filtering.FoldChangeFilter.save_csv.html#rnalysis.filtering.FoldChangeFilter.save_csv">(rnalysis.filtering.FoldChangeFilter
+                      method)</a>
+                  </li>
+              </ul>
+          </li>
+          <li><a href="rnalysis.filtering.CountFilter.save_parquet.html#rnalysis.filtering.CountFilter.save_parquet">save_parquet()
+              (rnalysis.filtering.CountFilter method)</a>
+
+              <ul>
+                  <li><a
+                      href="rnalysis.filtering.DESeqFilter.save_parquet.html#rnalysis.filtering.DESeqFilter.save_parquet">(rnalysis.filtering.DESeqFilter
+                      method)</a>
+                  </li>
+                  <li><a href="rnalysis.filtering.Filter.save_parquet.html#rnalysis.filtering.Filter.save_parquet">(rnalysis.filtering.Filter
+                      method)</a>
+                  </li>
+                  <li><a
+                      href="rnalysis.filtering.FoldChangeFilter.save_parquet.html#rnalysis.filtering.FoldChangeFilter.save_parquet">(rnalysis.filtering.FoldChangeFilter
+                      method)</a>
+                  </li>
+              </ul>
+          </li>
+          <li><a href="rnalysis.filtering.CountFilter.save_table.html#rnalysis.filtering.CountFilter.save_table">save_table()
+              (rnalysis.filtering.CountFilter method)</a>
+
+              <ul>
+                  <li><a
+                      href="rnalysis.filtering.DESeqFilter.save_table.html#rnalysis.filtering.DESeqFilter.save_table">(rnalysis.filtering.DESeqFilter
+                      method)</a>
+                  </li>
+                  <li><a href="rnalysis.filtering.Filter.save_table.html#rnalysis.filtering.Filter.save_table">(rnalysis.filtering.Filter
+                      method)</a>
+                  </li>
+                  <li><a
+                      href="rnalysis.filtering.FoldChangeFilter.save_table.html#rnalysis.filtering.FoldChangeFilter.save_table">(rnalysis.filtering.FoldChangeFilter
+                      method)</a>
+                  </li>
+              </ul>
+          </li>
+          <li><a href="rnalysis.general.save_to_csv.html#rnalysis.general.save_to_csv">save_to_csv() (in module
+              rnalysis.general)</a>
+          </li>
+          <li><a href="rnalysis.enrichment.FeatureSet.save_txt.html#rnalysis.enrichment.FeatureSet.save_txt">save_txt()
+              (rnalysis.enrichment.FeatureSet method)</a>
+
+              <ul>
+                  <li><a href="rnalysis.enrichment.RankedSet.save_txt.html#rnalysis.enrichment.RankedSet.save_txt">(rnalysis.enrichment.RankedSet
+                      method)</a>
+                  </li>
+              </ul>
+          </li>
       <li><a href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html#rnalysis.filtering.CountFilter.scatter_sample_vs_sample">scatter_sample_vs_sample() (rnalysis.filtering.CountFilter method)</a>
 </li>
       <li><a href="rnalysis.general.set_attr_ref_table_path.html#rnalysis.general.set_attr_ref_table_path">set_attr_ref_table_path() (in module rnalysis.general)</a>
@@ -855,79 +900,95 @@ <h2 id="S">S</h2>
 </li>
       <li><a href="rnalysis.fastq.SingleEndPipeline.html#rnalysis.fastq.SingleEndPipeline">SingleEndPipeline (class in rnalysis.fastq)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.sort.html#rnalysis.filtering.CountFilter.sort">sort() (rnalysis.filtering.CountFilter method)</a>
+          <li><a href="rnalysis.filtering.CountFilter.sort.html#rnalysis.filtering.CountFilter.sort">sort()
+              (rnalysis.filtering.CountFilter method)</a>
 
-      <ul>
-        <li><a href="rnalysis.filtering.DESeqFilter.sort.html#rnalysis.filtering.DESeqFilter.sort">(rnalysis.filtering.DESeqFilter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.Filter.sort.html#rnalysis.filtering.Filter.sort">(rnalysis.filtering.Filter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.sort.html#rnalysis.filtering.FoldChangeFilter.sort">(rnalysis.filtering.FoldChangeFilter method)</a>
-</li>
-      </ul></li>
-      <li><a href="rnalysis.filtering.CountFilter.split_by_attribute.html#rnalysis.filtering.CountFilter.split_by_attribute">split_by_attribute() (rnalysis.filtering.CountFilter method)</a>
+              <ul>
+                  <li><a href="rnalysis.filtering.DESeqFilter.sort.html#rnalysis.filtering.DESeqFilter.sort">(rnalysis.filtering.DESeqFilter
+                      method)</a>
+                  </li>
+                  <li><a href="rnalysis.filtering.Filter.sort.html#rnalysis.filtering.Filter.sort">(rnalysis.filtering.Filter
+                      method)</a>
+                  </li>
+                  <li><a href="rnalysis.filtering.FoldChangeFilter.sort.html#rnalysis.filtering.FoldChangeFilter.sort">(rnalysis.filtering.FoldChangeFilter
+                      method)</a>
+                  </li>
+              </ul>
+          </li>
+      </ul>
+  </td>
+    <td style="width: 33%; vertical-align: top;">
+        <ul>
+            <li><a
+                href="rnalysis.filtering.CountFilter.split_by_attribute.html#rnalysis.filtering.CountFilter.split_by_attribute">split_by_attribute()
+                (rnalysis.filtering.CountFilter method)</a>
 
-      <ul>
-        <li><a href="rnalysis.filtering.DESeqFilter.split_by_attribute.html#rnalysis.filtering.DESeqFilter.split_by_attribute">(rnalysis.filtering.DESeqFilter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.Filter.split_by_attribute.html#rnalysis.filtering.Filter.split_by_attribute">(rnalysis.filtering.Filter method)</a>
-</li>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html#rnalysis.filtering.FoldChangeFilter.split_by_attribute">(rnalysis.filtering.FoldChangeFilter method)</a>
-</li>
-      </ul></li>
-  </ul></td>
-  <td style="width: 33%; vertical-align: top;"><ul>
-      <li><a href="rnalysis.filtering.CountFilter.split_by_percentile.html#rnalysis.filtering.CountFilter.split_by_percentile">split_by_percentile() (rnalysis.filtering.CountFilter method)</a>
+                <ul>
+                    <li><a
+                        href="rnalysis.filtering.DESeqFilter.split_by_attribute.html#rnalysis.filtering.DESeqFilter.split_by_attribute">(rnalysis.filtering.DESeqFilter
+                        method)</a>
+                    </li>
+                    <li><a
+                        href="rnalysis.filtering.Filter.split_by_attribute.html#rnalysis.filtering.Filter.split_by_attribute">(rnalysis.filtering.Filter
+                        method)</a>
+                    </li>
+                    <li><a
+                        href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html#rnalysis.filtering.FoldChangeFilter.split_by_attribute">(rnalysis.filtering.FoldChangeFilter
+                        method)</a>
+                    </li>
+                </ul>
+            </li>
+            <li><a href="rnalysis.filtering.CountFilter.split_by_percentile.html#rnalysis.filtering.CountFilter.split_by_percentile">split_by_percentile() (rnalysis.filtering.CountFilter method)</a>
 
-      <ul>
-        <li><a href="rnalysis.filtering.DESeqFilter.split_by_percentile.html#rnalysis.filtering.DESeqFilter.split_by_percentile">(rnalysis.filtering.DESeqFilter method)</a>
+                <ul>
+                    <li><a href="rnalysis.filtering.DESeqFilter.split_by_percentile.html#rnalysis.filtering.DESeqFilter.split_by_percentile">(rnalysis.filtering.DESeqFilter method)</a>
 </li>
-        <li><a href="rnalysis.filtering.Filter.split_by_percentile.html#rnalysis.filtering.Filter.split_by_percentile">(rnalysis.filtering.Filter method)</a>
+                    <li><a href="rnalysis.filtering.Filter.split_by_percentile.html#rnalysis.filtering.Filter.split_by_percentile">(rnalysis.filtering.Filter method)</a>
 </li>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html#rnalysis.filtering.FoldChangeFilter.split_by_percentile">(rnalysis.filtering.FoldChangeFilter method)</a>
+                    <li><a href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html#rnalysis.filtering.FoldChangeFilter.split_by_percentile">(rnalysis.filtering.FoldChangeFilter method)</a>
 </li>
-      </ul></li>
-      <li><a href="rnalysis.filtering.CountFilter.split_by_principal_components.html#rnalysis.filtering.CountFilter.split_by_principal_components">split_by_principal_components() (rnalysis.filtering.CountFilter method)</a>
+                </ul></li>
+            <li><a href="rnalysis.filtering.CountFilter.split_by_principal_components.html#rnalysis.filtering.CountFilter.split_by_principal_components">split_by_principal_components() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.split_by_reads.html#rnalysis.filtering.CountFilter.split_by_reads">split_by_reads() (rnalysis.filtering.CountFilter method)</a>
+            <li><a href="rnalysis.filtering.CountFilter.split_by_reads.html#rnalysis.filtering.CountFilter.split_by_reads">split_by_reads() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.split_clicom.html#rnalysis.filtering.CountFilter.split_clicom">split_clicom() (rnalysis.filtering.CountFilter method)</a>
+            <li><a href="rnalysis.filtering.CountFilter.split_clicom.html#rnalysis.filtering.CountFilter.split_clicom">split_clicom() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.DESeqFilter.split_fold_change_direction.html#rnalysis.filtering.DESeqFilter.split_fold_change_direction">split_fold_change_direction() (rnalysis.filtering.DESeqFilter method)</a>
+            <li><a href="rnalysis.filtering.DESeqFilter.split_fold_change_direction.html#rnalysis.filtering.DESeqFilter.split_fold_change_direction">split_fold_change_direction() (rnalysis.filtering.DESeqFilter method)</a>
 
-      <ul>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html#rnalysis.filtering.FoldChangeFilter.split_fold_change_direction">(rnalysis.filtering.FoldChangeFilter method)</a>
+                <ul>
+                    <li><a href="rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html#rnalysis.filtering.FoldChangeFilter.split_fold_change_direction">(rnalysis.filtering.FoldChangeFilter method)</a>
 </li>
-      </ul></li>
-      <li><a href="rnalysis.filtering.CountFilter.split_hdbscan.html#rnalysis.filtering.CountFilter.split_hdbscan">split_hdbscan() (rnalysis.filtering.CountFilter method)</a>
+                </ul></li>
+            <li><a href="rnalysis.filtering.CountFilter.split_hdbscan.html#rnalysis.filtering.CountFilter.split_hdbscan">split_hdbscan() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.split_hierarchical.html#rnalysis.filtering.CountFilter.split_hierarchical">split_hierarchical() (rnalysis.filtering.CountFilter method)</a>
+            <li><a href="rnalysis.filtering.CountFilter.split_hierarchical.html#rnalysis.filtering.CountFilter.split_hierarchical">split_hierarchical() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.split_kmeans.html#rnalysis.filtering.CountFilter.split_kmeans">split_kmeans() (rnalysis.filtering.CountFilter method)</a>
+            <li><a href="rnalysis.filtering.CountFilter.split_kmeans.html#rnalysis.filtering.CountFilter.split_kmeans">split_kmeans() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.filtering.CountFilter.split_kmedoids.html#rnalysis.filtering.CountFilter.split_kmedoids">split_kmedoids() (rnalysis.filtering.CountFilter method)</a>
+            <li><a href="rnalysis.filtering.CountFilter.split_kmedoids.html#rnalysis.filtering.CountFilter.split_kmedoids">split_kmedoids() (rnalysis.filtering.CountFilter method)</a>
 </li>
-      <li><a href="rnalysis.enrichment.FeatureSet.symmetric_difference.html#rnalysis.enrichment.FeatureSet.symmetric_difference">symmetric_difference() (rnalysis.enrichment.FeatureSet method)</a>
+            <li><a href="rnalysis.enrichment.FeatureSet.symmetric_difference.html#rnalysis.enrichment.FeatureSet.symmetric_difference">symmetric_difference() (rnalysis.enrichment.FeatureSet method)</a>
 
-      <ul>
-        <li><a href="rnalysis.enrichment.RankedSet.symmetric_difference.html#rnalysis.enrichment.RankedSet.symmetric_difference">(rnalysis.enrichment.RankedSet method)</a>
+                <ul>
+                    <li><a href="rnalysis.enrichment.RankedSet.symmetric_difference.html#rnalysis.enrichment.RankedSet.symmetric_difference">(rnalysis.enrichment.RankedSet method)</a>
 </li>
-        <li><a href="rnalysis.filtering.CountFilter.symmetric_difference.html#rnalysis.filtering.CountFilter.symmetric_difference">(rnalysis.filtering.CountFilter method)</a>
+                    <li><a href="rnalysis.filtering.CountFilter.symmetric_difference.html#rnalysis.filtering.CountFilter.symmetric_difference">(rnalysis.filtering.CountFilter method)</a>
 </li>
-        <li><a href="rnalysis.filtering.DESeqFilter.symmetric_difference.html#rnalysis.filtering.DESeqFilter.symmetric_difference">(rnalysis.filtering.DESeqFilter method)</a>
+                    <li><a href="rnalysis.filtering.DESeqFilter.symmetric_difference.html#rnalysis.filtering.DESeqFilter.symmetric_difference">(rnalysis.filtering.DESeqFilter method)</a>
 </li>
-        <li><a href="rnalysis.filtering.Filter.symmetric_difference.html#rnalysis.filtering.Filter.symmetric_difference">(rnalysis.filtering.Filter method)</a>
+                    <li><a href="rnalysis.filtering.Filter.symmetric_difference.html#rnalysis.filtering.Filter.symmetric_difference">(rnalysis.filtering.Filter method)</a>
 </li>
-        <li><a href="rnalysis.filtering.FoldChangeFilter.symmetric_difference.html#rnalysis.filtering.FoldChangeFilter.symmetric_difference">(rnalysis.filtering.FoldChangeFilter method)</a>
+                    <li><a href="rnalysis.filtering.FoldChangeFilter.symmetric_difference.html#rnalysis.filtering.FoldChangeFilter.symmetric_difference">(rnalysis.filtering.FoldChangeFilter method)</a>
 </li>
-      </ul></li>
-      <li><a href="rnalysis.enrichment.FeatureSet.symmetric_difference_update.html#rnalysis.enrichment.FeatureSet.symmetric_difference_update">symmetric_difference_update() (rnalysis.enrichment.FeatureSet method)</a>
+                </ul></li>
+            <li><a href="rnalysis.enrichment.FeatureSet.symmetric_difference_update.html#rnalysis.enrichment.FeatureSet.symmetric_difference_update">symmetric_difference_update() (rnalysis.enrichment.FeatureSet method)</a>
 
-      <ul>
-        <li><a href="rnalysis.enrichment.RankedSet.symmetric_difference_update.html#rnalysis.enrichment.RankedSet.symmetric_difference_update">(rnalysis.enrichment.RankedSet method)</a>
+                <ul>
+                    <li><a href="rnalysis.enrichment.RankedSet.symmetric_difference_update.html#rnalysis.enrichment.RankedSet.symmetric_difference_update">(rnalysis.enrichment.RankedSet method)</a>
 </li>
-      </ul></li>
-  </ul></td>
+                </ul></li>
+        </ul></td>
 </tr></table>
 
 <h2 id="T">T</h2>
@@ -1051,7 +1112,7 @@ <h2 id="V">V</h2>
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-   
+
 
 </footer>
         </div>
@@ -1062,7 +1123,7 @@ <h2 id="V">V</h2>
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script> 
+  </script>
 
 </body>
-</html>
\ No newline at end of file
+</html>
diff --git a/docs/build/glossary.html b/docs/build/glossary.html
index 8779f682..b12f2c38 100644
--- a/docs/build/glossary.html
+++ b/docs/build/glossary.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>Glossary - programmatic interface &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>Glossary - programmatic interface &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -12,31 +12,31 @@
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
 
-        <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
-        <script src="_static/jquery.js"></script>
-        <script src="_static/underscore.js"></script>
-        <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
-        <script src="_static/doctools.js"></script>
-        <script src="_static/sphinx_highlight.js"></script>
-        <script src="_static/copybutton.js"></script>
+    <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
+    <script src="_static/jquery.js"></script>
+    <script src="_static/underscore.js"></script>
+    <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
+    <script src="_static/doctools.js"></script>
+    <script src="_static/sphinx_highlight.js"></script>
+    <script src="_static/copybutton.js"></script>
     <script src="_static/js/theme.js"></script>
-    <link rel="index" title="Index" href="genindex.html" />
-    <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="History" href="history.html" />
-    <link rel="prev" title="User guide - programmatic interface" href="user_guide.html" />
+    <link rel="index" title="Index" href="genindex.html"/>
+    <link rel="search" title="Search" href="search.html"/>
+    <link rel="next" title="History" href="history.html"/>
+    <link rel="prev" title="User guide - programmatic interface" href="user_guide.html"/>
 </head>
 
 <body class="wy-body-for-nav">
-  <div class="wy-grid-for-nav">
+<div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
-      <div class="wy-side-scroll">
-        <div class="wy-side-nav-search" >
-            <a href="index.html">
-            <img src="_static/logo.png" class="logo" alt="Logo"/>
-          </a>
-<div role="search">
-  <form id="rtd-search-form" class="wy-form" action="search.html" method="get">
-    <input type="text" name="q" placeholder="Search docs" />
+        <div class="wy-side-scroll">
+            <div class="wy-side-nav-search">
+                <a href="index.html">
+                    <img src="_static/logo.png" class="logo" alt="Logo"/>
+                </a>
+                <div role="search">
+                    <form id="rtd-search-form" class="wy-form" action="search.html" method="get">
+                        <input type="text" name="q" placeholder="Search docs"/>
     <input type="hidden" name="check_keywords" value="yes" />
     <input type="hidden" name="area" value="default" />
   </form>
@@ -104,7 +104,7 @@
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
 
-  <section id="glossary-programmatic-interface">
+               <section id="glossary-programmatic-interface">
 <span id="glossary"></span><h1>Glossary - programmatic interface<a class="headerlink" href="#glossary-programmatic-interface" title="Permalink to this heading"></a></h1>
 <dl class="glossary simple">
 <dt id="term-Attribute-Reference-Table">Attribute Reference Table<a class="headerlink" href="#term-Attribute-Reference-Table" title="Permalink to this term"></a></dt><dd><p>A <cite>csv</cite> table that contains user-defined information (‘attributes’, such as ‘genes expressed in intestine’, ‘epigenetic genes’ or ‘genes that have paralogs’)
@@ -171,16 +171,16 @@
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
 
 
-</footer>
+          </footer>
         </div>
       </div>
     </section>
-  </div>
-  <script>
-      jQuery(function () {
-          SphinxRtdTheme.Navigation.enable(true);
-      });
-  </script>
+</div>
+<script>
+    jQuery(function () {
+        SphinxRtdTheme.Navigation.enable(true);
+    });
+</script>
 
 </body>
 </html>
diff --git a/docs/build/history.html b/docs/build/history.html
index 921bd034..c4247f7f 100644
--- a/docs/build/history.html
+++ b/docs/build/history.html
@@ -4,14 +4,14 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>History &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>History &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
   <!--[if lt IE 9]>
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
-  
+
         <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
         <script src="_static/jquery.js"></script>
         <script src="_static/underscore.js"></script>
@@ -23,10 +23,10 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.fastq" href="rnalysis.fastq.html" />
-    <link rel="prev" title="Glossary - programmatic interface" href="glossary.html" /> 
+    <link rel="prev" title="Glossary - programmatic interface" href="glossary.html" />
 </head>
 
-<body class="wy-body-for-nav"> 
+<body class="wy-body-for-nav">
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -66,138 +66,169 @@
 <p class="caption" role="heading"><span class="caption-text">Change history:</span></p>
 <ul class="current">
 <li class="toctree-l1 current"><a class="current reference internal" href="#">History</a><ul>
-<li class="toctree-l2"><a class="reference internal" href="#id1">3.8.0 (2023-05-07)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#added">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#changed">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#fixed">Fixed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#new-contributors">New Contributors</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id3">3.7.0 (2023-04-07)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id4">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id5">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id6">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id7">3.6.2 (2023-03-25)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id8">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id9">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id10">3.6.1 (2023-03-22)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id11">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id12">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id13">3.6.0 (2023-03-07)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id14">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id15">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id16">Fixed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id18">New Contributors</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id19">3.5.2 (2023-02-23)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id20">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id21">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id22">3.5.1 (2023-02-22)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id23">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id24">3.5.0 (2023-02-08)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id25">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id26">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id27">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id28">3.4.2 (2023-02-01)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id29">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id30">3.4.0 (2023-02-01)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id31">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id32">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id33">Fixed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#removed">Removed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id36">New Contributors</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id37">3.3.0 (2022-12-02)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id38">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id39">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id40">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id41">3.2.2 (2022-11-25)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id42">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id43">3.2.1 (2022-11-25)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id44">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id45">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id46">3.2.0 (2022-11-23)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id47">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id48">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id49">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id50">3.1.0 (2022-10-16)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id51">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id52">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id53">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id54">3.0.1 (2022-10-12)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="#id55">3.0.0 (2022-10-10)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id56">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id57">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id58">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id59">2.1.1 (2022-07-05)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id60">Changed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id61">2.1.0 (2022-04-16)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id62">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id63">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id64">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id65">2.0.1 (2022-04-02)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id66">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id67">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id68">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id69">2.0.0 (2021-12-05)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id70">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id71">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id72">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id73">1.3.5 (2020-05-27)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id74">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id75">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id76">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id77">1.3.4 (2020-04-07)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id78">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id79">Fixed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id80">1.3.3 (2020-03-28)</a><ul>
-<li class="toctree-l3"><a class="reference internal" href="#id81">Added</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id82">Changed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id83">Fixed</a></li>
-<li class="toctree-l3"><a class="reference internal" href="#id84">Removed</a></li>
-</ul>
-</li>
-<li class="toctree-l2"><a class="reference internal" href="#id85">1.3.2 (2019-12-11)</a></li>
+    <li class="toctree-l2"><a class="reference internal" href="#id1">3.9.0 (2023-06-09)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#added">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#changed">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#fixed">Fixed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#new-contributors">New Contributors</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id3">3.8.0 (2023-05-07)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id4">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id5">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id6">Fixed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id8">New Contributors</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id9">3.7.0 (2023-04-07)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id10">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id11">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id12">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id13">3.6.2 (2023-03-25)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id14">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id15">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id16">3.6.1 (2023-03-22)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id17">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id18">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id19">3.6.0 (2023-03-07)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id20">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id21">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id22">Fixed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id24">New Contributors</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id25">3.5.2 (2023-02-23)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id26">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id27">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id28">3.5.1 (2023-02-22)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id29">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id30">3.5.0 (2023-02-08)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id31">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id32">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id33">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id34">3.4.2 (2023-02-01)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id35">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id36">3.4.0 (2023-02-01)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id37">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id38">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id39">Fixed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#removed">Removed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id42">New Contributors</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id43">3.3.0 (2022-12-02)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id44">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id45">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id46">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id47">3.2.2 (2022-11-25)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id48">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id49">3.2.1 (2022-11-25)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id50">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id51">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id52">3.2.0 (2022-11-23)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id53">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id54">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id55">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id56">3.1.0 (2022-10-16)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id57">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id58">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id59">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id60">3.0.1 (2022-10-12)</a></li>
+    <li class="toctree-l2"><a class="reference internal" href="#id61">3.0.0 (2022-10-10)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id62">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id63">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id64">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id65">2.1.1 (2022-07-05)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id66">Changed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id67">2.1.0 (2022-04-16)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id68">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id69">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id70">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id71">2.0.1 (2022-04-02)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id72">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id73">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id74">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id75">2.0.0 (2021-12-05)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id76">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id77">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id78">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id79">1.3.5 (2020-05-27)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id80">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id81">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id82">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id83">1.3.4 (2020-04-07)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id84">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id85">Fixed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id86">1.3.3 (2020-03-28)</a>
+        <ul>
+            <li class="toctree-l3"><a class="reference internal" href="#id87">Added</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id88">Changed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id89">Fixed</a></li>
+            <li class="toctree-l3"><a class="reference internal" href="#id90">Removed</a></li>
+        </ul>
+    </li>
+    <li class="toctree-l2"><a class="reference internal" href="#id91">1.3.2 (2019-12-11)</a></li>
 </ul>
 </li>
 </ul>
@@ -237,304 +268,558 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-             
-  <section id="history">
-<h1>History<a class="headerlink" href="#history" title="Permalink to this heading"></a></h1>
-<section id="id1">
-<h2>3.8.0 (2023-05-07)<a class="headerlink" href="#id1" title="Permalink to this heading"></a></h2>
-<p>Version 3.8.0 of <em>RNAlysis</em> comes with several exciting new features, including the ability to generate interactive analysis reports automatically.
-This feature allows users to create an interactive graph of all the datasets they loaded into RNAlysis, the functions applied, and the outputs generated during the analysis.
-You can read more about this feature in the <a class="reference external" href="https://guyteichman.github.io/RNAlysis/build/tutorial.html#create-analysis-report">Tutorial chapter</a> and the <a class="reference external" href="https://guyteichman.github.io/RNAlysis/build/user_guide_gui.html#rnalysis-interactive-analysis-reports">User Guide chapter</a>.</p>
-<p>The new release also includes Pipelines for FASTQ functions, the ability to export normalization scaling factors, and other changes to improve the software’s performance.
-RNAlysis now supports Python 3.11, and many functions should now run faster. The software’s graphic interface has also improved significantly, and users will now see a clearer error message when attempting to load unsupported file formats.
-Lastly, the release also fixes several bugs.</p>
-<p>Please note that, since Python 3.7 will be reaching end of life as of June 2023, new versions of <em>RNAlysis</em> will no longer support it.</p>
-<section id="added">
-<h3>Added<a class="headerlink" href="#added" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>You can now generate interactive analysis reports automatically using the RNAlysis graphical interface. Read more about this feature <a class="reference external" href="https://guyteichman.github.io/RNAlysis/build/user_guide_gui.html">here</a>.</p></li>
-<li><p>Added Pipelines for the FASTQ module (SingleEndPipeline and PairedEndPipeline), allowing you to apply a series of functions (adapter trimming, alignment, quantification, etc) to a batch of sequence/alignment files.</p></li>
-<li><p>Added new parameter ‘return_scaling_factors’ to normalization functions, that allows you to access the scaling factors calculated by RNAlysis.</p></li>
-<li><p>Added new parameter ‘gzip_output’ to CutAdapt adapter trimming (fastq.trim_adapters_single_end and fastq.trim_adapters_paired_end), allowing users to determine whether or not the output files will be gzipped.</p></li>
-</ul>
-</section>
-<section id="changed">
-<h3>Changed<a class="headerlink" href="#changed" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>RNAlysis now supports Python 3.11, and no longer supports Python 3.7.</p></li>
-<li><p>Many of the functions in RNAlysis should now run faster.</p></li>
-<li><p>The RNAlysis graphic interface should now boot up significantly faster.</p></li>
-<li><p>RNAlysis now shows an easier to understand error message when users attempt to load a table in an unsupported format (e.g. Excel files).</p></li>
-<li><p>CutAdapt adapter trimming (fastq.trim_adapters_single_end and fastq.trim_adapters_paired_end) now outputs non-gzipped files by default.</p></li>
-<li><p>Standardized all plotting functions in the filtering module to return a matplotlib Figure object, which can be further modified by users.</p></li>
-</ul>
-</section>
-<section id="fixed">
-<h3>Fixed<a class="headerlink" href="#fixed" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>RNAlysis failing to map gene IDs during GO enrichment analysis should no longer raise an error (thanks to <a class="reference external" href="https://github.com/clockgene">clockgene</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/16">#16</a>).</p></li>
-<li><p>Fixed bug where the Command History window would not display history of the current tab immediately after clearing the current session.</p></li>
-<li><p>Fixed bug where adapter trimming would fail to run when using CutAdapt version &gt;= 4.4.0.</p></li>
-<li><p>Fixed bug where ‘Filter rows with duplicate names/IDs’ (Filter.filter_duplicate_ids) would raise an error when applied to some tables.</p></li>
-</ul>
-</section>
-<section id="new-contributors">
-<h3>New Contributors<a class="headerlink" href="#new-contributors" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p><a class="reference external" href="https://github.com/clockgene">clockgene</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/16">#16</a></p></li>
-</ul>
-</section>
-</section>
-<section id="id3">
-<h2>3.7.0 (2023-04-07)<a class="headerlink" href="#id3" title="Permalink to this heading"></a></h2>
-<p>This version introduces small RNA read alignment using ShortStack, new filtering functions, a new optional parameter for Principal Component Analysis, improvements to the graphical interface, and bug fixes.</p>
-<section id="id4">
-<h3>Added<a class="headerlink" href="#id4" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added small RNA read alignment using ShortStack (fastq.shortstack_align_smallrna).</p></li>
-<li><p>Added new filtering function ‘Filter specific rows by name’ (Filter.filter_by_row_name).</p></li>
-<li><p>Added new filtering function ‘Filter rows with duplicate names/IDs’ (Filter.filter_duplicate_ids).</p></li>
-<li><p>Function parameters in pop-up windows in the graphical interface can now be imported and exported.</p></li>
-<li><p>Added new parameter to Principal Component Analysis (CountFilter.pca) ‘proportional_axes’, that allows you to make the PCA projection axes proportional to the percentage of variance each PC explains.</p></li>
-<li><p>Improved clarity of error messages in the graphical interface.</p></li>
-</ul>
-</section>
-<section id="id5">
-<h3>Changed<a class="headerlink" href="#id5" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Tables loaded into RNAlysis that use integer-indices will now be converted to use string-indices.</p></li>
-<li><p>Refactored CountFilter.from_folder into CountFilter.from_folder_htseqcount, and added a new CountFilter.from_folder method that accepts a folder of count files in any format.</p></li>
-<li><p>In the RNAlysis graphical interface, optional parameters that can be disabled will now display the hint “disable this parammeter?” instead of “disable input?”.</p></li>
-<li><p>Added optional parameter ‘ylim’ to ‘create enrichment bar-plot’ function (enrichment.enrichment_bar_plot), allowing users to determine the Y-axis limits of the bar plot.</p></li>
-<li><p>Updated function signatures of ‘Visualize gene ontology’ and ‘Visualize KEGG pathway’ (enrichment.gene_ontology_graph and enrichment.kegg_pathway_graph) to make more sense.</p></li>
-<li><p>Removed parameter ‘report_read_assignment_path’ from featureCounts feature counting (fastq.featurecounts_single_end and fastq.featurecounts_paired_end).</p></li>
-<li><p>The RNAlysis graphical interface should now load more quickly.</p></li>
-<li><p>Progress bars in the graphical interface should now reflect elapsed/remaining time for tasks more accurately.</p></li>
-</ul>
-</section>
-<section id="id6">
-<h3>Fixed<a class="headerlink" href="#id6" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug in the function ‘Split into Higly and Lowly expressed genes’ (Filter.split_by_reads) where the two resulting tables would be named incorrectly (highly-expressed genes would be labeled ‘belowXreads’ and vice-versa).</p></li>
-<li><p>Fixed bug where the ‘column’ parameter of some functions (‘Filter by percentile’, ‘Split by percentile’, ‘Filter with a number filter’, ‘Filter with a text filter’) would not automatically detect column names in the graphical interface.</p></li>
-<li><p>Fixed bug where the ‘numerator’ and ‘denominator’ parameters of of the function ‘Calculate fold change’ would not automatically detect column names in the graphical interface.</p></li>
-<li><p>Fixed bug where tables with integer-indices could not be visualized properly through the graphical interface.</p></li>
-<li><p>Fixed bug in the function ‘featureCounts single-end’ (fastq.featurecounts_single_end) where setting parameter ‘report_read_assignment’ to any value other than None would raise an error.</p></li>
-<li><p>Functions that take column name/names as input (transform, filter_missing_values, filter_percentile, split_percentile) can now be applied to fold change tables (FoldCangeFilter objects).</p></li>
-<li><p>Fixed bug where the description for the ‘n_bars’ parameter of the ‘create enrichment bar-plot’ function (enrichment.enrichment_bar_plot) would not display properly.</p></li>
-<li><p>‘Visualize gene ontology’ and ‘Visualize KEGG pathway’ (enrichment.gene_ontology_graph and enrichment.kegg_pathway_graph) now have proper parameter descriptions.</p></li>
-<li><p>Fixed bug where in-place intersection and difference in the filtering module would fail when using recent versions of pandas.</p></li>
+
+               <section id="history">
+                   <h1>History<a class="headerlink" href="#history" title="Permalink to this heading"></a></h1>
+                   <section id="id1">
+                       <h2>3.9.0 (2023-06-09)<a class="headerlink" href="#id1" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>Version 3.9.0 of RNALysis introduces several enhancements and fixes to improve your
+                           experience.
+                           The release includes additional enrichment plot styles, a new option for PCA plots,
+                           the ability to load and save data tables in Parquet format, and new actions in the Help menu
+                           for reporting issues and suggesting improvements.
+                           The update also improves the performance of various functions, ensures consistency in font
+                           and theme settings,
+                           and addresses multiple bug fixes, including issues with automatic session reports and
+                           visualization functions.</p>
+                       <section id="added">
+                           <h3>Added<a class="headerlink" href="#added" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added additional parameters to enrichment bar plots
+                                   (enrichment.enrichment_bar_plot), including a new plot style (‘lollipop’) and
+                                   observed/expected labels on the graph.</p></li>
+                               <li><p>Added a new parameter to Principal Component Analysis plots (CountFilter.pca)
+                                   ‘plot_grid’, which can enable or disable adding a grid to PCA plots.</p></li>
+                               <li><p>RNAlysis can now load and save data tables in Parquet format (.parquet)</p></li>
+                               <li><p>Added new actions to the Help menu, allowing users to report issues, suggest
+                                   issues, or open discussions.</p></li>
+                           </ul>
+                       </section>
+                       <section id="changed">
+                           <h3>Changed<a class="headerlink" href="#changed" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Functions in the FASTQ model are now added to automatic session reports.</p></li>
+                               <li><p>Many of the functions in RNAlysis should now run faster.</p></li>
+                               <li><p>Font type, size, and color for help tooltips should now match the global font
+                                   settings.</p></li>
+                               <li><p>True/False toggle switches now scale with font size.</p></li>
+                               <li><p>When loading data tables into RNAlysis, you will now see only supported file
+                                   formats by default.</p></li>
+                               <li><p>Clustering PCA plots are now plotted in proportion to the % variance explained by
+                                   each PC.</p></li>
+                               <li><p>The legend in clustering PCA plots is now draggable.</p></li>
+                           </ul>
+                       </section>
+                       <section id="fixed">
+                           <h3>Fixed<a class="headerlink" href="#fixed" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where data tables generated through the FASTQ model would not display
+                                   properly in automatic session reports.</p></li>
+                               <li><p>Fixed bug where graphs generated through the Visualize Gene Sets window would not
+                                   be added to automatic analysis report.</p></li>
+                               <li><p>When saving a file through the graphical interface, automatically-suggested
+                                   filenames no longer contain illegal characters.</p></li>
+                               <li><p>Improved clarity of error message when R installation folder is not found.</p>
+                               </li>
+                               <li><p>Fixed bug where some input parameter widgets in the RNAlysis graphical interface
+                                   would not display properly.</p></li>
+                               <li><p>RNAlysis now provides a clearer warning message when attempting to run HDBSCAN
+                                   clustering, if the hdbscan package is not installed.</p></li>
+                               <li><p>Label text in PCA plots and hierarchical clustergrams should no longer be cropped
+                                   outside of the visible region of the plot.</p></li>
+                               <li><p>Fixed bug where some visualization functions, such as pair-plot
+                                   (CountFilter.pairplot) would not display properly due to version mismatches between
+                                   pandas and seaborn.</p></li>
+                               <li><p>Improved clarity of error messages when external apps’ (kallisto, bowtie2, etc)
+                                   installation folders are not found.</p></li>
+                               <li><p>Fixed bug where running the RNAlysis graphical interface on a new computer would
+                                   sometimes raise an error (thanks to <a class="reference external"
+                                                                          href="https://github.com/NeuroRookie">NeuroRookie</a>
+                                   in <a class="reference external"
+                                         href="https://github.com/GuyTeichman/RNAlysis/issues/25">#25</a>).</p></li>
+                               <li><p>Fixed a bug where the ‘min_samples’ parameter in HDBSCAN clustering could not be
+                                   disabled.</p></li>
+                               <li><p>Fixed a bug where applying a function to a gene set with inplace=False would cause
+                                   the new gene set to be called ‘New Table’.</p></li>
+                               <li><p>Fixed a bug where RNAlysis would display the message “Pipeline saved
+                                   successfully”, even when the user cancels the save operation.</p></li>
+                           </ul>
+                       </section>
+                       <section id="new-contributors">
+                           <h3>New Contributors<a class="headerlink" href="#new-contributors"
+                                                  title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p><a class="reference external"
+                                         href="https://github.com/NeuroRookie">NeuroRookie</a> in <a
+                                   class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/25">#25</a>
+                               </p></li>
+                           </ul>
+                       </section>
+                   </section>
+                   <section id="id3">
+                       <h2>3.8.0 (2023-05-07)<a class="headerlink" href="#id3" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>Version 3.8.0 of <em>RNAlysis</em> comes with several exciting new features, including the
+                           ability to generate interactive analysis reports automatically.
+                           This feature allows users to create an interactive graph of all the datasets they loaded into
+                           RNAlysis, the functions applied, and the outputs generated during the analysis.
+                           You can read more about this feature in the <a class="reference external"
+                                                                          href="https://guyteichman.github.io/RNAlysis/build/tutorial.html#create-analysis-report">Tutorial
+                               chapter</a> and the <a class="reference external"
+                                                      href="https://guyteichman.github.io/RNAlysis/build/user_guide_gui.html#rnalysis-interactive-analysis-reports">User
+                               Guide chapter</a>.</p>
+                       <p>The new release also includes Pipelines for FASTQ functions, the ability to export
+                           normalization scaling factors, and other changes to improve the software’s performance.
+                           RNAlysis now supports Python 3.11, and many functions should now run faster. The software’s
+                           graphic interface has also improved significantly, and users will now see a clearer error
+                           message when attempting to load unsupported file formats.
+                           Lastly, the release also fixes several bugs.</p>
+                       <p>Please note that, since Python 3.7 will be reaching end of life as of June 2023, new versions
+                           of <em>RNAlysis</em> will no longer support it.</p>
+                       <section id="id4">
+                           <h3>Added<a class="headerlink" href="#id4" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>You can now generate interactive analysis reports automatically using the RNAlysis
+                                   graphical interface. Read more about this feature <a class="reference external"
+                                                                                        href="https://guyteichman.github.io/RNAlysis/build/user_guide_gui.html">here</a>.
+                               </p></li>
+                               <li><p>Added Pipelines for the FASTQ module (SingleEndPipeline and PairedEndPipeline),
+                                   allowing you to apply a series of functions (adapter trimming, alignment,
+                                   quantification, etc) to a batch of sequence/alignment files.</p></li>
+                               <li><p>Added new parameter ‘return_scaling_factors’ to normalization functions, that
+                                   allows you to access the scaling factors calculated by RNAlysis.</p></li>
+                               <li><p>Added new parameter ‘gzip_output’ to CutAdapt adapter trimming
+                                   (fastq.trim_adapters_single_end and fastq.trim_adapters_paired_end), allowing users
+                                   to determine whether or not the output files will be gzipped.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id5">
+                           <h3>Changed<a class="headerlink" href="#id5" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>RNAlysis now supports Python 3.11, and no longer supports Python 3.7.</p></li>
+                               <li><p>Many of the functions in RNAlysis should now run faster.</p></li>
+                               <li><p>The RNAlysis graphic interface should now boot up significantly faster.</p></li>
+                               <li><p>RNAlysis now shows an easier to understand error message when users attempt to
+                                   load a table in an unsupported format (e.g. Excel files).</p></li>
+                               <li><p>CutAdapt adapter trimming (fastq.trim_adapters_single_end and
+                                   fastq.trim_adapters_paired_end) now outputs non-gzipped files by default.</p></li>
+                               <li><p>Standardized all plotting functions in the filtering module to return a matplotlib
+                                   Figure object, which can be further modified by users.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id6">
+                           <h3>Fixed<a class="headerlink" href="#id6" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>RNAlysis failing to map gene IDs during GO enrichment analysis should no longer
+                                   raise an error (thanks to <a class="reference external"
+                                                                href="https://github.com/clockgene">clockgene</a> in <a
+                                       class="reference external"
+                                       href="https://github.com/GuyTeichman/RNAlysis/issues/16">#16</a>).</p></li>
+                               <li><p>Fixed bug where the Command History window would not display history of the
+                                   current tab immediately after clearing the current session.</p></li>
+                               <li><p>Fixed bug where adapter trimming would fail to run when using CutAdapt version
+                                   &gt;= 4.4.0.</p></li>
+                               <li><p>Fixed bug where ‘Filter rows with duplicate names/IDs’
+                                   (Filter.filter_duplicate_ids) would raise an error when applied to some tables.</p>
+                               </li>
+                           </ul>
+                       </section>
+                       <section id="id8">
+                           <h3>New Contributors<a class="headerlink" href="#id8" title="Permalink to this heading"></a>
+                           </h3>
+                           <ul class="simple">
+                               <li><p><a class="reference external" href="https://github.com/clockgene">clockgene</a> in
+                                   <a class="reference external"
+                                      href="https://github.com/GuyTeichman/RNAlysis/issues/16">#16</a></p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id9">
+                       <h2>3.7.0 (2023-04-07)<a class="headerlink" href="#id9" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces small RNA read alignment using ShortStack, new filtering functions, a
+                           new optional parameter for Principal Component Analysis, improvements to the graphical
+                           interface, and bug fixes.</p>
+                       <section id="id10">
+                           <h3>Added<a class="headerlink" href="#id10" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added small RNA read alignment using ShortStack
+                                   (fastq.shortstack_align_smallrna).</p></li>
+                               <li><p>Added new filtering function ‘Filter specific rows by name’
+                                   (Filter.filter_by_row_name).</p></li>
+                               <li><p>Added new filtering function ‘Filter rows with duplicate names/IDs’
+                                   (Filter.filter_duplicate_ids).</p></li>
+                               <li><p>Function parameters in pop-up windows in the graphical interface can now be
+                                   imported and exported.</p></li>
+                               <li><p>Added new parameter to Principal Component Analysis (CountFilter.pca)
+                                   ‘proportional_axes’, that allows you to make the PCA projection axes proportional to
+                                   the percentage of variance each PC explains.</p></li>
+                               <li><p>Improved clarity of error messages in the graphical interface.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id11">
+                           <h3>Changed<a class="headerlink" href="#id11" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Tables loaded into RNAlysis that use integer-indices will now be converted to use
+                                   string-indices.</p></li>
+                               <li><p>Refactored CountFilter.from_folder into CountFilter.from_folder_htseqcount, and
+                                   added a new CountFilter.from_folder method that accepts a folder of count files in
+                                   any format.</p></li>
+                               <li><p>In the RNAlysis graphical interface, optional parameters that can be disabled will
+                                   now display the hint “disable this parammeter?” instead of “disable input?”.</p></li>
+                               <li><p>Added optional parameter ‘ylim’ to ‘create enrichment bar-plot’ function
+                                   (enrichment.enrichment_bar_plot), allowing users to determine the Y-axis limits of
+                                   the bar plot.</p></li>
+                               <li><p>Updated function signatures of ‘Visualize gene ontology’ and ‘Visualize KEGG
+                                   pathway’ (enrichment.gene_ontology_graph and enrichment.kegg_pathway_graph) to make
+                                   more sense.</p></li>
+                               <li><p>Removed parameter ‘report_read_assignment_path’ from featureCounts feature
+                                   counting (fastq.featurecounts_single_end and fastq.featurecounts_paired_end).</p>
+                               </li>
+                               <li><p>The RNAlysis graphical interface should now load more quickly.</p></li>
+                               <li><p>Progress bars in the graphical interface should now reflect elapsed/remaining time
+                                   for tasks more accurately.</p></li>
+                           </ul>
+</section>
+                       <section id="id12">
+                           <h3>Fixed<a class="headerlink" href="#id12" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug in the function ‘Split into Higly and Lowly expressed genes’
+                                   (Filter.split_by_reads) where the two resulting tables would be named incorrectly
+                                   (highly-expressed genes would be labeled ‘belowXreads’ and vice-versa).</p></li>
+                               <li><p>Fixed bug where the ‘column’ parameter of some functions (‘Filter by percentile’,
+                                   ‘Split by percentile’, ‘Filter with a number filter’, ‘Filter with a text filter’)
+                                   would not automatically detect column names in the graphical interface.</p></li>
+                               <li><p>Fixed bug where the ‘numerator’ and ‘denominator’ parameters of of the function
+                                   ‘Calculate fold change’ would not automatically detect column names in the graphical
+                                   interface.</p></li>
+                               <li><p>Fixed bug where tables with integer-indices could not be visualized properly
+                                   through the graphical interface.</p></li>
+                               <li><p>Fixed bug in the function ‘featureCounts single-end’
+                                   (fastq.featurecounts_single_end) where setting parameter ‘report_read_assignment’ to
+                                   any value other than None would raise an error.</p></li>
+                               <li><p>Functions that take column name/names as input (transform, filter_missing_values,
+                                   filter_percentile, split_percentile) can now be applied to fold change tables
+                                   (FoldCangeFilter objects).</p></li>
+                               <li><p>Fixed bug where the description for the ‘n_bars’ parameter of the ‘create
+                                   enrichment bar-plot’ function (enrichment.enrichment_bar_plot) would not display
+                                   properly.</p></li>
+                               <li><p>‘Visualize gene ontology’ and ‘Visualize KEGG pathway’
+                                   (enrichment.gene_ontology_graph and enrichment.kegg_pathway_graph) now have proper
+                                   parameter descriptions.</p></li>
+                               <li><p>Fixed bug where in-place intersection and difference in the filtering module would
+                                   fail when using recent versions of pandas.</p></li>
 <li><p>Fixed bug where graphs generated through the Visualize Gene Sets window would not immediately display when using the RNAlysis stand-alone app.</p></li>
 </ul>
 </section>
 </section>
-<section id="id7">
-<h2>3.6.2 (2023-03-25)<a class="headerlink" href="#id7" title="Permalink to this heading"></a></h2>
-<p>This version introduces quality-of-life changes to the graphical interface, as well as bug fixes.</p>
-<section id="id8">
-<h3>Added<a class="headerlink" href="#id8" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Sample groupings in functions such as PCA, Pair-plot, etc., can now be imported and exported through the graphical interface.</p></li>
-</ul>
-</section>
-<section id="id9">
-<h3>Fixed<a class="headerlink" href="#id9" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where the stand-alone Mac version of RNAlysis would sometimes fail to map gene IDs (directly or in enrichment analysis).</p></li>
-</ul>
-</section>
-</section>
-<section id="id10">
-<h2>3.6.1 (2023-03-22)<a class="headerlink" href="#id10" title="Permalink to this heading"></a></h2>
-<p>This version introduces minor bug fixes.</p>
-<section id="id11">
-<h3>Changed<a class="headerlink" href="#id11" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>DESeq2 automatic installation should now work more reliably.</p></li>
-</ul>
-</section>
-<section id="id12">
-<h3>Fixed<a class="headerlink" href="#id12" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where PCA plots would not display on the stand-alone app unless another visualization function was applied afterwards.</p></li>
-<li><p>Fixed bug where Pipelines that contain specific functions (such as translating gene IDs/filtering biotypes from GTF file) would fail to run through the graphical interface.</p></li>
-<li><p>GO Annotations annotated by ComplexPortal are now supported by RNAlysis.</p></li>
-</ul>
-</section>
-</section>
-<section id="id13">
-<h2>3.6.0 (2023-03-07)<a class="headerlink" href="#id13" title="Permalink to this heading"></a></h2>
-<p>This version introduces improvements to the usability and clarity of the graphic interface,
-new methods for automatic estimation of the number of clusters in a dataset,
-and various bug fixes.</p>
-<section id="id14">
-<h3>Added<a class="headerlink" href="#id14" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added three new methods for automatic estimation of the number of clusters in a dataset: Callinski-Harabasz, Davies-Bouldin, and Bayesian Information Criterieon.</p></li>
-<li><p>Added a ‘Close all Figures’ actions to the ‘View’ menu of the <em>RNAlysis</em> graphic interface.</p></li>
-<li><p>Added an ‘interactive’ parameter to Volcano Plots (DESeqFilter.volcano_plot) and ‘Scatter Sample Vs Sample’ (CountFilter.scatter_sample_vs_sample), allowing user to label data points interactively by clicking on them.</p></li>
-<li><p>Added more optional plotting parameters to Volcano Plots (DESeqFilter.volcano_plot) and ‘Scatter Sample Vs Sample’ (CountFilter.scatter_sample_vs_sample).</p></li>
-</ul>
-</section>
-<section id="id15">
-<h3>Changed<a class="headerlink" href="#id15" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Progress bars are now integrated into the main <em>RNAlysis</em> window instead of opening as a dialog box.</p></li>
-<li><p>Information about running proccesses and functions is now displayed in the main <em>RNAlysis</em> window.</p></li>
-<li><p>It is now possible to cancel queued jobs through the <em>RNAlysis</em> graphic interface.</p></li>
-<li><p>When loading multiple data tables at the same time, it is now possible to change the table type of all data tables at once, instead of one-by-one.</p></li>
-</ul>
-</section>
-<section id="id16">
-<h3>Fixed<a class="headerlink" href="#id16" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>RNAlysis KEGG enrichment should now match the new KEGG annotation format from March 1st 2023.</p></li>
-<li><p>Fixed bug where importing <em>RNAlysis</em> would raise ImportError when cutadapt is not installed.</p></li>
-<li><p>Fixed bug where the ‘Run’ button in the Enrichment Analysis window would grey out whenever the enrichment dataset is changed.</p></li>
-<li><p>Fixed bug where the <em>RNAlysis</em> stand-alone versions were unable to export Figures in specific formats (e.g. PDF, SVG).</p></li>
-<li><p>Fixed bug where functions that depend on R scripts (such as DESeq2 and limma) would sometimes fail to run on MacOS (thanks to Matthias Wilm and <a class="reference external" href="https://github.com/sandyl27">sandyl27</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/12">#12</a>).</p></li>
-<li><p>Fixed bug where running limma-voom with a design matrix whose column names contained spaces or special characterse would raise an error.</p></li>
-<li><p>Fixed bug where the ‘highlight’ parameter of CountFilter.scatter_sample_vs_sample would not work when used through the graphic interface.</p></li>
-<li><p>Fixed bug where enrichment analysis would sometimes fail to run when ‘exclude_unannotated_genes’ is set to False.</p></li>
-<li><p>Fixed bug where translate_gene_ids() would fail for RankedSet objects.</p></li>
+                   <section id="id13">
+                       <h2>3.6.2 (2023-03-25)<a class="headerlink" href="#id13" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces quality-of-life changes to the graphical interface, as well as bug
+                           fixes.</p>
+                       <section id="id14">
+                           <h3>Added<a class="headerlink" href="#id14" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Sample groupings in functions such as PCA, Pair-plot, etc., can now be imported
+                                   and exported through the graphical interface.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id15">
+                           <h3>Fixed<a class="headerlink" href="#id15" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where the stand-alone Mac version of RNAlysis would sometimes fail to
+                                   map gene IDs (directly or in enrichment analysis).</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id16">
+                       <h2>3.6.1 (2023-03-22)<a class="headerlink" href="#id16" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces minor bug fixes.</p>
+                       <section id="id17">
+                           <h3>Changed<a class="headerlink" href="#id17" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>DESeq2 automatic installation should now work more reliably.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id18">
+                           <h3>Fixed<a class="headerlink" href="#id18" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where PCA plots would not display on the stand-alone app unless another
+                                   visualization function was applied afterwards.</p></li>
+                               <li><p>Fixed bug where Pipelines that contain specific functions (such as translating
+                                   gene IDs/filtering biotypes from GTF file) would fail to run through the graphical
+                                   interface.</p></li>
+                               <li><p>GO Annotations annotated by ComplexPortal are now supported by RNAlysis.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id19">
+                       <h2>3.6.0 (2023-03-07)<a class="headerlink" href="#id19" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces improvements to the usability and clarity of the graphic interface,
+                           new methods for automatic estimation of the number of clusters in a dataset,
+                           and various bug fixes.</p>
+                       <section id="id20">
+                           <h3>Added<a class="headerlink" href="#id20" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added three new methods for automatic estimation of the number of clusters in a
+                                   dataset: Callinski-Harabasz, Davies-Bouldin, and Bayesian Information Criterieon.</p>
+                               </li>
+                               <li><p>Added a ‘Close all Figures’ actions to the ‘View’ menu of the <em>RNAlysis</em>
+                                   graphic interface.</p></li>
+                               <li><p>Added an ‘interactive’ parameter to Volcano Plots (DESeqFilter.volcano_plot) and
+                                   ‘Scatter Sample Vs Sample’ (CountFilter.scatter_sample_vs_sample), allowing user to
+                                   label data points interactively by clicking on them.</p></li>
+                               <li><p>Added more optional plotting parameters to Volcano Plots
+                                   (DESeqFilter.volcano_plot) and ‘Scatter Sample Vs Sample’
+                                   (CountFilter.scatter_sample_vs_sample).</p></li>
+                           </ul>
+                       </section>
+                       <section id="id21">
+                           <h3>Changed<a class="headerlink" href="#id21" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Progress bars are now integrated into the main <em>RNAlysis</em> window instead of
+                                   opening as a dialog box.</p></li>
+                               <li><p>Information about running proccesses and functions is now displayed in the main
+                                   <em>RNAlysis</em> window.</p></li>
+                               <li><p>It is now possible to cancel queued jobs through the <em>RNAlysis</em> graphic
+                                   interface.</p></li>
+                               <li><p>When loading multiple data tables at the same time, it is now possible to change
+                                   the table type of all data tables at once, instead of one-by-one.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id22">
+                           <h3>Fixed<a class="headerlink" href="#id22" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>RNAlysis KEGG enrichment should now match the new KEGG annotation format from
+                                   March 1st 2023.</p></li>
+                               <li><p>Fixed bug where importing <em>RNAlysis</em> would raise ImportError when cutadapt
+                                   is not installed.</p></li>
+                               <li><p>Fixed bug where the ‘Run’ button in the Enrichment Analysis window would grey out
+                                   whenever the enrichment dataset is changed.</p></li>
+                               <li><p>Fixed bug where the <em>RNAlysis</em> stand-alone versions were unable to export
+                                   Figures in specific formats (e.g. PDF, SVG).</p></li>
+                               <li><p>Fixed bug where functions that depend on R scripts (such as DESeq2 and limma)
+                                   would sometimes fail to run on MacOS (thanks to Matthias Wilm and <a
+                                       class="reference external" href="https://github.com/sandyl27">sandyl27</a> in <a
+                                       class="reference external"
+                                       href="https://github.com/GuyTeichman/RNAlysis/issues/12">#12</a>).</p></li>
+                               <li><p>Fixed bug where running limma-voom with a design matrix whose column names
+                                   contained spaces or special characterse would raise an error.</p></li>
+                               <li><p>Fixed bug where the ‘highlight’ parameter of CountFilter.scatter_sample_vs_sample
+                                   would not work when used through the graphic interface.</p></li>
+                               <li><p>Fixed bug where enrichment analysis would sometimes fail to run when
+                                   ‘exclude_unannotated_genes’ is set to False.</p></li>
+                               <li><p>Fixed bug where translate_gene_ids() would fail for RankedSet objects.</p></li>
 <li><p>Fixed bug where filtering gene sets by user-defined attributes (FeatureSet.filter_by_attribute()) would occasionally fail to run.</p></li>
 </ul>
 </section>
-<section id="id18">
-<h3>New Contributors<a class="headerlink" href="#id18" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p><a class="reference external" href="https://github.com/sandyl27">sandyl27</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/12">#12</a></p></li>
-</ul>
-</section>
-</section>
-<section id="id19">
-<h2>3.5.2 (2023-02-23)<a class="headerlink" href="#id19" title="Permalink to this heading"></a></h2>
-<p>This version includes bug fixes for a few quality-of-life issues which were introduced in version RNAlysis 3.5.0.</p>
-<section id="id20">
-<h3>Changed<a class="headerlink" href="#id20" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>It is now possible to change the parallel backend of performance-intensive functions such as clustering an enrichment analysis in non-standalone versions of RNAlysis.</p></li>
-<li><p>Expanded the Frequently Asked Questions page.</p></li>
-<li><p>Added Perl as a dependency for Windows users on the How to Install page.</p></li>
-<li><p>Automatic row colours in column-picking tables should no longer mismatch with font colors in a way that obscures visibility.</p></li>
-</ul>
-</section>
-<section id="id21">
-<h3>Fixed<a class="headerlink" href="#id21" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where occasionally newly-created tabs would open twice instead of once.</p></li>
-<li><p>Fixed bug where the ‘Add Function’ button of the Pipeline window would appear in the wrong location.</p></li>
-<li><p>Fixed bug where RNAlysis sessions saved after version 3.5.0 which contain gene sets would raise an error when loaded.</p></li>
-<li><p>Fixed typos in the RNAlysis tutorial.</p></li>
-</ul>
-</section>
-</section>
-<section id="id22">
-<h2>3.5.1 (2023-02-22)<a class="headerlink" href="#id22" title="Permalink to this heading"></a></h2>
-<p>This version introduces minor bug fixes.</p>
-<section id="id23">
-<h3>Fixed<a class="headerlink" href="#id23" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where the <em>RNAlysis</em> stand-alone app would sometimes fail to run CutAdapt (thanks to Matthias Wilm).</p></li>
-<li><p>Fixed bug where the User Guide action in the graphical interface would point to the Tutorial, and vice versa.</p></li>
-<li><p>The X and Y axis labels on volcano plots should now format the ‘log’ in the label correctly.</p></li>
-</ul>
-</section>
-</section>
-<section id="id24">
-<h2>3.5.0 (2023-02-08)<a class="headerlink" href="#id24" title="Permalink to this heading"></a></h2>
-<p>This version introduces new features such as differential expression analysis with the Limma-Voom pipeline,
-customizable databases for the quick-search function, basic filtering and procrssing functions for gene sets,
-improved progammatic API for FeatureSet and RankedSet objects, and RPKM and TPM read count normalization.
-Several changes have been made to improve the user experience, including updated documentation,
-improved clarity of function tooltips, clearer output formats, and faster download speeds for tutorial videos.</p>
-<section id="id25">
-<h3>Added<a class="headerlink" href="#id25" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added differential expression analysis with the Limma-Voom pipelines (CountFilter.differential_expression_limma_voom)</p></li>
-<li><p>You can now select which databases to display in the right-click quick-search menu, using the settings menu.</p></li>
-<li><p>Gene sets now support some basic operations (filtering, gene ID translating, etc) through the graphical interface.</p></li>
-<li><p>enrichment.FeatureSet and enrichment.RankedSet now support some filtering operations from the filtering module (such as filtering by user-defined attributes, GO terms, or KEGG pathways).</p></li>
-<li><p>Added reads-per-kilobase-million (RPKM) and transcripts-per-million (TPM) normalization methods (CountFilter.normalize_to_rpkm() and CountFilter.normalize_to_tpm()).</p></li>
-</ul>
-</section>
-<section id="id26">
-<h3>Changed<a class="headerlink" href="#id26" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Classes enrichment.FeatureSet and enrichment.RankedSet now inherit from Python base-class set, and can be interacted with like other Python sets. The old API and attributes of these classes were maintained as they were.</p></li>
-<li><p>Improved documentation for some functions.</p></li>
-<li><p>Function selection tooltips should now display information more clearly.</p></li>
-<li><p>Pipelines that contain consecutive clustering/splitting functions will now return their outputs in a clearer format.</p></li>
-<li><p>Enrichment bar-plots should now adjust the x-axis limits more tightly to fit the displayed data.</p></li>
-<li><p>Improved clarity of automatic titles in enrichment plots.</p></li>
-<li><p>Download/update speed of tutorial videos has improved significantly.</p></li>
-</ul>
-</section>
-<section id="id27">
-<h3>Fixed<a class="headerlink" href="#id27" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where Pipelines would not always properly run ‘translate_gene_ids’</p></li>
-</ul>
-</section>
-</section>
-<section id="id28">
-<h2>3.4.2 (2023-02-01)<a class="headerlink" href="#id28" title="Permalink to this heading"></a></h2>
-<p>This version introduces minor bug fixes.</p>
-<section id="id29">
-<h3>Fixed<a class="headerlink" href="#id29" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug where updating RNAlysis through the graphical interface would not update some of the optional dependencies.</p></li>
-<li><p>Fixed typos in the documentation.</p></li>
-</ul>
-</section>
-</section>
-<section id="id30">
-<h2>3.4.0 (2023-02-01)<a class="headerlink" href="#id30" title="Permalink to this heading"></a></h2>
-<p>From this release forward, <em>RNAlysis</em> is made available as a stand-alone app for Windows and MacOS. You can download these stand-alone versions from the GitHub Releases page.
-In addition, new features were added, including new plots, filtering functions, integration of the external tools bowtie2 and featureCounts, and the ability to generate Gene Ontology Graphs and KEGG Pathway Graphs without running enrichment analysis from scratch.</p>
-<section id="id31">
-<h3>Added<a class="headerlink" href="#id31" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added a Scree Plot (explained variance per PC) to Principle Component Analysis</p></li>
-<li><p>Added CountFilter.split_by_principal_component(), allowing users to filter genes based on their contributions (loadings) to PCA Principal Components.</p></li>
-<li><p>Added Filter.drop_columns</p></li>
-<li><p>Added support for the Sharpened Cosine distance metric in clustering analyses</p></li>
-<li><p>KEGG enrichment can now generate KEGG pathway graphs for pathways that were found to be statistically significant</p></li>
-<li><p>Added functions to the enrichment module that can generate KEGG Pathway or Gene Ontology plots based on previously-generated enrichment results</p></li>
-<li><p>You can now clear the <em>RNAlysis</em> cache from the <em>RNAlysis</em> GUI, or through the general module.</p></li>
-<li><p>Added bowtie2 alignment to the fastq module.</p></li>
-<li><p>Added FeatureCounts feature-counting to the fastq module.</p></li>
+                       <section id="id24">
+                           <h3>New Contributors<a class="headerlink" href="#id24"
+                                                  title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p><a class="reference external" href="https://github.com/sandyl27">sandyl27</a> in
+                                   <a class="reference external"
+                                      href="https://github.com/GuyTeichman/RNAlysis/issues/12">#12</a></p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id25">
+                       <h2>3.5.2 (2023-02-23)<a class="headerlink" href="#id25" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version includes bug fixes for a few quality-of-life issues which were introduced in
+                           version RNAlysis 3.5.0.</p>
+                       <section id="id26">
+                           <h3>Changed<a class="headerlink" href="#id26" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>It is now possible to change the parallel backend of performance-intensive
+                                   functions such as clustering an enrichment analysis in non-standalone versions of
+                                   RNAlysis.</p></li>
+                               <li><p>Expanded the Frequently Asked Questions page.</p></li>
+                               <li><p>Added Perl as a dependency for Windows users on the How to Install page.</p></li>
+                               <li><p>Automatic row colours in column-picking tables should no longer mismatch with font
+                                   colors in a way that obscures visibility.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id27">
+                           <h3>Fixed<a class="headerlink" href="#id27" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where occasionally newly-created tabs would open twice instead of
+                                   once.</p></li>
+                               <li><p>Fixed bug where the ‘Add Function’ button of the Pipeline window would appear in
+                                   the wrong location.</p></li>
+                               <li><p>Fixed bug where RNAlysis sessions saved after version 3.5.0 which contain gene
+                                   sets would raise an error when loaded.</p></li>
+                               <li><p>Fixed typos in the RNAlysis tutorial.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id28">
+                       <h2>3.5.1 (2023-02-22)<a class="headerlink" href="#id28" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces minor bug fixes.</p>
+                       <section id="id29">
+                           <h3>Fixed<a class="headerlink" href="#id29" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where the <em>RNAlysis</em> stand-alone app would sometimes fail to run
+                                   CutAdapt (thanks to Matthias Wilm).</p></li>
+                               <li><p>Fixed bug where the User Guide action in the graphical interface would point to
+                                   the Tutorial, and vice versa.</p></li>
+                               <li><p>The X and Y axis labels on volcano plots should now format the ‘log’ in the label
+                                   correctly.</p></li>
+                           </ul>
+                       </section>
+                   </section>
+                   <section id="id30">
+                       <h2>3.5.0 (2023-02-08)<a class="headerlink" href="#id30" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces new features such as differential expression analysis with the
+                           Limma-Voom pipeline,
+                           customizable databases for the quick-search function, basic filtering and procrssing
+                           functions for gene sets,
+                           improved progammatic API for FeatureSet and RankedSet objects, and RPKM and TPM read count
+                           normalization.
+                           Several changes have been made to improve the user experience, including updated
+                           documentation,
+                           improved clarity of function tooltips, clearer output formats, and faster download speeds for
+                           tutorial videos.</p>
+                       <section id="id31">
+                           <h3>Added<a class="headerlink" href="#id31" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added differential expression analysis with the Limma-Voom pipelines
+                                   (CountFilter.differential_expression_limma_voom)</p></li>
+                               <li><p>You can now select which databases to display in the right-click quick-search
+                                   menu, using the settings menu.</p></li>
+                               <li><p>Gene sets now support some basic operations (filtering, gene ID translating, etc)
+                                   through the graphical interface.</p></li>
+                               <li><p>enrichment.FeatureSet and enrichment.RankedSet now support some filtering
+                                   operations from the filtering module (such as filtering by user-defined attributes,
+                                   GO terms, or KEGG pathways).</p></li>
+                               <li><p>Added reads-per-kilobase-million (RPKM) and transcripts-per-million (TPM)
+                                   normalization methods (CountFilter.normalize_to_rpkm() and
+                                   CountFilter.normalize_to_tpm()).</p></li>
+                           </ul>
+                       </section>
+                       <section id="id32">
+                           <h3>Changed<a class="headerlink" href="#id32" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Classes enrichment.FeatureSet and enrichment.RankedSet now inherit from Python
+                                   base-class set, and can be interacted with like other Python sets. The old API and
+                                   attributes of these classes were maintained as they were.</p></li>
+                               <li><p>Improved documentation for some functions.</p></li>
+                               <li><p>Function selection tooltips should now display information more clearly.</p></li>
+                               <li><p>Pipelines that contain consecutive clustering/splitting functions will now return
+                                   their outputs in a clearer format.</p></li>
+                               <li><p>Enrichment bar-plots should now adjust the x-axis limits more tightly to fit the
+                                   displayed data.</p></li>
+                               <li><p>Improved clarity of automatic titles in enrichment plots.</p></li>
+                               <li><p>Download/update speed of tutorial videos has improved significantly.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id33">
+                           <h3>Fixed<a class="headerlink" href="#id33" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where Pipelines would not always properly run ‘translate_gene_ids’</p>
+                               </li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id34">
+                       <h2>3.4.2 (2023-02-01)<a class="headerlink" href="#id34" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>This version introduces minor bug fixes.</p>
+                       <section id="id35">
+                           <h3>Fixed<a class="headerlink" href="#id35" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug where updating RNAlysis through the graphical interface would not update
+                                   some of the optional dependencies.</p></li>
+                               <li><p>Fixed typos in the documentation.</p></li>
+                           </ul>
+                       </section>
+                   </section>
+                   <section id="id36">
+                       <h2>3.4.0 (2023-02-01)<a class="headerlink" href="#id36" title="Permalink to this heading"></a>
+                       </h2>
+                       <p>From this release forward, <em>RNAlysis</em> is made available as a stand-alone app for
+                           Windows and MacOS. You can download these stand-alone versions from the GitHub Releases page.
+                           In addition, new features were added, including new plots, filtering functions, integration
+                           of the external tools bowtie2 and featureCounts, and the ability to generate Gene Ontology
+                           Graphs and KEGG Pathway Graphs without running enrichment analysis from scratch.</p>
+                       <section id="id37">
+                           <h3>Added<a class="headerlink" href="#id37" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added a Scree Plot (explained variance per PC) to Principle Component Analysis</p>
+                               </li>
+                               <li><p>Added CountFilter.split_by_principal_component(), allowing users to filter genes
+                                   based on their contributions (loadings) to PCA Principal Components.</p></li>
+                               <li><p>Added Filter.drop_columns</p></li>
+                               <li><p>Added support for the Sharpened Cosine distance metric in clustering analyses</p>
+                               </li>
+                               <li><p>KEGG enrichment can now generate KEGG pathway graphs for pathways that were found
+                                   to be statistically significant</p></li>
+                               <li><p>Added functions to the enrichment module that can generate KEGG Pathway or Gene
+                                   Ontology plots based on previously-generated enrichment results</p></li>
+                               <li><p>You can now clear the <em>RNAlysis</em> cache from the <em>RNAlysis</em> GUI, or
+                                   through the general module.</p></li>
+                               <li><p>Added bowtie2 alignment to the fastq module.</p></li>
+                               <li><p>Added FeatureCounts feature-counting to the fastq module.</p></li>
 <li><p>You can now choose whether or not to discard genes from enrichment analysis if they have no annotations associated with them.</p></li>
 <li><p>When right-clicking on a specific cell in a table or line in a gene set view, a context menu will open, allowing you to copy the associated value, or look it up in one of few common biology databases.</p></li>
 <li><p>Added sections to the programmatic user guide about the <cite>fastq</cite> module.</p></li>
 </ul>
 </section>
-<section id="id32">
-<h3>Changed<a class="headerlink" href="#id32" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Replaced the ‘parallel’ parameter in enrichment functions with the ‘parallel_backend’ parameter, allowing users to choose which parallel backend (if any) will be used in the function.</p></li>
-<li><p>Added ‘parallel_backend’ parameter to all clustering functions under the filtering module.</p></li>
-<li><p>When generating Gene Ontology/KEGG Pathway graphs, users can choose whether or not to generate the figure in an additional separate file.</p></li>
-<li><p>Updated type annotations of some functions to be more precise and helpful (for example, setting a lower bound on some int function parameters).</p></li>
-<li><p>The colorbar ticks in enrichment bar plots now match the axis ticks on the main axis.</p></li>
-<li><p>Slight improvements in GUI performance, stability, and looks.</p></li>
-<li><p>Slight improvements in performance of enrichment analysis when examining a small number of attributes.</p></li>
-<li><p>enrichment.plot_enrichment() was replaced by enrichment.enrichment_bar_plot().</p></li>
-<li><p>CountFilter.differential_expression() has new optional parameter <cite>output_folder</cite>, which allows users to save the generated data tables and the R script that generated them into a specified folder.</p></li>
-</ul>
-</section>
-<section id="id33">
-<h3>Fixed<a class="headerlink" href="#id33" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>In CountFilter.differential_expression_deseq2(), fixed a bug where design matrix files with non-comma delimiters would cause an error (thanks to <a class="reference external" href="https://github.com/Mintxoklet">Mintxoklet</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/7">#7</a>)</p></li>
-<li><p>Fixed bug where setup.py would install a directory named tests into site-packages folder (thanks to <a class="reference external" href="https://github.com/kbipinkumar">Bipin Kumar</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/9">#9</a>)</p></li>
-<li><p>Fixed bug where the windows of some functions (differential expression, adapter trimming, etc) did not show a link to the function’s documentation page.</p></li>
-<li><p>Fixed typos in some parts of the <em>RNAlysis</em> documentation</p></li>
-<li><p>When filtering a table by a single user-defined attribute, the automatic table name will now be more informative about the operation applied.</p></li>
-<li><p>Fixed bug where occasionally a Pipeline or Function would generate multiple tables of the same name, but only one of them will appear in the GUI.</p></li>
-<li><p>Fixed bug where occasionally significance asterisks on enrichment bar-plots would appear in the wrong location.</p></li>
-<li><p>Fixed bug where fastq.create_kallisto_index() (Create Kallisto Index) would not make use of the <cite>make_unique</cite> parameter (thanks to Matthias Wilm)</p></li>
-</ul>
+                       <section id="id38">
+                           <h3>Changed<a class="headerlink" href="#id38" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Replaced the ‘parallel’ parameter in enrichment functions with the
+                                   ‘parallel_backend’ parameter, allowing users to choose which parallel backend (if
+                                   any) will be used in the function.</p></li>
+                               <li><p>Added ‘parallel_backend’ parameter to all clustering functions under the filtering
+                                   module.</p></li>
+                               <li><p>When generating Gene Ontology/KEGG Pathway graphs, users can choose whether or not
+                                   to generate the figure in an additional separate file.</p></li>
+                               <li><p>Updated type annotations of some functions to be more precise and helpful (for
+                                   example, setting a lower bound on some int function parameters).</p></li>
+                               <li><p>The colorbar ticks in enrichment bar plots now match the axis ticks on the main
+                                   axis.</p></li>
+                               <li><p>Slight improvements in GUI performance, stability, and looks.</p></li>
+                               <li><p>Slight improvements in performance of enrichment analysis when examining a small
+                                   number of attributes.</p></li>
+                               <li><p>enrichment.plot_enrichment() was replaced by enrichment.enrichment_bar_plot().</p>
+                               </li>
+                               <li><p>CountFilter.differential_expression() has new optional parameter <cite>output_folder</cite>,
+                                   which allows users to save the generated data tables and the R script that generated
+                                   them into a specified folder.</p></li>
+</ul>
+</section>
+                       <section id="id39">
+                           <h3>Fixed<a class="headerlink" href="#id39" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>In CountFilter.differential_expression_deseq2(), fixed a bug where design matrix
+                                   files with non-comma delimiters would cause an error (thanks to <a
+                                       class="reference external" href="https://github.com/Mintxoklet">Mintxoklet</a> in
+                                   <a class="reference external"
+                                      href="https://github.com/GuyTeichman/RNAlysis/issues/7">#7</a>)</p></li>
+                               <li><p>Fixed bug where setup.py would install a directory named tests into site-packages
+                                   folder (thanks to <a class="reference external"
+                                                        href="https://github.com/kbipinkumar">Bipin Kumar</a> in <a
+                                       class="reference external"
+                                       href="https://github.com/GuyTeichman/RNAlysis/issues/9">#9</a>)</p></li>
+                               <li><p>Fixed bug where the windows of some functions (differential expression, adapter
+                                   trimming, etc) did not show a link to the function’s documentation page.</p></li>
+                               <li><p>Fixed typos in some parts of the <em>RNAlysis</em> documentation</p></li>
+                               <li><p>When filtering a table by a single user-defined attribute, the automatic table
+                                   name will now be more informative about the operation applied.</p></li>
+                               <li><p>Fixed bug where occasionally a Pipeline or Function would generate multiple tables
+                                   of the same name, but only one of them will appear in the GUI.</p></li>
+                               <li><p>Fixed bug where occasionally significance asterisks on enrichment bar-plots would
+                                   appear in the wrong location.</p></li>
+                               <li><p>Fixed bug where fastq.create_kallisto_index() (Create Kallisto Index) would not
+                                   make use of the <cite>make_unique</cite> parameter (thanks to Matthias Wilm)</p></li>
+                           </ul>
 </section>
 <section id="removed">
 <h3>Removed<a class="headerlink" href="#removed" title="Permalink to this heading"></a></h3>
@@ -542,372 +827,504 @@ <h3>Removed<a class="headerlink" href="#removed" title="Permalink to this headin
 <li><p>Removed the previously-deprecated functions <cite>enrichment.enrich_randomization()</cite> and <cite>enrichment.enrich_hypergeometric()</cite>.</p></li>
 </ul>
 </section>
-<section id="id36">
-<h3>New Contributors<a class="headerlink" href="#id36" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p><a class="reference external" href="https://github.com/Mintxoklet">Mintxoklet</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/7">#7</a></p></li>
-<li><p><a class="reference external" href="https://github.com/kbipinkumar">Bipin Kumar</a> in <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis/issues/9">#9</a></p></li>
-<li><p>Matthias Wilm</p></li>
-</ul>
-</section>
-</section>
-<section id="id37">
-<h2>3.3.0 (2022-12-02)<a class="headerlink" href="#id37" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduced quality-of-life improvements to the graphical user interface.</p></li>
-</ul>
-<section id="id38">
-<h3>Added<a class="headerlink" href="#id38" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added a Frequently Asked Questions page, and linked all <em>RNAlysis</em> help material inside the graphical interface Help menu.</p></li>
-<li><p>Pipelines can now be edited and deleted through the Pipeline menu of the graphical interface.</p></li>
-<li><p>Added Contributing page to the documentation, with basic guidelines on how you can contribute to the <em>RNAlysis</em> project!</p></li>
-</ul>
-</section>
-<section id="id39">
-<h3>Changed<a class="headerlink" href="#id39" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>All open tabs are now always visible in the main menu screen. Tab names are now shortened with ellipsis if nessecary.</p></li>
-<li><p>The right-click context menu of the main menu tabs now allows users to open a new tab at a specific position, or close a specific tab/tabs to the right/tabs to the left/all other tabs.</p></li>
-<li><p><em>RNAlysis</em> documentation is now split into GUI documentation (quick-start video guide, tutorial, GUI user guide), and programmatic documentation (programmatic user guide)</p></li>
-<li><p>Improved readability of <em>RNAlysis</em> logs</p></li>
-<li><p>Pipelines are now exported with additional metadata - the version of <em>RNAlysis</em> they were exported from, and the date and time it was exported. This metadata should not affect Pipelines that were created in older versions, and does not affect the way Pipelines are applied to data tables.</p></li>
-</ul>
-</section>
-<section id="id40">
-<h3>Fixed<a class="headerlink" href="#id40" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p><em>RNAlysis</em> now warns users if they attempt to overwrite an existing Pipeline.</p></li>
-<li><p>Fixed an incorrect keyboard shortcut for Export Pipeline action</p></li>
-</ul>
-</section>
-</section>
-<section id="id41">
-<h2>3.2.2 (2022-11-25)<a class="headerlink" href="#id41" title="Permalink to this heading"></a></h2>
-<section id="id42">
-<h3>Fixed<a class="headerlink" href="#id42" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug with DESeq2 automatic installation on Windows computers.</p></li>
-</ul>
-</section>
-</section>
-<section id="id43">
-<h2>3.2.1 (2022-11-25)<a class="headerlink" href="#id43" title="Permalink to this heading"></a></h2>
-<section id="id44">
-<h3>Changed<a class="headerlink" href="#id44" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Updated citation information for <em>RNAlysis</em></p></li>
-</ul>
-</section>
-<section id="id45">
-<h3>Fixed<a class="headerlink" href="#id45" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed typos in the <em>RNAlysis</em> tutorial</p></li>
-</ul>
-</section>
-</section>
-<section id="id46">
-<h2>3.2.0 (2022-11-23)<a class="headerlink" href="#id46" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces quality-of-life changes to the graphical user interface, functions for translating gene IDs and running differential expression analysis, and extends RNAlysis to support Python versions 3.9 and 3.10.</p></li>
-</ul>
-<section id="id47">
-<h3>Added<a class="headerlink" href="#id47" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added Filter.translate_gene_ids()</p></li>
-<li><p>Added CountFilter.differential_expression_deseq2()</p></li>
-<li><p>Added Filter.filter_by_kegg_annotations()</p></li>
-<li><p>Added Filter.filter_by_go_annotations()</p></li>
-<li><p>Added CountFilter.average_replicate_samples()</p></li>
-<li><p>Added fastq module that contains adapter-trimming functions utilizing CutAdapt, and mRNA-sequencing quantification using kallisto.</p></li>
-</ul>
-</section>
-<section id="id48">
-<h3>Changed<a class="headerlink" href="#id48" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added additional plotting parameters to visualization functions.</p></li>
-<li><p>Improved performance of some aspects of the graphical user interface.</p></li>
-<li><p>RNAlysis’ basic features are now supported on Python versions 3.9 and 3.10.</p></li>
-<li><p>CountFilter.pca() now generates a plot for <em>every</em> pair of Principal Components requested by the user.</p></li>
-<li><p>CountFilter.split_clicom() now supports clustering each batch of replicates separately, using the ‘replicates_grouping’ parameter</p></li>
-<li><p>Biotype-based filtering and summary can now be done based on GTF annotation files instead of a Biotype Reference Table.</p></li>
-<li><p>Filter.biotypes() was refactored into Filter.biotypes_from_ref_table()</p></li>
-<li><p>Filter.filter_biotype() was refactored into Filter.filter_biotype_from_ref_table()</p></li>
-</ul>
-</section>
-<section id="id49">
-<h3>Fixed<a class="headerlink" href="#id49" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Users can now queue multiple computationally-intense enrichment/clustering tasks while another task is running.</p></li>
-<li><p>Fixed a bug where sometimes some function parameters would disappear from the graphical user interface.</p></li>
-<li><p>Fixed a bug where exceptions during computationally-intense tasks would cause <em>RNAlysis</em> to crash.</p></li>
-<li><p>Auxillary windows are now properly minimized when analysis starts, and restored when analysis ends or encounters an error.</p></li>
-</ul>
-</section>
-</section>
-<section id="id50">
-<h2>3.1.0 (2022-10-16)<a class="headerlink" href="#id50" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces new count matrix normalization methods, as well as MA plots and minor bug fixes.</p></li>
-</ul>
-<section id="id51">
-<h3>Added<a class="headerlink" href="#id51" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added the visualization function ma_plot() for CountFilter</p></li>
-<li><p>Added functions for the normalization functions Relative Log Ratio (RLE), Trimmed Mean of M-values (TMM), Median of Ratios (MRN), Quantile normalization (quantile)</p></li>
-</ul>
-</section>
-<section id="id52">
-<h3>Changed<a class="headerlink" href="#id52" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>CountFilter.normalize_to_rpm() was renamed to CountFilter.normalize_to_rpm_htseqcount(), and was supplemented by the more general function for normalizing to Reads Per Million CountFilter.normalize_to_rpm()</p></li>
-</ul>
-</section>
-<section id="id53">
-<h3>Fixed<a class="headerlink" href="#id53" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed a bug where some elements of the graphical user interface would not display correctly</p></li>
-</ul>
-</section>
-</section>
-<section id="id54">
-<h2>3.0.1 (2022-10-12)<a class="headerlink" href="#id54" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version fixes a bug with displaying the tutorial videos in the graphical user interface.</p></li>
-</ul>
-</section>
-<section id="id55">
-<h2>3.0.0 (2022-10-10)<a class="headerlink" href="#id55" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces a graphical user interface for RNAlysis, as well as new functions for KEGG Pathways enrichment analysis.</p></li>
-</ul>
-<section id="id56">
-<h3>Added<a class="headerlink" href="#id56" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>RNAlysis now includes a graphical user interface</p></li>
-<li><p>Pipelines can now be imported and exported</p></li>
-<li><p>Enrichment and single-set-enrichment for KEGG pathway data</p></li>
-</ul>
-</section>
-<section id="id57">
-<h3>Changed<a class="headerlink" href="#id57" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added function FeatureSet.user_defined_enrichment(), which will replace FeatureSet.enrich_hypergeometric() and FeatureSet.enrich_randomization()</p></li>
-<li><p>Updated signature of enrichment.venn_diagram</p></li>
-<li><p>enrichment.venn_diagram and enrichment.upset_plot can now be generated on a user-supplied FIgure</p></li>
-<li><p>Clustering functions now apply a power transform to count data prior to clustering by default</p></li>
-<li><p>Non-deprecated enrichment functions no longer filter the background set by biotype by default</p></li>
-<li><p>Changed signature of CountFilter.pca, CountFilter.box_plot, CountFilter.enhanced_box_plot, CountFilter.clustergram, and CountFilter.pairplot to ensure consistency among visualization functions.</p></li>
-</ul>
-</section>
-<section id="id58">
-<h3>Fixed<a class="headerlink" href="#id58" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>enrichment.venn_diagram can now be plotted with outlines when the circles are unweighted</p></li>
-<li><p>Fixed bug in Pipeline.apply_to() where a Filter object would be returned even when the Pipeline was applied inplace</p></li>
-</ul>
-</section>
-</section>
-<section id="id59">
-<h2>2.1.1 (2022-07-05)<a class="headerlink" href="#id59" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version fixes issues with running GO enrichment that resulted from recent changes to UniProt’s API.  Moreover, this version slightly improves the performance of some functions.</p></li>
-</ul>
-<section id="id60">
-<h3>Changed<a class="headerlink" href="#id60" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed issues with running GO enrichment that resulted from changes to UniProt’s API.</p></li>
-<li><p>Some functions that fetch annotations now cache their results, leading to improved runtimes.</p></li>
-<li><p>Updated the documentation of some functions to better reflect their usage and input parameters.</p></li>
-</ul>
-</section>
-</section>
-<section id="id61">
-<h2>2.1.0 (2022-04-16)<a class="headerlink" href="#id61" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces multiple new features, as well as generally improved graphs and quality-of-life changes.</p></li>
-</ul>
-<section id="id62">
-<h3>Added<a class="headerlink" href="#id62" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>GO enrichment can now generate Ontology Graphs for the statistically significant GO terms.</p></li>
-<li><p>Added CountFilter.split_clicom(), an implementation of the CLICOM ensemble-based clustering method (Mimaroglu and Yagci 2012).</p></li>
-<li><p>Added Filter.transform(), a method that can transform your data tables with either predefined or user-defined transformations.</p></li>
-</ul>
-</section>
-<section id="id63">
-<h3>Changed<a class="headerlink" href="#id63" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>CountFilter.pairplot() now uses a logarithmic scale by default.</p></li>
-<li><p>Visually improved the graphs generated by many functions, including CountFilter.pairplot() and CountFilter.plot_expression().</p></li>
-<li><p>The clusters resulting from all clustering functions are now sorted by size instead of being sorted randomly.</p></li>
-</ul>
-</section>
-<section id="id64">
-<h3>Fixed<a class="headerlink" href="#id64" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Minor bug fixes.</p></li>
-</ul>
-</section>
-</section>
-<section id="id65">
-<h2>2.0.1 (2022-04-02)<a class="headerlink" href="#id65" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces small bug fixes, as well as a new function in the Filtering module.</p></li>
-</ul>
-<section id="id66">
-<h3>Added<a class="headerlink" href="#id66" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added Filter.majority_vote_intersection(), which returns a set/string of the features that appear in at least (majority_threhold * 100)% of the given Filter objects/sets.</p></li>
-</ul>
-</section>
-<section id="id67">
-<h3>Changed<a class="headerlink" href="#id67" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>When mapping/inferring taxon IDs during GO enrichment analysis, organisms will now be prioritized based on their taxon ID values (numerically lower IDs will be considered to be more relevant).</p></li>
-</ul>
-</section>
-<section id="id68">
-<h3>Fixed<a class="headerlink" href="#id68" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed bug that occured when mapping/inferring taxon IDs during GO enrichment analysis, where integer taxon IDs would be matched by name similarity before trying an exact ID match, leading to spurious matches.</p></li>
-<li><p>Fixed bug that occursed when plotting clustering results with style=’all’ on Python 3.8.</p></li>
-</ul>
-</section>
-</section>
-<section id="id69">
-<h2>2.0.0 (2021-12-05)<a class="headerlink" href="#id69" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces new method to cluster your read count matrices, including K-Means/Medoids clustering, Hierarchical clustering, and HDBSCAN.</p></li>
-<li><p>This version introduces many new ways to perform enrichment analysis and to visualize your results, including highly customizable GO Enrichment, enrichment based on ranked lists of genes, and enrichment for non-categorical attributes.</p></li>
-<li><p>This version introduces Pipelines - a quicker and more convenient way to apply a particular analysis pipeline to multiple Filter objects.</p></li>
-<li><p>This version improves the performance of many functions in RNAlysis, and in particular the performance of randomization tests.</p></li>
-<li><p>This version includes changes to names and signatures of some functions in the module, as elaborated below.</p></li>
-</ul>
-<section id="id70">
-<h3>Added<a class="headerlink" href="#id70" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added class Pipeline to filtering module, which applies a series of filter functions to specified Filter objects.</p></li>
-<li><p>Added CountFilter.split_kmeans(), CountFilter.split_kmedoids(), CountFilter.split_hierarchical() and CountFilter.split_hdbscan(), which split your read count matrices into clusters with similar expression patterns.</p></li>
-<li><p>Added class RankedSet to enrichment module, which accepts a ranked list of genes/features, and can perform single-list enrichment analysis</p></li>
-<li><p>Added RankedSet.single_set_enrichment(), which can perfofm single-list enrichment analysis of user-defined attributes using XL-mHG test (see <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039">Eden et al. (PLoS Comput Biol, 2007)</a>  and <a class="reference external" href="https://dx.doi.org/10.1371/journal.pone.0143196">Wagner (PLoS One, 2015)</a> ).</p></li>
-<li><p>Added FeatureSet.go_enrichment() and RankedSet.single_set_go_enrichment(), which let you compute Gene Ontology enrichment for any organism of your choice, and filter the GO annotations used according to your preferences.</p></li>
-<li><p>Added FeatureSet.enrich_hypergeometric(), which can perform enrichment analysis using the Hypergeometric Test.</p></li>
-<li><p>Added more visualization functions, such CountFilter.enhanced_box_plot().</p></li>
-<li><p>Added FeatureSet.change_set_name(), to give a new ‘set_name’ to a FeatureSet object.</p></li>
-</ul>
-</section>
-<section id="id71">
-<h3>Changed<a class="headerlink" href="#id71" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>FeatureSet.enrich_randomization_parallel() was deprecated. Instead, you can compute your enrichment analysis with parallel computing by calling FeatureSet.enrich_randomization() with the argument ‘parallel_processing=True’. Moreover, parallel session will now start automatically if one was not already active.</p></li>
-<li><p>Improved running time of enrich_randomization() about six-fold.</p></li>
-<li><p>Filter objects can be created from any delimiter-separated file format (.csv, .tsv, .txt, etc).</p></li>
-<li><p>CountFilter.pca() can now be plotted without labeled points.</p></li>
-<li><p>Filter.index_string is now sorted by the current order of indices in the Filter object, instead of by alphabetical order.</p></li>
-<li><p>CountFilter.violin_plot() now accepts a y_title argument.</p></li>
-<li><p>Added more optional arguments to visualization functions such as CountFilter.violin_plot() and CountFilter.clustergram().</p></li>
-<li><p>Automatic filenames for Filter objects should now reflect more clearly the operations that were performed.</p></li>
-<li><p>The DataFrame returned by enrich_randomization() and enrich_randomization_parallel() now contains the additional column ‘data_scale’, determined by the new optional argument ‘data_scale’.</p></li>
+                       <section id="id42">
+                           <h3>New Contributors<a class="headerlink" href="#id42"
+                                                  title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p><a class="reference external" href="https://github.com/Mintxoklet">Mintxoklet</a>
+                                   in <a class="reference external"
+                                         href="https://github.com/GuyTeichman/RNAlysis/issues/7">#7</a></p></li>
+                               <li><p><a class="reference external" href="https://github.com/kbipinkumar">Bipin
+                                   Kumar</a> in <a class="reference external"
+                                                   href="https://github.com/GuyTeichman/RNAlysis/issues/9">#9</a></p>
+                               </li>
+                               <li><p>Matthias Wilm</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id43">
+                       <h2>3.3.0 (2022-12-02)<a class="headerlink" href="#id43" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduced quality-of-life improvements to the graphical user
+                               interface.</p></li>
+                       </ul>
+                       <section id="id44">
+                           <h3>Added<a class="headerlink" href="#id44" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added a Frequently Asked Questions page, and linked all <em>RNAlysis</em> help
+                                   material inside the graphical interface Help menu.</p></li>
+                               <li><p>Pipelines can now be edited and deleted through the Pipeline menu of the graphical
+                                   interface.</p></li>
+                               <li><p>Added Contributing page to the documentation, with basic guidelines on how you can
+                                   contribute to the <em>RNAlysis</em> project!</p></li>
+                           </ul>
+                       </section>
+                       <section id="id45">
+                           <h3>Changed<a class="headerlink" href="#id45" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>All open tabs are now always visible in the main menu screen. Tab names are now
+                                   shortened with ellipsis if nessecary.</p></li>
+                               <li><p>The right-click context menu of the main menu tabs now allows users to open a new
+                                   tab at a specific position, or close a specific tab/tabs to the right/tabs to the
+                                   left/all other tabs.</p></li>
+                               <li><p><em>RNAlysis</em> documentation is now split into GUI documentation (quick-start
+                                   video guide, tutorial, GUI user guide), and programmatic documentation (programmatic
+                                   user guide)</p></li>
+                               <li><p>Improved readability of <em>RNAlysis</em> logs</p></li>
+                               <li><p>Pipelines are now exported with additional metadata - the version of
+                                   <em>RNAlysis</em> they were exported from, and the date and time it was exported.
+                                   This metadata should not affect Pipelines that were created in older versions, and
+                                   does not affect the way Pipelines are applied to data tables.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id46">
+                           <h3>Fixed<a class="headerlink" href="#id46" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p><em>RNAlysis</em> now warns users if they attempt to overwrite an existing
+                                   Pipeline.</p></li>
+                               <li><p>Fixed an incorrect keyboard shortcut for Export Pipeline action</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id47">
+                       <h2>3.2.2 (2022-11-25)<a class="headerlink" href="#id47" title="Permalink to this heading"></a>
+                       </h2>
+                       <section id="id48">
+                           <h3>Fixed<a class="headerlink" href="#id48" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug with DESeq2 automatic installation on Windows computers.</p></li>
+                           </ul>
+                       </section>
+                   </section>
+                   <section id="id49">
+                       <h2>3.2.1 (2022-11-25)<a class="headerlink" href="#id49" title="Permalink to this heading"></a>
+                       </h2>
+                       <section id="id50">
+                           <h3>Changed<a class="headerlink" href="#id50" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Updated citation information for <em>RNAlysis</em></p></li>
+                           </ul>
+                       </section>
+                       <section id="id51">
+                           <h3>Fixed<a class="headerlink" href="#id51" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed typos in the <em>RNAlysis</em> tutorial</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id52">
+                       <h2>3.2.0 (2022-11-23)<a class="headerlink" href="#id52" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces quality-of-life changes to the graphical user interface,
+                               functions for translating gene IDs and running differential expression analysis, and
+                               extends RNAlysis to support Python versions 3.9 and 3.10.</p></li>
+                       </ul>
+                       <section id="id53">
+                           <h3>Added<a class="headerlink" href="#id53" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added Filter.translate_gene_ids()</p></li>
+                               <li><p>Added CountFilter.differential_expression_deseq2()</p></li>
+                               <li><p>Added Filter.filter_by_kegg_annotations()</p></li>
+                               <li><p>Added Filter.filter_by_go_annotations()</p></li>
+                               <li><p>Added CountFilter.average_replicate_samples()</p></li>
+                               <li><p>Added fastq module that contains adapter-trimming functions utilizing CutAdapt,
+                                   and mRNA-sequencing quantification using kallisto.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id54">
+                           <h3>Changed<a class="headerlink" href="#id54" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added additional plotting parameters to visualization functions.</p></li>
+                               <li><p>Improved performance of some aspects of the graphical user interface.</p></li>
+                               <li><p>RNAlysis’ basic features are now supported on Python versions 3.9 and 3.10.</p>
+                               </li>
+                               <li><p>CountFilter.pca() now generates a plot for <em>every</em> pair of Principal
+                                   Components requested by the user.</p></li>
+                               <li><p>CountFilter.split_clicom() now supports clustering each batch of replicates
+                                   separately, using the ‘replicates_grouping’ parameter</p></li>
+                               <li><p>Biotype-based filtering and summary can now be done based on GTF annotation files
+                                   instead of a Biotype Reference Table.</p></li>
+                               <li><p>Filter.biotypes() was refactored into Filter.biotypes_from_ref_table()</p></li>
+                               <li><p>Filter.filter_biotype() was refactored into
+                                   Filter.filter_biotype_from_ref_table()</p></li>
+                           </ul>
+</section>
+                       <section id="id55">
+                           <h3>Fixed<a class="headerlink" href="#id55" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Users can now queue multiple computationally-intense enrichment/clustering tasks
+                                   while another task is running.</p></li>
+                               <li><p>Fixed a bug where sometimes some function parameters would disappear from the
+                                   graphical user interface.</p></li>
+                               <li><p>Fixed a bug where exceptions during computationally-intense tasks would cause <em>RNAlysis</em>
+                                   to crash.</p></li>
+                               <li><p>Auxillary windows are now properly minimized when analysis starts, and restored
+                                   when analysis ends or encounters an error.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id56">
+                       <h2>3.1.0 (2022-10-16)<a class="headerlink" href="#id56" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces new count matrix normalization methods, as well as MA plots
+                               and minor bug fixes.</p></li>
+                       </ul>
+                       <section id="id57">
+                           <h3>Added<a class="headerlink" href="#id57" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added the visualization function ma_plot() for CountFilter</p></li>
+                               <li><p>Added functions for the normalization functions Relative Log Ratio (RLE), Trimmed
+                                   Mean of M-values (TMM), Median of Ratios (MRN), Quantile normalization (quantile)</p>
+                               </li>
+                           </ul>
+                       </section>
+                       <section id="id58">
+                           <h3>Changed<a class="headerlink" href="#id58" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>CountFilter.normalize_to_rpm() was renamed to
+                                   CountFilter.normalize_to_rpm_htseqcount(), and was supplemented by the more general
+                                   function for normalizing to Reads Per Million CountFilter.normalize_to_rpm()</p></li>
+                           </ul>
+                       </section>
+                       <section id="id59">
+                           <h3>Fixed<a class="headerlink" href="#id59" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed a bug where some elements of the graphical user interface would not display
+                                   correctly</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id60">
+                       <h2>3.0.1 (2022-10-12)<a class="headerlink" href="#id60" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version fixes a bug with displaying the tutorial videos in the graphical user
+                               interface.</p></li>
+                       </ul>
+                   </section>
+                   <section id="id61">
+                       <h2>3.0.0 (2022-10-10)<a class="headerlink" href="#id61" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces a graphical user interface for RNAlysis, as well as new
+                               functions for KEGG Pathways enrichment analysis.</p></li>
+                       </ul>
+                       <section id="id62">
+                           <h3>Added<a class="headerlink" href="#id62" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>RNAlysis now includes a graphical user interface</p></li>
+                               <li><p>Pipelines can now be imported and exported</p></li>
+                               <li><p>Enrichment and single-set-enrichment for KEGG pathway data</p></li>
+                           </ul>
+                       </section>
+                       <section id="id63">
+                           <h3>Changed<a class="headerlink" href="#id63" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added function FeatureSet.user_defined_enrichment(), which will replace
+                                   FeatureSet.enrich_hypergeometric() and FeatureSet.enrich_randomization()</p></li>
+                               <li><p>Updated signature of enrichment.venn_diagram</p></li>
+                               <li><p>enrichment.venn_diagram and enrichment.upset_plot can now be generated on a
+                                   user-supplied FIgure</p></li>
+                               <li><p>Clustering functions now apply a power transform to count data prior to clustering
+                                   by default</p></li>
+                               <li><p>Non-deprecated enrichment functions no longer filter the background set by biotype
+                                   by default</p></li>
+                               <li><p>Changed signature of CountFilter.pca, CountFilter.box_plot,
+                                   CountFilter.enhanced_box_plot, CountFilter.clustergram, and CountFilter.pairplot to
+                                   ensure consistency among visualization functions.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id64">
+                           <h3>Fixed<a class="headerlink" href="#id64" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>enrichment.venn_diagram can now be plotted with outlines when the circles are
+                                   unweighted</p></li>
+                               <li><p>Fixed bug in Pipeline.apply_to() where a Filter object would be returned even when
+                                   the Pipeline was applied inplace</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id65">
+                       <h2>2.1.1 (2022-07-05)<a class="headerlink" href="#id65" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version fixes issues with running GO enrichment that resulted from recent changes
+                               to UniProt’s API. Moreover, this version slightly improves the performance of some
+                               functions.</p></li>
+                       </ul>
+                       <section id="id66">
+                           <h3>Changed<a class="headerlink" href="#id66" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed issues with running GO enrichment that resulted from changes to UniProt’s
+                                   API.</p></li>
+                               <li><p>Some functions that fetch annotations now cache their results, leading to improved
+                                   runtimes.</p></li>
+                               <li><p>Updated the documentation of some functions to better reflect their usage and
+                                   input parameters.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id67">
+                       <h2>2.1.0 (2022-04-16)<a class="headerlink" href="#id67" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces multiple new features, as well as generally improved graphs
+                               and quality-of-life changes.</p></li>
+                       </ul>
+                       <section id="id68">
+                           <h3>Added<a class="headerlink" href="#id68" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>GO enrichment can now generate Ontology Graphs for the statistically significant
+                                   GO terms.</p></li>
+                               <li><p>Added CountFilter.split_clicom(), an implementation of the CLICOM ensemble-based
+                                   clustering method (Mimaroglu and Yagci 2012).</p></li>
+                               <li><p>Added Filter.transform(), a method that can transform your data tables with either
+                                   predefined or user-defined transformations.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id69">
+                           <h3>Changed<a class="headerlink" href="#id69" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>CountFilter.pairplot() now uses a logarithmic scale by default.</p></li>
+                               <li><p>Visually improved the graphs generated by many functions, including
+                                   CountFilter.pairplot() and CountFilter.plot_expression().</p></li>
+                               <li><p>The clusters resulting from all clustering functions are now sorted by size
+                                   instead of being sorted randomly.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id70">
+                           <h3>Fixed<a class="headerlink" href="#id70" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Minor bug fixes.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id71">
+                       <h2>2.0.1 (2022-04-02)<a class="headerlink" href="#id71" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces small bug fixes, as well as a new function in the Filtering
+                               module.</p></li>
+                       </ul>
+                       <section id="id72">
+                           <h3>Added<a class="headerlink" href="#id72" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added Filter.majority_vote_intersection(), which returns a set/string of the
+                                   features that appear in at least (majority_threhold * 100)% of the given Filter
+                                   objects/sets.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id73">
+                           <h3>Changed<a class="headerlink" href="#id73" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>When mapping/inferring taxon IDs during GO enrichment analysis, organisms will now
+                                   be prioritized based on their taxon ID values (numerically lower IDs will be
+                                   considered to be more relevant).</p></li>
+                           </ul>
+                       </section>
+                       <section id="id74">
+                           <h3>Fixed<a class="headerlink" href="#id74" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed bug that occured when mapping/inferring taxon IDs during GO enrichment
+                                   analysis, where integer taxon IDs would be matched by name similarity before trying
+                                   an exact ID match, leading to spurious matches.</p></li>
+                               <li><p>Fixed bug that occursed when plotting clustering results with style=’all’ on
+                                   Python 3.8.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id75">
+                       <h2>2.0.0 (2021-12-05)<a class="headerlink" href="#id75" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces new method to cluster your read count matrices, including
+                               K-Means/Medoids clustering, Hierarchical clustering, and HDBSCAN.</p></li>
+                           <li><p>This version introduces many new ways to perform enrichment analysis and to visualize
+                               your results, including highly customizable GO Enrichment, enrichment based on ranked
+                               lists of genes, and enrichment for non-categorical attributes.</p></li>
+                           <li><p>This version introduces Pipelines - a quicker and more convenient way to apply a
+                               particular analysis pipeline to multiple Filter objects.</p></li>
+                           <li><p>This version improves the performance of many functions in RNAlysis, and in particular
+                               the performance of randomization tests.</p></li>
+                           <li><p>This version includes changes to names and signatures of some functions in the module,
+                               as elaborated below.</p></li>
+                       </ul>
+                       <section id="id76">
+                           <h3>Added<a class="headerlink" href="#id76" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added class Pipeline to filtering module, which applies a series of filter
+                                   functions to specified Filter objects.</p></li>
+                               <li><p>Added CountFilter.split_kmeans(), CountFilter.split_kmedoids(),
+                                   CountFilter.split_hierarchical() and CountFilter.split_hdbscan(), which split your
+                                   read count matrices into clusters with similar expression patterns.</p></li>
+                               <li><p>Added class RankedSet to enrichment module, which accepts a ranked list of
+                                   genes/features, and can perform single-list enrichment analysis</p></li>
+                               <li><p>Added RankedSet.single_set_enrichment(), which can perfofm single-list enrichment
+                                   analysis of user-defined attributes using XL-mHG test (see <a
+                                       class="reference external"
+                                       href="https://dx.doi.org/10.1371/journal.pcbi.0030039">Eden et al. (PLoS Comput
+                                       Biol, 2007)</a> and <a class="reference external"
+                                                              href="https://dx.doi.org/10.1371/journal.pone.0143196">Wagner
+                                       (PLoS One, 2015)</a> ).</p></li>
+                               <li><p>Added FeatureSet.go_enrichment() and RankedSet.single_set_go_enrichment(), which
+                                   let you compute Gene Ontology enrichment for any organism of your choice, and filter
+                                   the GO annotations used according to your preferences.</p></li>
+                               <li><p>Added FeatureSet.enrich_hypergeometric(), which can perform enrichment analysis
+                                   using the Hypergeometric Test.</p></li>
+                               <li><p>Added more visualization functions, such CountFilter.enhanced_box_plot().</p></li>
+                               <li><p>Added FeatureSet.change_set_name(), to give a new ‘set_name’ to a FeatureSet
+                                   object.</p></li>
+                           </ul>
+</section>
+                       <section id="id77">
+                           <h3>Changed<a class="headerlink" href="#id77" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>FeatureSet.enrich_randomization_parallel() was deprecated. Instead, you can
+                                   compute your enrichment analysis with parallel computing by calling
+                                   FeatureSet.enrich_randomization() with the argument ‘parallel_processing=True’.
+                                   Moreover, parallel session will now start automatically if one was not already
+                                   active.</p></li>
+                               <li><p>Improved running time of enrich_randomization() about six-fold.</p></li>
+                               <li><p>Filter objects can be created from any delimiter-separated file format (.csv,
+                                   .tsv, .txt, etc).</p></li>
+                               <li><p>CountFilter.pca() can now be plotted without labeled points.</p></li>
+                               <li><p>Filter.index_string is now sorted by the current order of indices in the Filter
+                                   object, instead of by alphabetical order.</p></li>
+                               <li><p>CountFilter.violin_plot() now accepts a y_title argument.</p></li>
+                               <li><p>Added more optional arguments to visualization functions such as
+                                   CountFilter.violin_plot() and CountFilter.clustergram().</p></li>
+                               <li><p>Automatic filenames for Filter objects should now reflect more clearly the
+                                   operations that were performed.</p></li>
+                               <li><p>The DataFrame returned by enrich_randomization() and
+                                   enrich_randomization_parallel() now contains the additional column ‘data_scale’,
+                                   determined by the new optional argument ‘data_scale’.</p></li>
 <li><p>The columns ‘n obs’ and ‘n exp’ in the DataFrame returned by enrich_randomization() and enrich_randomization_parallel() were renamed to ‘obs’ and ‘exp’ respectively.</p></li>
 <li><p>FeatureSets no longer support in-place set operations (intersection, union, difference, symmetric difference). Instead, these functions return a new FeatureSet.</p></li>
 <li><p>Filter.biotypes_from_ref_table() now accepts the boolean parameter ‘long_format’ instead of the str parameter ‘format’.</p></li>
 <li><p>Filter.biotypes_from_ref_table() and FeatureSet.biotypes_from_ref_table() now count features which do not appear in the Biotype Reference Table as ‘_missing_from_biotype_reference’ instead of ‘not_in_biotype_reference’.</p></li>
 </ul>
 </section>
-<section id="id72">
-<h3>Fixed<a class="headerlink" href="#id72" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Updated type-hinting of specific functions.</p></li>
-<li><p>Filter.biotypes_from_ref_table() and FeatureSet.biotypes_from_ref_table() now support Biotype Reference Tables with different column names.</p></li>
-<li><p>Generally improved performance of RNAlysis.</p></li>
-<li><p>Fixed bug in Filter.filter_percentile() where the value at the exact percentile speficied (e.g. the median for percentile=0.5) would be removed from the Filter object.</p></li>
-<li><p>Fixed bug in enrichment.FeatureSet, where creating a FeatureSet from input string would result in an empty set.</p></li>
-<li><p>Various minor bug fixes.</p></li>
-</ul>
-</section>
-</section>
-<section id="id73">
-<h2>1.3.5 (2020-05-27)<a class="headerlink" href="#id73" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version introduces minor bug fixes and a few more visualization options.</p></li>
-</ul>
-<section id="id74">
-<h3>Added<a class="headerlink" href="#id74" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added Filter.filter_missing_values(), which can remove rows with NaN values in some (or all) columns.</p></li>
-<li><p>Added the visualization function CountFilter.box_plot().</p></li>
-</ul>
-</section>
-<section id="id75">
-<h3>Changed<a class="headerlink" href="#id75" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Updated docstrings and printouts of several functions.</p></li>
-<li><p>Slightly improved speed and performance across the board.</p></li>
-<li><p>Filter.feature_string() is now sorted alphabetically.</p></li>
-<li><p>Enrichment randomization functions in the enrichment module now accept a ‘random_seed’ argument, to be able to generate consistent results over multiple sessions.</p></li>
-<li><p>Enrichment randomization functions can now return the matplotlib Figure object, in addition to the results table.</p></li>
-</ul>
-</section>
-<section id="id76">
-<h3>Fixed<a class="headerlink" href="#id76" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed DepracationWarning on parsing functions from the general module.</p></li>
-<li><p>Fixed bug where saving csv files on Linux systems would save the files under the wrong directory.</p></li>
-<li><p>Fixed a bug where UTF-8-encoded Reference Tables won’t be loaded correctly</p></li>
-<li><p>Fixed a bug where enrichment.upsetplot() and enrichment.venn_diagram() would sometimes modify the user dict input ‘objs’.</p></li>
-<li><p>Fixed a bug in CountFilter.pairplot where log2 would be calculated without a pseudocount added, leading to division by 0.</p></li>
-</ul>
-</section>
-</section>
-<section id="id77">
-<h2>1.3.4 (2020-04-07)<a class="headerlink" href="#id77" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>This version fixed a bug that prevented installation of the package.</p></li>
-</ul>
-<section id="id78">
-<h3>Changed<a class="headerlink" href="#id78" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Updated docstrings and printouts of several functions</p></li>
-</ul>
-</section>
-<section id="id79">
-<h3>Fixed<a class="headerlink" href="#id79" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Fixed a bug with installation of the previous version</p></li>
-</ul>
-</section>
-</section>
-<section id="id80">
-<h2>1.3.3 (2020-03-28)<a class="headerlink" href="#id80" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>First stable release on PyPI.</p></li>
-</ul>
-<section id="id81">
-<h3>Added<a class="headerlink" href="#id81" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Added Filter.sort(), and upgraded the functionality of Filter.filter_top_n().</p></li>
-<li><p>Added UpSet plots and Venn diagrams to enrichment module.</p></li>
-<li><p>User-defined biotype reference tables can now be used.</p></li>
-<li><p>Filter operations now print out the result of the operation.</p></li>
-<li><p>Enrichment randomization tests now also support non-WBGene indexing.</p></li>
-<li><p>Filter.biotypes_from_ref_table() and FeatureSet.biotypes_from_ref_table() now report genes that don’t appear in the biotype reference table.</p></li>
-<li><p>Filter.biotypes_from_ref_table() can now give a long-form report with descriptive statistics of all columns, grouped by biotype.</p></li>
-<li><p>Added code examples to the user guide and to the docstrings of most functions.</p></li>
-</ul>
-</section>
-<section id="id82">
-<h3>Changed<a class="headerlink" href="#id82" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Changed argument order and default values in filtering.CountFilter.from_folder_htseqcount().</p></li>
-<li><p>Changed default title in scatter_sample_vs_sample().</p></li>
-<li><p>Changed default filename in CountFilter.fold_change().</p></li>
-<li><p>Settings are now saved in a .yaml format. Reading and writing of settings have been modified.</p></li>
-<li><p>Changed argument name ‘deseq_highlight’ to ‘highlight’ in scatter_sample_vs_sample(). It can now accept any Filter object.</p></li>
-<li><p>Updated documentation and default ‘mode’ value for FeatureSet.go_enrichment().</p></li>
-<li><p>Updated the signature and function of general.load_csv() to be clearer and more predictable.</p></li>
-<li><p>Changed argument names in CountFilter.from_folder_htseqcount().</p></li>
-<li><p>Modified names and signatures of .csv test files functions to make them more comprehensible.</p></li>
+                       <section id="id78">
+                           <h3>Fixed<a class="headerlink" href="#id78" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Updated type-hinting of specific functions.</p></li>
+                               <li><p>Filter.biotypes_from_ref_table() and FeatureSet.biotypes_from_ref_table() now
+                                   support Biotype Reference Tables with different column names.</p></li>
+                               <li><p>Generally improved performance of RNAlysis.</p></li>
+                               <li><p>Fixed bug in Filter.filter_percentile() where the value at the exact percentile
+                                   speficied (e.g. the median for percentile=0.5) would be removed from the Filter
+                                   object.</p></li>
+                               <li><p>Fixed bug in enrichment.FeatureSet, where creating a FeatureSet from input string
+                                   would result in an empty set.</p></li>
+                               <li><p>Various minor bug fixes.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id79">
+                       <h2>1.3.5 (2020-05-27)<a class="headerlink" href="#id79" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version introduces minor bug fixes and a few more visualization options.</p></li>
+                       </ul>
+                       <section id="id80">
+                           <h3>Added<a class="headerlink" href="#id80" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added Filter.filter_missing_values(), which can remove rows with NaN values in
+                                   some (or all) columns.</p></li>
+                               <li><p>Added the visualization function CountFilter.box_plot().</p></li>
+                           </ul>
+                       </section>
+                       <section id="id81">
+                           <h3>Changed<a class="headerlink" href="#id81" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Updated docstrings and printouts of several functions.</p></li>
+                               <li><p>Slightly improved speed and performance across the board.</p></li>
+                               <li><p>Filter.feature_string() is now sorted alphabetically.</p></li>
+                               <li><p>Enrichment randomization functions in the enrichment module now accept a
+                                   ‘random_seed’ argument, to be able to generate consistent results over multiple
+                                   sessions.</p></li>
+                               <li><p>Enrichment randomization functions can now return the matplotlib Figure object, in
+                                   addition to the results table.</p></li>
+                           </ul>
+                       </section>
+                       <section id="id82">
+                           <h3>Fixed<a class="headerlink" href="#id82" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed DepracationWarning on parsing functions from the general module.</p></li>
+                               <li><p>Fixed bug where saving csv files on Linux systems would save the files under the
+                                   wrong directory.</p></li>
+                               <li><p>Fixed a bug where UTF-8-encoded Reference Tables won’t be loaded correctly</p>
+                               </li>
+                               <li><p>Fixed a bug where enrichment.upsetplot() and enrichment.venn_diagram() would
+                                   sometimes modify the user dict input ‘objs’.</p></li>
+                               <li><p>Fixed a bug in CountFilter.pairplot where log2 would be calculated without a
+                                   pseudocount added, leading to division by 0.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id83">
+                       <h2>1.3.4 (2020-04-07)<a class="headerlink" href="#id83" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>This version fixed a bug that prevented installation of the package.</p></li>
+                       </ul>
+                       <section id="id84">
+                           <h3>Changed<a class="headerlink" href="#id84" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Updated docstrings and printouts of several functions</p></li>
+                           </ul>
+                       </section>
+                       <section id="id85">
+                           <h3>Fixed<a class="headerlink" href="#id85" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Fixed a bug with installation of the previous version</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id86">
+                       <h2>1.3.3 (2020-03-28)<a class="headerlink" href="#id86" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>First stable release on PyPI.</p></li>
+                       </ul>
+                       <section id="id87">
+                           <h3>Added<a class="headerlink" href="#id87" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Added Filter.sort(), and upgraded the functionality of Filter.filter_top_n().</p>
+                               </li>
+                               <li><p>Added UpSet plots and Venn diagrams to enrichment module.</p></li>
+                               <li><p>User-defined biotype reference tables can now be used.</p></li>
+                               <li><p>Filter operations now print out the result of the operation.</p></li>
+                               <li><p>Enrichment randomization tests now also support non-WBGene indexing.</p></li>
+                               <li><p>Filter.biotypes_from_ref_table() and FeatureSet.biotypes_from_ref_table() now
+                                   report genes that don’t appear in the biotype reference table.</p></li>
+                               <li><p>Filter.biotypes_from_ref_table() can now give a long-form report with descriptive
+                                   statistics of all columns, grouped by biotype.</p></li>
+                               <li><p>Added code examples to the user guide and to the docstrings of most functions.</p>
+                               </li>
+                           </ul>
+</section>
+                       <section id="id88">
+                           <h3>Changed<a class="headerlink" href="#id88" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Changed argument order and default values in
+                                   filtering.CountFilter.from_folder_htseqcount().</p></li>
+                               <li><p>Changed default title in scatter_sample_vs_sample().</p></li>
+                               <li><p>Changed default filename in CountFilter.fold_change().</p></li>
+                               <li><p>Settings are now saved in a .yaml format. Reading and writing of settings have
+                                   been modified.</p></li>
+                               <li><p>Changed argument name ‘deseq_highlight’ to ‘highlight’ in
+                                   scatter_sample_vs_sample(). It can now accept any Filter object.</p></li>
+                               <li><p>Updated documentation and default ‘mode’ value for FeatureSet.go_enrichment().</p>
+                               </li>
+                               <li><p>Updated the signature and function of general.load_csv() to be clearer and more
+                                   predictable.</p></li>
+                               <li><p>Changed argument names in CountFilter.from_folder_htseqcount().</p></li>
+                               <li><p>Modified names and signatures of .csv test files functions to make them more
+                                   comprehensible.</p></li>
 <li><p>Renamed ‘Filter.filter_by_ref_table_attr()’ to ‘Filter.filter_by_attribute()’.</p></li>
 <li><p>Renamed ‘Filter.split_by_ref_table_attr()’ to ‘Filter.split_by_attribute()’.</p></li>
 <li><p>Renamed ‘Filter.norm_reads_with_size_factor()’ to ‘Filter.normalize_with_scaling_factors()’. It can now use any set of scaling factors to normalize libraries.</p></li>
@@ -915,25 +1332,26 @@ <h3>Changed<a class="headerlink" href="#id82" title="Permalink to this heading">
 <li><p>Made some functions in the general module hidden.</p></li>
 </ul>
 </section>
-<section id="id83">
-<h3>Fixed<a class="headerlink" href="#id83" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Various bug fixes</p></li>
-</ul>
-</section>
-<section id="id84">
-<h3>Removed<a class="headerlink" href="#id84" title="Permalink to this heading"></a></h3>
-<ul class="simple">
-<li><p>Removed the ‘feature_name_to_wbgene’ module from RNAlysis.</p></li>
-</ul>
-</section>
-</section>
-<section id="id85">
-<h2>1.3.2 (2019-12-11)<a class="headerlink" href="#id85" title="Permalink to this heading"></a></h2>
-<ul class="simple">
-<li><p>First beta release on PyPI.</p></li>
-</ul>
-</section>
+                       <section id="id89">
+                           <h3>Fixed<a class="headerlink" href="#id89" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Various bug fixes</p></li>
+                           </ul>
+                       </section>
+                       <section id="id90">
+                           <h3>Removed<a class="headerlink" href="#id90" title="Permalink to this heading"></a></h3>
+                           <ul class="simple">
+                               <li><p>Removed the ‘feature_name_to_wbgene’ module from RNAlysis.</p></li>
+                           </ul>
+                       </section>
+</section>
+                   <section id="id91">
+                       <h2>1.3.2 (2019-12-11)<a class="headerlink" href="#id91" title="Permalink to this heading"></a>
+                       </h2>
+                       <ul class="simple">
+                           <li><p>First beta release on PyPI.</p></li>
+                       </ul>
+                   </section>
 </section>
 
 
@@ -953,7 +1371,7 @@ <h2>1.3.2 (2019-12-11)<a class="headerlink" href="#id85" title="Permalink to thi
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     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-   
+
 
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         </div>
@@ -964,7 +1382,7 @@ <h2>1.3.2 (2019-12-11)<a class="headerlink" href="#id85" title="Permalink to thi
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
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-  </script> 
+  </script>
 
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-</html>
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+</html>
diff --git a/docs/build/index.html b/docs/build/index.html
index cf9a290b..1bd357bf 100644
--- a/docs/build/index.html
+++ b/docs/build/index.html
@@ -4,14 +4,14 @@
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   <section id="rnalysis-release-documentation">
-<h1>RNAlysis 3.8.0 documentation<a class="headerlink" href="#rnalysis-release-documentation" title="Permalink to this heading"></a></h1>
+      <h1>RNAlysis 3.9.0 documentation<a class="headerlink" href="#rnalysis-release-documentation"
+                                         title="Permalink to this heading"></a></h1>
 <a class="reference external image-reference" href="https://guyteichman.github.io/RNAlysis"><img alt="logo" src="https://raw.githubusercontent.com/GuyTeichman/RNAlysis/master/docs/source/logo.png" style="width: 400px;" /></a>
 <p><strong>Useful links:</strong> <a class="reference external" href="https://guyteichman.github.io/RNAlysis">Documentation</a> |
 <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis">Source code</a> |
@@ -202,33 +203,35 @@ <h1>RNAlysis 3.8.0 documentation<a class="headerlink" href="#rnalysis-release-do
 <div class="toctree-wrapper compound">
 <p class="caption" role="heading"><span class="caption-text">Change history:</span></p>
 <ul>
-<li class="toctree-l1"><a class="reference internal" href="history.html">History</a><ul>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id1">3.8.0 (2023-05-07)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id3">3.7.0 (2023-04-07)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id7">3.6.2 (2023-03-25)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id10">3.6.1 (2023-03-22)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id13">3.6.0 (2023-03-07)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id19">3.5.2 (2023-02-23)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id22">3.5.1 (2023-02-22)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id24">3.5.0 (2023-02-08)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id28">3.4.2 (2023-02-01)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id30">3.4.0 (2023-02-01)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id37">3.3.0 (2022-12-02)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id41">3.2.2 (2022-11-25)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id43">3.2.1 (2022-11-25)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id46">3.2.0 (2022-11-23)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id50">3.1.0 (2022-10-16)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id54">3.0.1 (2022-10-12)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id55">3.0.0 (2022-10-10)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id59">2.1.1 (2022-07-05)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id61">2.1.0 (2022-04-16)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id65">2.0.1 (2022-04-02)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id69">2.0.0 (2021-12-05)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id73">1.3.5 (2020-05-27)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id77">1.3.4 (2020-04-07)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id80">1.3.3 (2020-03-28)</a></li>
-<li class="toctree-l2"><a class="reference internal" href="history.html#id85">1.3.2 (2019-12-11)</a></li>
-</ul>
+<li class="toctree-l1"><a class="reference internal" href="history.html">History</a>
+    <ul>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id1">3.9.0 (2023-06-09)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id3">3.8.0 (2023-05-07)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id9">3.7.0 (2023-04-07)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id13">3.6.2 (2023-03-25)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id16">3.6.1 (2023-03-22)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id19">3.6.0 (2023-03-07)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id25">3.5.2 (2023-02-23)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id28">3.5.1 (2023-02-22)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id30">3.5.0 (2023-02-08)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id34">3.4.2 (2023-02-01)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id36">3.4.0 (2023-02-01)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id43">3.3.0 (2022-12-02)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id47">3.2.2 (2022-11-25)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id49">3.2.1 (2022-11-25)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id52">3.2.0 (2022-11-23)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id56">3.1.0 (2022-10-16)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id60">3.0.1 (2022-10-12)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id61">3.0.0 (2022-10-10)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id65">2.1.1 (2022-07-05)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id67">2.1.0 (2022-04-16)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id71">2.0.1 (2022-04-02)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id75">2.0.0 (2021-12-05)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id79">1.3.5 (2020-05-27)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id83">1.3.4 (2020-04-07)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id86">1.3.3 (2020-03-28)</a></li>
+        <li class="toctree-l2"><a class="reference internal" href="history.html#id91">1.3.2 (2019-12-11)</a></li>
+    </ul>
 </li>
 </ul>
 </div>
@@ -280,7 +283,7 @@ <h2>Modules:<a class="headerlink" href="#modules" title="Permalink to this headi
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+
 
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index 153028d6..150c5529 100644
--- a/docs/build/py-modindex.html
+++ b/docs/build/py-modindex.html
@@ -3,7 +3,7 @@
 <head>
   <meta charset="utf-8" />
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>Python Module Index &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>Python Module Index &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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diff --git a/docs/build/quick_start.html b/docs/build/quick_start.html
index d40b4e2a..cd74c9c0 100644
--- a/docs/build/quick_start.html
+++ b/docs/build/quick_start.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>RNAlysis quick-start video guide &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>RNAlysis quick-start video guide &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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diff --git a/docs/build/readme.html b/docs/build/readme.html
index 9fe9584e..32cd6695 100644
--- a/docs/build/readme.html
+++ b/docs/build/readme.html
@@ -4,29 +4,29 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>What is RNAlysis? &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>What is RNAlysis? &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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   <!--[if lt IE 9]>
     <script src="_static/js/html5shiv.min.js"></script>
   <![endif]-->
-  
+
         <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
-        <script src="_static/jquery.js"></script>
-        <script src="_static/underscore.js"></script>
-        <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
-        <script src="_static/doctools.js"></script>
-        <script src="_static/sphinx_highlight.js"></script>
-        <script src="_static/copybutton.js"></script>
+    <script src="_static/jquery.js"></script>
+    <script src="_static/underscore.js"></script>
+    <script src="_static/_sphinx_javascript_frameworks_compat.js"></script>
+    <script src="_static/doctools.js"></script>
+    <script src="_static/sphinx_highlight.js"></script>
+    <script src="_static/copybutton.js"></script>
     <script src="_static/js/theme.js"></script>
-    <link rel="index" title="Index" href="genindex.html" />
-    <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="How can I contribute to RNAlysis?" href="contributing.html" />
-    <link rel="prev" title="RNAlysis 3.8.0 documentation" href="index.html" /> 
+    <link rel="index" title="Index" href="genindex.html"/>
+    <link rel="search" title="Search" href="search.html"/>
+    <link rel="next" title="How can I contribute to RNAlysis?" href="contributing.html"/>
+    <link rel="prev" title="RNAlysis 3.9.0 documentation" href="index.html"/>
 </head>
 
-<body class="wy-body-for-nav"> 
+<body class="wy-body-for-nav">
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -108,7 +108,7 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-             
+
   <a class="reference external image-reference" href="https://guyteichman.github.io/RNAlysis"><img alt="logo" src="https://raw.githubusercontent.com/GuyTeichman/RNAlysis/master/docs/source/logo.png" style="width: 400px;" /></a>
 <p><strong>Useful links:</strong> <a class="reference external" href="https://guyteichman.github.io/RNAlysis">Documentation</a> |
 <a class="reference external" href="https://github.com/GuyTeichman/RNAlysis">Source code</a> |
@@ -250,12 +250,25 @@ <h2>How do I cite <em>RNAlysis</em>?<a class="headerlink" href="#how-do-i-cite-r
 </pre></div>
 </div>
 <p>If you use the <em>HDBSCAN</em> clustering feature in your research, please cite:</p>
-<div class="highlight-default notranslate"><div class="highlight"><pre><span></span> <span class="n">L</span><span class="o">.</span> <span class="n">McInnes</span><span class="p">,</span> <span class="n">J</span><span class="o">.</span> <span class="n">Healy</span><span class="p">,</span> <span class="n">S</span><span class="o">.</span> <span class="n">Astels</span><span class="p">,</span> <span class="n">hdbscan</span><span class="p">:</span>
-<span class="n">Hierarchical</span> <span class="n">density</span> <span class="n">based</span> <span class="n">clustering</span> <span class="n">In</span><span class="p">:</span>
-<span class="n">Journal</span> <span class="n">of</span> <span class="n">Open</span> <span class="n">Source</span> <span class="n">Software</span><span class="p">,</span> <span class="n">The</span> <span class="n">Open</span> <span class="n">Journal</span><span class="p">,</span> <span class="n">volume</span> <span class="mi">2</span><span class="p">,</span> <span class="n">number</span> <span class="mf">11.</span> <span class="mi">2017</span>
-<span class="n">https</span><span class="p">:</span><span class="o">//</span><span class="n">doi</span><span class="o">.</span><span class="n">org</span><span class="o">/</span><span class="mf">10.1371</span><span class="o">/</span><span class="n">journal</span><span class="o">.</span><span class="n">pcbi</span><span class="mf">.0030039</span>
-</pre></div>
-</div>
+    <div class="highlight-default notranslate">
+        <div class="highlight"><pre><span></span> <span class="n">L</span><span class="o">.</span> <span class="n">McInnes</span><span
+            class="p">,</span> <span class="n">J</span><span class="o">.</span> <span class="n">Healy</span><span
+            class="p">,</span> <span class="n">S</span><span class="o">.</span> <span class="n">Astels</span><span
+            class="p">,</span> <span class="n">hdbscan</span><span class="p">:</span> <span
+            class="n">Hierarchical</span> <span class="n">density</span> <span class="n">based</span> <span class="n">clustering</span> <span
+            class="n">In</span><span class="p">:</span>
+<span class="n">Journal</span> <span class="n">of</span> <span class="n">Open</span> <span class="n">Source</span> <span
+                class="n">Software</span><span class="p">,</span> <span class="n">The</span> <span class="n">Open</span> <span
+                class="n">Journal</span><span class="p">,</span> <span class="n">volume</span> <span class="mi">2</span><span
+                class="p">,</span> <span class="n">number</span> <span class="mf">11.</span> <span
+                class="mi">2017</span>
+<span class="n">https</span><span class="p">:</span><span class="o">//</span><span class="n">doi</span><span
+                class="o">.</span><span class="n">org</span><span class="o">/</span><span class="mf">10.1371</span><span
+                class="o">/</span><span class="n">journal</span><span class="o">.</span><span class="n">pcbi</span><span
+                class="mf">.0030039</span>
+</pre>
+        </div>
+    </div>
 <p>If you use the <em>XL-mHG</em> single-set enrichment test in your research, please cite:</p>
 <div class="highlight-default notranslate"><div class="highlight"><pre><span></span><span class="n">Eden</span><span class="p">,</span> <span class="n">E</span><span class="o">.</span><span class="p">,</span> <span class="n">Lipson</span><span class="p">,</span> <span class="n">D</span><span class="o">.</span><span class="p">,</span> <span class="n">Yogev</span><span class="p">,</span> <span class="n">S</span><span class="o">.</span><span class="p">,</span> <span class="ow">and</span> <span class="n">Yakhini</span><span class="p">,</span> <span class="n">Z</span><span class="o">.</span> <span class="p">(</span><span class="mi">2007</span><span class="p">)</span><span class="o">.</span>
  <span class="n">Discovering</span> <span class="n">Motifs</span> <span class="ow">in</span> <span class="n">Ranked</span> <span class="n">Lists</span> <span class="n">of</span> <span class="n">DNA</span> <span class="n">Sequences</span><span class="o">.</span> <span class="n">PLOS</span> <span class="n">Comput</span><span class="o">.</span> <span class="n">Biol</span><span class="o">.</span> <span class="mi">3</span><span class="p">,</span> <span class="n">e39</span><span class="o">.</span>
@@ -284,6 +297,7 @@ <h2>Contributors<a class="headerlink" href="#contributors" title="Permalink to t
 <li><p>Matthias Wilm</p></li>
 <li><p><a class="reference external" href="https://github.com/sandyl27">sandyl27</a></p></li>
 <li><p><a class="reference external" href="https://github.com/clockgene">clockgene</a></p></li>
+    <li><p><a class="reference external" href="https://github.com/NeuroRookie">NeuroRookie</a></p></li>
 </ul>
 <hr class="docutils" />
 <p>This package was created with <a class="reference external" href="https://github.com/audreyr/cookiecutter">Cookiecutter</a> and the <a class="reference external" href="https://github.com/audreyr/cookiecutter-pypackage">audreyr/cookiecutter-pypackage</a> project template.</p>
@@ -294,7 +308,8 @@ <h2>Contributors<a class="headerlink" href="#contributors" title="Permalink to t
            </div>
           </div>
           <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
-        <a href="index.html" class="btn btn-neutral float-left" title="RNAlysis 3.8.0 documentation" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
+              <a href="index.html" class="btn btn-neutral float-left" title="RNAlysis 3.9.0 documentation" accesskey="p"
+                 rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
         <a href="contributing.html" class="btn btn-neutral float-right" title="How can I contribute to RNAlysis?" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
     </div>
 
@@ -307,7 +322,7 @@ <h2>Contributors<a class="headerlink" href="#contributors" title="Permalink to t
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-   
+
 
 </footer>
         </div>
@@ -318,7 +333,7 @@ <h2>Contributors<a class="headerlink" href="#contributors" title="Permalink to t
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script> 
+  </script>
 
 </body>
-</html>
\ No newline at end of file
+</html>
diff --git a/docs/build/rnalysis.enrichment.FeatureSet.add.html b/docs/build/rnalysis.enrichment.FeatureSet.add.html
index 3bc9a400..90681597 100644
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@@ -4,7 +4,7 @@
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-  <title>rnalysis.enrichment.FeatureSet.add &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.add &mdash; RNAlysis 3.9.0 documentation</title>
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index 4be72315..4317a5ea 100644
--- a/docs/build/rnalysis.enrichment.FeatureSet.biotypes_from_ref_table.html
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-  <title>rnalysis.enrichment.FeatureSet.biotypes_from_ref_table &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.biotypes_from_ref_table &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.change_set_name.html b/docs/build/rnalysis.enrichment.FeatureSet.change_set_name.html
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+  <title>rnalysis.enrichment.FeatureSet.clear &mdash; RNAlysis 3.9.0 documentation</title>
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index 8feab0ec..3295c580 100644
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-  <title>rnalysis.enrichment.FeatureSet.copy &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.copy &mdash; RNAlysis 3.9.0 documentation</title>
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index 78eef7ea..a07602c2 100644
--- a/docs/build/rnalysis.enrichment.FeatureSet.difference.html
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-  <title>rnalysis.enrichment.FeatureSet.difference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.difference &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.difference_update.html b/docs/build/rnalysis.enrichment.FeatureSet.difference_update.html
index b88cf16f..13ef46ac 100644
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+  <title>rnalysis.enrichment.FeatureSet.difference_update &mdash; RNAlysis 3.9.0 documentation</title>
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index 760e8f20..4b6863f2 100644
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index 7f053973..5ce389e5 100644
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index 4a837012..c69488b1 100644
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index 27476bbd..73f12ea4 100644
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index 0e36b4ad..bd32d5dc 100644
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-  <title>rnalysis.enrichment.FeatureSet.go_enrichment &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.go_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -153,7 +153,7 @@
 <h1>rnalysis.enrichment.FeatureSet.go_enrichment<a class="headerlink" href="#rnalysis-enrichment-featureset-go-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.FeatureSet.go_enrichment">
-<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.go_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.go_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Gene Ontology (GO) terms against a background set.         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -198,6 +198,10 @@ <h1>rnalysis.enrichment.FeatureSet.go_enrichment<a class="headerlink" href="#rna
 :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
 :type plot_horizontal: bool (default=True)
 :param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
+:param show_expected: if True, the observed/expected values will be shown on the plot.
+:type show_expected: bool (default=False)
+:param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.
+:type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
 :type random_seed: non-negative integer (default=None)
 :type random_seed: if using a randomization test, determine the random seed used to initialize         the pseudorandom generator for the randomization test.         By default it is picked at random, but you can set it to a particular integer to get consistents results         over multiple runs. If not using a randomization test, this parameter will not affect the analysis.
 :param randomization_reps: if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.
diff --git a/docs/build/rnalysis.enrichment.FeatureSet.html b/docs/build/rnalysis.enrichment.FeatureSet.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.isdisjoint.html b/docs/build/rnalysis.enrichment.FeatureSet.isdisjoint.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.issubset.html b/docs/build/rnalysis.enrichment.FeatureSet.issubset.html
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-  <title>rnalysis.enrichment.FeatureSet.issubset &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.issubset &mdash; RNAlysis 3.9.0 documentation</title>
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-  <title>rnalysis.enrichment.FeatureSet.issuperset &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.issuperset &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.kegg_enrichment.html b/docs/build/rnalysis.enrichment.FeatureSet.kegg_enrichment.html
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+  <title>rnalysis.enrichment.FeatureSet.kegg_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -153,7 +153,7 @@
 <h1>rnalysis.enrichment.FeatureSet.kegg_enrichment<a class="headerlink" href="#rnalysis-enrichment-featureset-kegg-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.FeatureSet.kegg_enrichment">
-<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.kegg_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.kegg_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways against a background set.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -171,6 +171,8 @@ <h1>rnalysis.enrichment.FeatureSet.kegg_enrichment<a class="headerlink" href="#r
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
 <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.save_txt.html b/docs/build/rnalysis.enrichment.FeatureSet.save_txt.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.symmetric_difference.html b/docs/build/rnalysis.enrichment.FeatureSet.symmetric_difference.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.symmetric_difference_update.html b/docs/build/rnalysis.enrichment.FeatureSet.symmetric_difference_update.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.translate_gene_ids.html b/docs/build/rnalysis.enrichment.FeatureSet.translate_gene_ids.html
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.union.html b/docs/build/rnalysis.enrichment.FeatureSet.union.html
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+  <title>rnalysis.enrichment.FeatureSet.union &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.update.html b/docs/build/rnalysis.enrichment.FeatureSet.update.html
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-  <title>rnalysis.enrichment.FeatureSet.update &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.FeatureSet.update &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.FeatureSet.user_defined_enrichment.html b/docs/build/rnalysis.enrichment.FeatureSet.user_defined_enrichment.html
index e6670207..e4833a46 100644
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@@ -153,7 +153,7 @@
 <h1>rnalysis.enrichment.FeatureSet.user_defined_enrichment<a class="headerlink" href="#rnalysis-enrichment-featureset-user-defined-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.FeatureSet.user_defined_enrichment">
-<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.user_defined_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">FeatureSet.</span></span><span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.FeatureSet.user_defined_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for user-defined attributes against a background set.        The attributes are drawn from an Attribute Reference Table.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -171,6 +171,8 @@ <h1>rnalysis.enrichment.FeatureSet.user_defined_enrichment<a class="headerlink"
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot. Otherwise, results         will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
 <li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
 </ul>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.filter_by_go_annotations.html b/docs/build/rnalysis.enrichment.RankedSet.filter_by_go_annotations.html
index 54ff07fe..81ccae1c 100644
--- a/docs/build/rnalysis.enrichment.RankedSet.filter_by_go_annotations.html
+++ b/docs/build/rnalysis.enrichment.RankedSet.filter_by_go_annotations.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.RankedSet.filter_by_go_annotations &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.filter_by_go_annotations &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.filter_by_kegg_annotations.html b/docs/build/rnalysis.enrichment.RankedSet.filter_by_kegg_annotations.html
index 0a015def..fe1bd034 100644
--- a/docs/build/rnalysis.enrichment.RankedSet.filter_by_kegg_annotations.html
+++ b/docs/build/rnalysis.enrichment.RankedSet.filter_by_kegg_annotations.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.RankedSet.filter_by_kegg_annotations &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.filter_by_kegg_annotations &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.go_enrichment.html b/docs/build/rnalysis.enrichment.RankedSet.go_enrichment.html
index b915376a..94208e11 100644
--- a/docs/build/rnalysis.enrichment.RankedSet.go_enrichment.html
+++ b/docs/build/rnalysis.enrichment.RankedSet.go_enrichment.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.RankedSet.go_enrichment &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.go_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
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       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -156,7 +156,7 @@
 <h1>rnalysis.enrichment.RankedSet.go_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-go-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.go_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.go_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.go_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Gene Ontology (GO) terms against a background set.         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -201,6 +201,10 @@ <h1>rnalysis.enrichment.RankedSet.go_enrichment<a class="headerlink" href="#rnal
 :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
 :type plot_horizontal: bool (default=True)
 :param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
+:param show_expected: if True, the observed/expected values will be shown on the plot.
+:type show_expected: bool (default=False)
+:param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.
+:type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
 :type random_seed: non-negative integer (default=None)
 :type random_seed: if using a randomization test, determine the random seed used to initialize         the pseudorandom generator for the randomization test.         By default it is picked at random, but you can set it to a particular integer to get consistents results         over multiple runs. If not using a randomization test, this parameter will not affect the analysis.
 :param randomization_reps: if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.
diff --git a/docs/build/rnalysis.enrichment.RankedSet.html b/docs/build/rnalysis.enrichment.RankedSet.html
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 <h1>rnalysis.enrichment.RankedSet.kegg_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-kegg-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.kegg_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.kegg_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.kegg_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways against a background set.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -174,6 +174,8 @@ <h1>rnalysis.enrichment.RankedSet.kegg_enrichment<a class="headerlink" href="#rn
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
 <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
diff --git a/docs/build/rnalysis.enrichment.RankedSet.non_categorical_enrichment.html b/docs/build/rnalysis.enrichment.RankedSet.non_categorical_enrichment.html
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+  <title>rnalysis.enrichment.RankedSet.pop &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.remove.html b/docs/build/rnalysis.enrichment.RankedSet.remove.html
index 4dae2206..c58e0dc9 100644
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-  <title>rnalysis.enrichment.RankedSet.remove &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.remove &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.save_txt.html b/docs/build/rnalysis.enrichment.RankedSet.save_txt.html
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-  <title>rnalysis.enrichment.RankedSet.save_txt &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.save_txt &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.single_set_enrichment.html b/docs/build/rnalysis.enrichment.RankedSet.single_set_enrichment.html
index b4978365..294f61a6 100644
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-  <title>rnalysis.enrichment.RankedSet.single_set_enrichment &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.single_set_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -156,7 +156,7 @@
 <h1>rnalysis.enrichment.RankedSet.single_set_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-single-set-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.single_set_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for user-defined attributes         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The attributes are drawn from an Attribute Reference Table.         P-values are calculated using using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
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@@ -156,7 +156,7 @@
 <h1>rnalysis.enrichment.RankedSet.single_set_go_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-single-set-go-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.single_set_go_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_go_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_go_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Gene Ontology (GO) terms         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -193,6 +193,10 @@ <h1>rnalysis.enrichment.RankedSet.single_set_go_enrichment<a class="headerlink"
 :param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
 :type plot_horizontal: bool (default=True)
 :param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
+:param show_expected: if True, the observed/expected values will be shown on the plot.
+:type show_expected: bool (default=False)
+:param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.
+:type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
 :type plot_ontology_graph: bool (default=True)
 :param plot_ontology_graph: if True, will generate an ontology graph depicting the         significant GO terms and their parent nodes.
 :type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or None (default=None)
diff --git a/docs/build/rnalysis.enrichment.RankedSet.single_set_kegg_enrichment.html b/docs/build/rnalysis.enrichment.RankedSet.single_set_kegg_enrichment.html
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+++ b/docs/build/rnalysis.enrichment.RankedSet.single_set_kegg_enrichment.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.RankedSet.single_set_kegg_enrichment &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.single_set_kegg_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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@@ -156,7 +156,7 @@
 <h1>rnalysis.enrichment.RankedSet.single_set_kegg_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-single-set-kegg-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.single_set_kegg_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_kegg_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.single_set_kegg_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways WITHOUT a background set, using the generalized Minimum Hypergeometric Test         (XL-mHG, developed by <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -170,6 +170,8 @@ <h1>rnalysis.enrichment.RankedSet.single_set_kegg_enrichment<a class="headerlink
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default),         fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
 <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
 <li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
diff --git a/docs/build/rnalysis.enrichment.RankedSet.symmetric_difference.html b/docs/build/rnalysis.enrichment.RankedSet.symmetric_difference.html
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-  <title>rnalysis.enrichment.RankedSet.symmetric_difference &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.symmetric_difference_update.html b/docs/build/rnalysis.enrichment.RankedSet.symmetric_difference_update.html
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-  <title>rnalysis.enrichment.RankedSet.symmetric_difference_update &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.symmetric_difference_update &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.translate_gene_ids.html b/docs/build/rnalysis.enrichment.RankedSet.translate_gene_ids.html
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--- a/docs/build/rnalysis.enrichment.RankedSet.translate_gene_ids.html
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-  <title>rnalysis.enrichment.RankedSet.translate_gene_ids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.translate_gene_ids &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.union.html b/docs/build/rnalysis.enrichment.RankedSet.union.html
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-  <title>rnalysis.enrichment.RankedSet.union &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.union &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.update.html b/docs/build/rnalysis.enrichment.RankedSet.update.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.RankedSet.update &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.RankedSet.update &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.enrichment.RankedSet.user_defined_enrichment.html b/docs/build/rnalysis.enrichment.RankedSet.user_defined_enrichment.html
index 8b096b8b..adba9262 100644
--- a/docs/build/rnalysis.enrichment.RankedSet.user_defined_enrichment.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
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+  <title>rnalysis.enrichment.RankedSet.user_defined_enrichment &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -156,7 +156,7 @@
 <h1>rnalysis.enrichment.RankedSet.user_defined_enrichment<a class="headerlink" href="#rnalysis-enrichment-rankedset-user-defined-enrichment" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.enrichment.RankedSet.user_defined_enrichment">
-<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.user_defined_enrichment" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">RankedSet.</span></span><span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.enrichment.RankedSet.user_defined_enrichment" title="Permalink to this definition"></a></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for user-defined attributes against a background set.        The attributes are drawn from an Attribute Reference Table.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -174,6 +174,8 @@ <h1>rnalysis.enrichment.RankedSet.user_defined_enrichment<a class="headerlink" h
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot. Otherwise, results         will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
 <li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
 </ul>
diff --git a/docs/build/rnalysis.enrichment.enrichment_bar_plot.html b/docs/build/rnalysis.enrichment.enrichment_bar_plot.html
index d994c242..111df193 100644
--- a/docs/build/rnalysis.enrichment.enrichment_bar_plot.html
+++ b/docs/build/rnalysis.enrichment.enrichment_bar_plot.html
@@ -4,14 +4,14 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.enrichment.enrichment_bar_plot &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.enrichment.enrichment_bar_plot &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
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         <script src="_static/jquery.js"></script>
         <script src="_static/underscore.js"></script>
@@ -23,10 +23,10 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.enrichment.gene_ontology_graph" href="rnalysis.enrichment.gene_ontology_graph.html" />
-    <link rel="prev" title="rnalysis.enrichment.RankedSet.user_defined_enrichment" href="rnalysis.enrichment.RankedSet.user_defined_enrichment.html" /> 
+    <link rel="prev" title="rnalysis.enrichment.RankedSet.user_defined_enrichment" href="rnalysis.enrichment.RankedSet.user_defined_enrichment.html" />
 </head>
 
-<body class="wy-body-for-nav"> 
+<body class="wy-body-for-nav">
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
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@@ -116,26 +116,114 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-             
+
   <section id="rnalysis-enrichment-enrichment-bar-plot">
 <h1>rnalysis.enrichment.enrichment_bar_plot<a class="headerlink" href="#rnalysis-enrichment-enrichment-bar-plot" title="Permalink to this heading"></a></h1>
 <dl class="py function">
-<dt class="sig sig-object py" id="rnalysis.enrichment.enrichment_bar_plot">
-<span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span><a class="headerlink" href="#rnalysis.enrichment.enrichment_bar_plot" title="Permalink to this definition"></a></dt>
+    <dt class="sig sig-object py" id="rnalysis.enrichment.enrichment_bar_plot">
+        <span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span
+        class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em
+        class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span
+        class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+        class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span
+        class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span
+        class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span
+        class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span
+        class="p"><span class="pre">[</span></span><span class="s"><span
+        class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span
+        class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span
+        class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span
+        class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span
+        class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span
+        class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span
+        class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span
+        class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span
+        class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span
+        class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span
+        class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span
+        class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span
+        class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span
+        class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>,
+        <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span
+            class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span
+            class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span
+            class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span
+            class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span
+            class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span
+            class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+            class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span
+        class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span
+        class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span
+        class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span
+        class="pre">,</span></span><span class="w"> </span><span class="s"><span
+        class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span
+        class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span
+        class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span
+        class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span
+        class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span
+        class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span>
+        <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span
+            class="pre">Figure</span></span></span><a class="headerlink" href="#rnalysis.enrichment.enrichment_bar_plot"
+                                                      title="Permalink to this definition"></a></dt>
 <dd><p>Generate an enrichment bar-plot based on an enrichment results table.     For the clarity of display, complete depletion (linear enrichment = 0)     appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
-<dd class="field-odd"><ul class="simple">
-<li><p><strong>results_table_path</strong> (<em>str</em><em> or </em><em>Path</em>) – Path to the results table returned by enrichment functions.</p></li>
-<li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – the threshold for statistical significance. Used to draw significance asterisks on the graph.</p></li>
-<li><p><strong>enrichment_score_column</strong> (<em>str</em><em> (</em><em>default='log2_fold_enrichment'</em><em>)</em>) – name of the table column containing enrichment scores.</p></li>
-<li><p><strong>n_bars</strong> (<em>int &gt; 1</em><em> or </em><em>'all'</em><em> (</em><em>default='all'</em><em>)</em>) – number of bars to display in the bar plot. If n_bars=’all’,      all the results will be displayed on the graph. Otherwise, only the top n results will be displayed on the graph.</p></li>
-<li><p><strong>title</strong> (<em>str</em>) – plot title.</p></li>
-<li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
-<li><p><strong>ylabel</strong> (<em>str</em><em> (</em><em>default=r&quot;$log_2$</em><em>(</em><em>Fold Enrichment</em><em>)</em><em>&quot;</em><em>)</em>) – plot y-axis label.</p></li>
-<li><p><strong>center_bars</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, center the bars around Y=0. Otherwise, ylim is determined by min/max values.</p></li>
-<li><p><strong>ylim</strong> (<em>float</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – set the Y-axis limits. If <cite>ylim`=’auto’, determines the axis limits automatically based on the data.     If `ylim</cite> is a number, set the Y-axis limits to [-ylim, ylim].</p></li>
-</ul>
+<dd class="field-odd">
+    <ul class="simple">
+        <li><p><strong>results_table_path</strong> (<em>str</em><em> or </em><em>Path</em>) – Path to the results table
+            returned by enrichment functions.</p></li>
+        <li><p><strong>alpha</strong> (<em>float between 0 and 1</em><em> (</em><em>default=0.05</em><em>)</em>) – the
+            threshold for statistical significance. Used to draw significance asterisks on the graph.</p></li>
+        <li><p><strong>enrichment_score_column</strong> (<em>str</em><em>
+            (</em><em>default='log2_fold_enrichment'</em><em>)</em>) – name of the table column containing enrichment
+            scores.</p></li>
+        <li><p><strong>n_bars</strong> (<em>int &gt; 1</em><em> or </em><em>'all'</em><em>
+            (</em><em>default='all'</em><em>)</em>) – number of bars to display in the bar plot. If n_bars=’all’, all
+            the results will be displayed on the graph. Otherwise, only the top n results will be displayed on the
+            graph.</p></li>
+        <li><p><strong>title</strong> (<em>str</em>) – plot title.</p></li>
+        <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True,
+            results will be plotted with a horizontal bar plot. Otherwise, results will be plotted with a vertical plot.
+        </p></li>
+        <li><p><strong>ylabel</strong> (<em>str</em><em> (</em><em>default=r&quot;$log_2$</em><em>(</em><em>Fold
+            Enrichment</em><em>)</em><em>&quot;</em><em>)</em>) – plot y-axis label.</p></li>
+        <li><p><strong>center_bars</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, center
+            the bars around Y=0. Otherwise, ylim is determined by min/max values.</p></li>
+        <li><p><strong>ylim</strong> (<em>float</em><em> or </em><em>'auto'</em><em>
+            (</em><em>default='auto'</em><em>)</em>) – set the Y-axis limits. If <cite>ylim`=’auto’, determines the axis
+            limits automatically based on the data. If `ylim</cite> is a number, set the Y-axis limits to [-ylim, ylim].
+        </p></li>
+        <li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em>
+            (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for
+            a lollipop plot in which the lollipop size indicates the size of the observed gene set.</p></li>
+        <li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the
+            observed/expected values will be shown on the plot.</p></li>
+    </ul>
 </dd>
 <dt class="field-even">Returns</dt>
 <dd class="field-even"><p>Figure object containing the bar plot</p>
@@ -165,7 +253,7 @@ <h1>rnalysis.enrichment.enrichment_bar_plot<a class="headerlink" href="#rnalysis
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-  <title>rnalysis.filtering.CountFilter.describe &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.describe &mdash; RNAlysis 3.9.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.difference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.difference &mdash; RNAlysis 3.9.0 documentation</title>
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index 41648bc3..fd636234 100644
--- a/docs/build/rnalysis.filtering.CountFilter.differential_expression_deseq2.html
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-  <title>rnalysis.filtering.CountFilter.differential_expression_deseq2 &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.differential_expression_deseq2 &mdash; RNAlysis 3.9.0 documentation</title>
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index 626e43fe..eb7da067 100644
--- a/docs/build/rnalysis.filtering.CountFilter.differential_expression_limma_voom.html
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-  <title>rnalysis.filtering.CountFilter.differential_expression_limma_voom &mdash; RNAlysis 3.8.0 documentation</title>
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index 507d829d..daf1ec2b 100644
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-  <title>rnalysis.filtering.CountFilter.drop_columns &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.drop_columns &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.enhanced_box_plot.html b/docs/build/rnalysis.filtering.CountFilter.enhanced_box_plot.html
index ceb082ad..3297564a 100644
--- a/docs/build/rnalysis.filtering.CountFilter.enhanced_box_plot.html
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-  <title>rnalysis.filtering.CountFilter.enhanced_box_plot &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.enhanced_box_plot &mdash; RNAlysis 3.9.0 documentation</title>
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index 05997040..9d861779 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_biotype_from_gtf.html
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-  <title>rnalysis.filtering.CountFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.filter_biotype_from_ref_table.html b/docs/build/rnalysis.filtering.CountFilter.filter_biotype_from_ref_table.html
index a34d1a4c..e2c79145 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_biotype_from_ref_table.html
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-  <title>rnalysis.filtering.CountFilter.filter_biotype_from_ref_table &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_biotype_from_ref_table &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.filter_by_attribute.html b/docs/build/rnalysis.filtering.CountFilter.filter_by_attribute.html
index 6ebe111e..9dc651ac 100644
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-  <title>rnalysis.filtering.CountFilter.filter_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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-  <title>rnalysis.filtering.CountFilter.filter_by_kegg_annotations &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_by_kegg_annotations &mdash; RNAlysis 3.9.0 documentation</title>
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index 08ffff69..97156612 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_by_row_name.html
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-  <title>rnalysis.filtering.CountFilter.filter_by_row_name &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_by_row_name &mdash; RNAlysis 3.9.0 documentation</title>
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--- a/docs/build/rnalysis.filtering.CountFilter.filter_by_row_sum.html
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-  <title>rnalysis.filtering.CountFilter.filter_by_row_sum &mdash; RNAlysis 3.8.0 documentation</title>
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index 523fe8b0..b6cdf791 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_duplicate_ids.html
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-  <title>rnalysis.filtering.CountFilter.filter_duplicate_ids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_duplicate_ids &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.filter_low_reads.html b/docs/build/rnalysis.filtering.CountFilter.filter_low_reads.html
index d1450118..70cc99e6 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_low_reads.html
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-  <title>rnalysis.filtering.CountFilter.filter_low_reads &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_low_reads &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.filter_missing_values.html b/docs/build/rnalysis.filtering.CountFilter.filter_missing_values.html
index 6e4a05e9..045a6385 100644
--- a/docs/build/rnalysis.filtering.CountFilter.filter_missing_values.html
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-  <title>rnalysis.filtering.CountFilter.filter_missing_values &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_missing_values &mdash; RNAlysis 3.9.0 documentation</title>
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index f0509736..5b711ced 100644
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-  <title>rnalysis.filtering.CountFilter.filter_percentile &mdash; RNAlysis 3.8.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.filter_top_n.html b/docs/build/rnalysis.filtering.CountFilter.filter_top_n.html
index 1308c8c2..4a264449 100644
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-  <title>rnalysis.filtering.CountFilter.filter_top_n &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.filter_top_n &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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index 6da4d23e..ccb97a07 100644
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-  <title>rnalysis.filtering.CountFilter.fold_change &mdash; RNAlysis 3.8.0 documentation</title>
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index 18bcc4cd..6593e381 100644
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-  <title>rnalysis.filtering.CountFilter.from_dataframe &mdash; RNAlysis 3.8.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.from_folder.html b/docs/build/rnalysis.filtering.CountFilter.from_folder.html
index a461ea49..256ba545 100644
--- a/docs/build/rnalysis.filtering.CountFilter.from_folder.html
+++ b/docs/build/rnalysis.filtering.CountFilter.from_folder.html
@@ -4,7 +4,7 @@
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-  <title>rnalysis.filtering.CountFilter.from_folder &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.from_folder &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.from_folder_htseqcount.html b/docs/build/rnalysis.filtering.CountFilter.from_folder_htseqcount.html
index 102e3ed2..53a1eea7 100644
--- a/docs/build/rnalysis.filtering.CountFilter.from_folder_htseqcount.html
+++ b/docs/build/rnalysis.filtering.CountFilter.from_folder_htseqcount.html
@@ -4,7 +4,7 @@
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-  <title>rnalysis.filtering.CountFilter.from_folder_htseqcount &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.from_folder_htseqcount &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.head.html b/docs/build/rnalysis.filtering.CountFilter.head.html
index a6845874..954f043e 100644
--- a/docs/build/rnalysis.filtering.CountFilter.head.html
+++ b/docs/build/rnalysis.filtering.CountFilter.head.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.head &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.head &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.html b/docs/build/rnalysis.filtering.CountFilter.html
index 80e71dac..ae4b5bc2 100644
--- a/docs/build/rnalysis.filtering.CountFilter.html
+++ b/docs/build/rnalysis.filtering.CountFilter.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
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@@ -371,6 +373,12 @@ <h1>rnalysis.filtering.CountFilter<a class="headerlink" href="#rnalysis-filterin
 <tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html#rnalysis.filtering.CountFilter.save_csv" title="rnalysis.filtering.CountFilter.save_csv"><code class="xref py py-obj docutils literal notranslate"><span class="pre">CountFilter.save_csv</span></code></a>([alt_filename])</p></td>
 <td><p>Saves the current filtered data to a .csv file.</p></td>
 </tr>
+<tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html#rnalysis.filtering.CountFilter.save_parquet" title="rnalysis.filtering.CountFilter.save_parquet"><code class="xref py py-obj docutils literal notranslate"><span class="pre">CountFilter.save_parquet</span></code></a>([alt_filename])</p></td>
+<td><p>Saves the current filtered data to a .parquet file.</p></td>
+</tr>
+<tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html#rnalysis.filtering.CountFilter.save_table" title="rnalysis.filtering.CountFilter.save_table"><code class="xref py py-obj docutils literal notranslate"><span class="pre">CountFilter.save_table</span></code></a>([suffix, alt_filename])</p></td>
+<td><p>Save the current filtered data table.</p></td>
+</tr>
 <tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html#rnalysis.filtering.CountFilter.scatter_sample_vs_sample" title="rnalysis.filtering.CountFilter.scatter_sample_vs_sample"><code class="xref py py-obj docutils literal notranslate"><span class="pre">CountFilter.scatter_sample_vs_sample</span></code></a>(...[, ...])</p></td>
 <td><p>Generate a scatter plot where every dot is a feature, the x value is log10 of reads         (counts, RPM, RPKM, TPM, etc) in sample1, the y value is log10 of reads in sample2.</p></td>
 </tr>
diff --git a/docs/build/rnalysis.filtering.CountFilter.intersection.html b/docs/build/rnalysis.filtering.CountFilter.intersection.html
index 216b8a2d..e42fde4a 100644
--- a/docs/build/rnalysis.filtering.CountFilter.intersection.html
+++ b/docs/build/rnalysis.filtering.CountFilter.intersection.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.intersection &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.ma_plot.html b/docs/build/rnalysis.filtering.CountFilter.ma_plot.html
index a878b2e5..37e172f5 100644
--- a/docs/build/rnalysis.filtering.CountFilter.ma_plot.html
+++ b/docs/build/rnalysis.filtering.CountFilter.ma_plot.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.ma_plot &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.ma_plot &mdash; RNAlysis 3.9.0 documentation</title>
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       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.majority_vote_intersection.html b/docs/build/rnalysis.filtering.CountFilter.majority_vote_intersection.html
index cf075021..91e82bc6 100644
--- a/docs/build/rnalysis.filtering.CountFilter.majority_vote_intersection.html
+++ b/docs/build/rnalysis.filtering.CountFilter.majority_vote_intersection.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.majority_vote_intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.majority_vote_intersection &mdash; RNAlysis 3.9.0 documentation</title>
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       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.normalize_median_of_ratios.html b/docs/build/rnalysis.filtering.CountFilter.normalize_median_of_ratios.html
index 942f15b3..4989d370 100644
--- a/docs/build/rnalysis.filtering.CountFilter.normalize_median_of_ratios.html
+++ b/docs/build/rnalysis.filtering.CountFilter.normalize_median_of_ratios.html
@@ -4,7 +4,7 @@
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-  <title>rnalysis.filtering.CountFilter.normalize_median_of_ratios &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.normalize_median_of_ratios &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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@@ -122,6 +122,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.normalize_rle.html b/docs/build/rnalysis.filtering.CountFilter.normalize_rle.html
index ef85b5c4..697a66a2 100644
--- a/docs/build/rnalysis.filtering.CountFilter.normalize_rle.html
+++ b/docs/build/rnalysis.filtering.CountFilter.normalize_rle.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.normalize_rle &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.normalize_rle &mdash; RNAlysis 3.9.0 documentation</title>
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       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -122,6 +122,8 @@
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-  <title>rnalysis.filtering.CountFilter.normalize_to_rpkm &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.normalize_to_rpm &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.normalize_to_rpm_htseqcount &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.normalize_to_rpm_htseqcount &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.normalize_to_tpm.html b/docs/build/rnalysis.filtering.CountFilter.normalize_to_tpm.html
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--- a/docs/build/rnalysis.filtering.CountFilter.normalize_to_tpm.html
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-  <title>rnalysis.filtering.CountFilter.normalize_to_tpm &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.normalize_with_scaling_factors.html b/docs/build/rnalysis.filtering.CountFilter.normalize_with_scaling_factors.html
index b6ea3199..9dec404c 100644
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-  <title>rnalysis.filtering.CountFilter.normalize_with_scaling_factors &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.number_filters.html b/docs/build/rnalysis.filtering.CountFilter.number_filters.html
index 6add52f4..f76171a4 100644
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-  <title>rnalysis.filtering.CountFilter.number_filters &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.pairplot.html b/docs/build/rnalysis.filtering.CountFilter.pairplot.html
index f31de0ad..cea2f9af 100644
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.print_features.html">rnalysis.filtering.CountFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
@@ -187,7 +189,7 @@
 <h1>rnalysis.filtering.CountFilter.pca<a class="headerlink" href="#rnalysis-filtering-countfilter-pca" title="Permalink to this heading"></a></h1>
 <dl class="py method">
 <dt class="sig sig-object py" id="rnalysis.filtering.CountFilter.pca">
-<span class="sig-prename descclassname"><span class="pre">CountFilter.</span></span><span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.filtering.CountFilter.pca" title="Permalink to this definition"></a></dt>
+<span class="sig-prename descclassname"><span class="pre">CountFilter.</span></span><span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_grid</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span><a class="headerlink" href="#rnalysis.filtering.CountFilter.pca" title="Permalink to this definition"></a></dt>
 <dd><p>Performs Principal Component Analysis (PCA), visualizing the principal components that explain the most        variance between the different samples. The function will standardize the data prior to PCA, and then plot         the requested number of pairwise PCA projections.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -201,6 +203,7 @@ <h1>rnalysis.filtering.CountFilter.pca<a class="headerlink" href="#rnalysis-filt
 <li><p><strong>label_fontsize</strong> (<em>float</em><em> (</em><em>default=15</em><em>)</em>) – determines the font size of the X and Y axis labels.</p></li>
 <li><p><strong>tick_fontsize</strong> (<em>float</em><em> (</em><em>default=10</em><em>)</em>) – determines the font size of the X and Y tick labels, and the sample name labels. .</p></li>
 <li><p><strong>proportional_axes</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the dimensions of the PCA plots will be proportional         to the percentage of variance explained by each principal component.</p></li>
+<li><p><strong>plot_grid</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will draw a grid on the PCA plot.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Returns</dt>
diff --git a/docs/build/rnalysis.filtering.CountFilter.plot_expression.html b/docs/build/rnalysis.filtering.CountFilter.plot_expression.html
index 85e91d1a..bf48f30b 100644
--- a/docs/build/rnalysis.filtering.CountFilter.plot_expression.html
+++ b/docs/build/rnalysis.filtering.CountFilter.plot_expression.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.plot_expression &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.plot_expression &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -122,6 +122,8 @@
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.print_features.html">rnalysis.filtering.CountFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.print_features.html b/docs/build/rnalysis.filtering.CountFilter.print_features.html
index 8129b6a4..0051fd39 100644
--- a/docs/build/rnalysis.filtering.CountFilter.print_features.html
+++ b/docs/build/rnalysis.filtering.CountFilter.print_features.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.print_features &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.print_features &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -122,6 +122,8 @@
 </ul>
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.save_csv.html b/docs/build/rnalysis.filtering.CountFilter.save_csv.html
index e51a8334..22f772e2 100644
--- a/docs/build/rnalysis.filtering.CountFilter.save_csv.html
+++ b/docs/build/rnalysis.filtering.CountFilter.save_csv.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.save_csv &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.save_csv &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -22,7 +22,7 @@
     <script src="_static/js/theme.js"></script>
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="rnalysis.filtering.CountFilter.scatter_sample_vs_sample" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html" />
+    <link rel="next" title="rnalysis.filtering.CountFilter.save_parquet" href="rnalysis.filtering.CountFilter.save_parquet.html" />
     <link rel="prev" title="rnalysis.filtering.CountFilter.print_features" href="rnalysis.filtering.CountFilter.print_features.html" /> 
 </head>
 
@@ -122,6 +122,8 @@
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.CountFilter.save_csv"><code class="docutils literal notranslate"><span class="pre">CountFilter.save_csv()</span></code></a></li>
 </ul>
 </li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
@@ -203,7 +205,7 @@ <h1>rnalysis.filtering.CountFilter.save_csv<a class="headerlink" href="#rnalysis
           </div>
           <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
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-        <a href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html" class="btn btn-neutral float-right" title="rnalysis.filtering.CountFilter.scatter_sample_vs_sample" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
+        <a href="rnalysis.filtering.CountFilter.save_parquet.html" class="btn btn-neutral float-right" title="rnalysis.filtering.CountFilter.save_parquet" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.save_parquet.html b/docs/build/rnalysis.filtering.CountFilter.save_parquet.html
new file mode 100644
index 00000000..c398c281
--- /dev/null
+++ b/docs/build/rnalysis.filtering.CountFilter.save_parquet.html
@@ -0,0 +1,234 @@
+<!DOCTYPE html>
+<html class="writer-html5" lang="en" >
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+  <title>rnalysis.filtering.CountFilter.save_parquet &mdash; RNAlysis 3.9.0 documentation</title>
+      <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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+              <p class="caption" role="heading"><span class="caption-text">About RNAlysis:</span></p>
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+  <section id="rnalysis-filtering-countfilter-save-parquet">
+<h1>rnalysis.filtering.CountFilter.save_parquet<a class="headerlink" href="#rnalysis-filtering-countfilter-save-parquet" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.CountFilter.save_parquet">
+<span class="sig-prename descclassname"><span class="pre">CountFilter.</span></span><span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.CountFilter.save_parquet" title="Permalink to this definition"></a></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.normalize_to_tpm.html">rnalysis.filtering.CountFilter.normalize_to_tpm</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.pairplot.html">rnalysis.filtering.CountFilter.pairplot</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.pca.html">rnalysis.filtering.CountFilter.pca</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.print_features.html">rnalysis.filtering.CountFilter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.CountFilter.save_table</a><ul>
+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.CountFilter.save_table"><code class="docutils literal notranslate"><span class="pre">CountFilter.save_table()</span></code></a></li>
+</ul>
+</li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_percentile.html">rnalysis.filtering.CountFilter.split_by_percentile</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_principal_components.html">rnalysis.filtering.CountFilter.split_by_principal_components</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_reads.html">rnalysis.filtering.CountFilter.split_by_reads</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_clicom.html">rnalysis.filtering.CountFilter.split_clicom</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_hdbscan.html">rnalysis.filtering.CountFilter.split_hdbscan</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_hierarchical.html">rnalysis.filtering.CountFilter.split_hierarchical</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_kmedoids.html">rnalysis.filtering.CountFilter.split_kmedoids</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.symmetric_difference.html">rnalysis.filtering.CountFilter.symmetric_difference</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.tail.html">rnalysis.filtering.CountFilter.tail</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.text_filters.html">rnalysis.filtering.CountFilter.text_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.transform.html">rnalysis.filtering.CountFilter.transform</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.translate_gene_ids.html">rnalysis.filtering.CountFilter.translate_gene_ids</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.union.html">rnalysis.filtering.CountFilter.union</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.violin_plot.html">rnalysis.filtering.CountFilter.violin_plot</a></li>
+</ul>
+</li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html">rnalysis.filtering.DESeqFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Filter.html">rnalysis.filtering.Filter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.html">rnalysis.filtering.FoldChangeFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Pipeline.html">rnalysis.filtering.Pipeline</a></li>
+</ul>
+</li>
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.enrichment.html">rnalysis.enrichment</a></li>
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.general.html">rnalysis.general</a></li>
+</ul>
+<p class="caption" role="heading"><span class="caption-text">Indices and tables:</span></p>
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+          <li><a href="rnalysis.filtering.CountFilter.html">rnalysis.filtering.CountFilter</a> &raquo;</li>
+      <li>rnalysis.filtering.CountFilter.save_table</li>
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+  <section id="rnalysis-filtering-countfilter-save-table">
+<h1>rnalysis.filtering.CountFilter.save_table<a class="headerlink" href="#rnalysis-filtering-countfilter-save-table" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.CountFilter.save_table">
+<span class="sig-prename descclassname"><span class="pre">CountFilter.</span></span><span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.CountFilter.save_table" title="Permalink to this definition"></a></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
+</section>
+
+
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diff --git a/docs/build/rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html b/docs/build/rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html
index 9fd31c68..1a891aa8 100644
--- a/docs/build/rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html
+++ b/docs/build/rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.scatter_sample_vs_sample &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.scatter_sample_vs_sample &mdash; RNAlysis 3.9.0 documentation</title>
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+    <link rel="prev" title="rnalysis.filtering.CountFilter.save_table" href="rnalysis.filtering.CountFilter.save_table.html" /> 
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@@ -119,6 +119,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.print_features.html">rnalysis.filtering.CountFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.CountFilter.scatter_sample_vs_sample"><code class="docutils literal notranslate"><span class="pre">CountFilter.scatter_sample_vs_sample()</span></code></a></li>
 </ul>
@@ -228,7 +230,7 @@ <h1>rnalysis.filtering.CountFilter.scatter_sample_vs_sample<a class="headerlink"
            </div>
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+        <a href="rnalysis.filtering.CountFilter.save_table.html" class="btn btn-neutral float-left" title="rnalysis.filtering.CountFilter.save_table" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.sort.html b/docs/build/rnalysis.filtering.CountFilter.sort.html
index f9524464..91bd178d 100644
--- a/docs/build/rnalysis.filtering.CountFilter.sort.html
+++ b/docs/build/rnalysis.filtering.CountFilter.sort.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.sort &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.sort &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.print_features.html">rnalysis.filtering.CountFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.CountFilter.sort</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.CountFilter.sort"><code class="docutils literal notranslate"><span class="pre">CountFilter.sort()</span></code></a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.split_by_attribute.html b/docs/build/rnalysis.filtering.CountFilter.split_by_attribute.html
index e2554664..51b55f86 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_by_attribute.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.CountFilter.split_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_by_attribute &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.sort.html">rnalysis.filtering.CountFilter.sort</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_by_percentile.html b/docs/build/rnalysis.filtering.CountFilter.split_by_percentile.html
index 74be1457..bbe6094a 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_by_percentile.html
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-  <title>rnalysis.filtering.CountFilter.split_by_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_by_percentile &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_by_principal_components.html b/docs/build/rnalysis.filtering.CountFilter.split_by_principal_components.html
index 2e8086b7..4b617381 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_by_principal_components.html
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-  <title>rnalysis.filtering.CountFilter.split_by_principal_components &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_by_principal_components &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_by_reads.html b/docs/build/rnalysis.filtering.CountFilter.split_by_reads.html
index 5011530f..c453c83f 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_by_reads.html
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-  <title>rnalysis.filtering.CountFilter.split_by_reads &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_by_reads &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.plot_expression.html">rnalysis.filtering.CountFilter.plot_expression</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_clicom.html b/docs/build/rnalysis.filtering.CountFilter.split_clicom.html
index 0b60a6fd..a1acb8bd 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_clicom.html
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-  <title>rnalysis.filtering.CountFilter.split_clicom &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_clicom &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_hdbscan.html b/docs/build/rnalysis.filtering.CountFilter.split_hdbscan.html
index 43b20f58..dd882df2 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_hdbscan.html
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-  <title>rnalysis.filtering.CountFilter.split_hdbscan &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_hdbscan &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.split_by_attribute.html">rnalysis.filtering.CountFilter.split_by_attribute</a></li>
diff --git a/docs/build/rnalysis.filtering.CountFilter.split_hierarchical.html b/docs/build/rnalysis.filtering.CountFilter.split_hierarchical.html
index 86ef2686..d0829c9f 100644
--- a/docs/build/rnalysis.filtering.CountFilter.split_hierarchical.html
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-  <title>rnalysis.filtering.CountFilter.split_hierarchical &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_hierarchical &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_csv.html">rnalysis.filtering.CountFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_kmeans.html b/docs/build/rnalysis.filtering.CountFilter.split_kmeans.html
index b90747ce..4447a988 100644
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-  <title>rnalysis.filtering.CountFilter.split_kmeans &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_kmeans &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_parquet.html">rnalysis.filtering.CountFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.save_table.html">rnalysis.filtering.CountFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.CountFilter.scatter_sample_vs_sample.html">rnalysis.filtering.CountFilter.scatter_sample_vs_sample</a></li>
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diff --git a/docs/build/rnalysis.filtering.CountFilter.split_kmedoids.html b/docs/build/rnalysis.filtering.CountFilter.split_kmedoids.html
index f858b4f5..633dca39 100644
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-  <title>rnalysis.filtering.CountFilter.split_kmedoids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.CountFilter.split_kmedoids &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -119,6 +119,8 @@
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-  <title>rnalysis.filtering.CountFilter.symmetric_difference &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.tail &mdash; RNAlysis 3.8.0 documentation</title>
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index 3a2d982b..50e5646b 100644
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-  <title>rnalysis.filtering.CountFilter.text_filters &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.transform &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.translate_gene_ids &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.union &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.CountFilter.violin_plot &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.DESeqFilter.biotypes_from_gtf &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.DESeqFilter.biotypes_from_ref_table &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.describe.html b/docs/build/rnalysis.filtering.DESeqFilter.describe.html
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-  <title>rnalysis.filtering.DESeqFilter.drop_columns &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.DESeqFilter.filter_abs_log2_fold_change &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_abs_log2_fold_change &mdash; RNAlysis 3.9.0 documentation</title>
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index 11e36865..634f3b49 100644
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-  <title>rnalysis.filtering.DESeqFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.9.0 documentation</title>
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-  <title>rnalysis.filtering.DESeqFilter.filter_biotype_from_ref_table &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_biotype_from_ref_table &mdash; RNAlysis 3.9.0 documentation</title>
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-  <title>rnalysis.filtering.DESeqFilter.filter_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_by_go_annotations.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_by_go_annotations.html
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-  <title>rnalysis.filtering.DESeqFilter.filter_duplicate_ids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_duplicate_ids &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_fold_change_direction.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_fold_change_direction.html
index 30c4a3b0..6e07cc6b 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.filter_fold_change_direction.html
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-  <title>rnalysis.filtering.DESeqFilter.filter_fold_change_direction &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_fold_change_direction &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_missing_values.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_missing_values.html
index 1c8937b2..ad5c6d64 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.filter_missing_values.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.filter_missing_values.html
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-  <title>rnalysis.filtering.DESeqFilter.filter_missing_values &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_missing_values &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_percentile.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_percentile.html
index e912bf8b..4d5805e7 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.filter_percentile.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.filter_percentile.html
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-  <title>rnalysis.filtering.DESeqFilter.filter_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_percentile &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_significant.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_significant.html
index 82b33b13..8140fd1e 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.filter_significant.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.filter_significant.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.filter_significant &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_significant &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.filter_top_n.html b/docs/build/rnalysis.filtering.DESeqFilter.filter_top_n.html
index a7eb4339..3f07b9d1 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.filter_top_n.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.filter_top_n.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.filter_top_n &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.filter_top_n &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.from_dataframe.html b/docs/build/rnalysis.filtering.DESeqFilter.from_dataframe.html
index ecbd573f..00749268 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.from_dataframe.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.from_dataframe.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.from_dataframe &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.from_dataframe &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.head.html b/docs/build/rnalysis.filtering.DESeqFilter.head.html
index 332e1f27..95e8bdf4 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.head.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.head.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.head &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.head &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.html b/docs/build/rnalysis.filtering.DESeqFilter.html
index 1a341789..ce1d39ac 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
@@ -275,6 +277,12 @@ <h1>rnalysis.filtering.DESeqFilter<a class="headerlink" href="#rnalysis-filterin
 <tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html#rnalysis.filtering.DESeqFilter.save_csv" title="rnalysis.filtering.DESeqFilter.save_csv"><code class="xref py py-obj docutils literal notranslate"><span class="pre">DESeqFilter.save_csv</span></code></a>([alt_filename])</p></td>
 <td><p>Saves the current filtered data to a .csv file.</p></td>
 </tr>
+<tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html#rnalysis.filtering.DESeqFilter.save_parquet" title="rnalysis.filtering.DESeqFilter.save_parquet"><code class="xref py py-obj docutils literal notranslate"><span class="pre">DESeqFilter.save_parquet</span></code></a>([alt_filename])</p></td>
+<td><p>Saves the current filtered data to a .parquet file.</p></td>
+</tr>
+<tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html#rnalysis.filtering.DESeqFilter.save_table" title="rnalysis.filtering.DESeqFilter.save_table"><code class="xref py py-obj docutils literal notranslate"><span class="pre">DESeqFilter.save_table</span></code></a>([suffix, alt_filename])</p></td>
+<td><p>Save the current filtered data table.</p></td>
+</tr>
 <tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html#rnalysis.filtering.DESeqFilter.sort" title="rnalysis.filtering.DESeqFilter.sort"><code class="xref py py-obj docutils literal notranslate"><span class="pre">DESeqFilter.sort</span></code></a>(by[, ascending, ...])</p></td>
 <td><p>Sort the rows by the values of specified column or columns.</p></td>
 </tr>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.intersection.html b/docs/build/rnalysis.filtering.DESeqFilter.intersection.html
index e908b665..651b3fce 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.intersection.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.intersection &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.majority_vote_intersection.html b/docs/build/rnalysis.filtering.DESeqFilter.majority_vote_intersection.html
index 1fa4cff8..a5175c06 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.majority_vote_intersection.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.majority_vote_intersection.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.majority_vote_intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.majority_vote_intersection &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.number_filters.html b/docs/build/rnalysis.filtering.DESeqFilter.number_filters.html
index 764f699f..306a1357 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.number_filters.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.number_filters.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.number_filters &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.number_filters &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -102,6 +102,8 @@
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.print_features.html b/docs/build/rnalysis.filtering.DESeqFilter.print_features.html
index a5902cdf..448ac343 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.print_features.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.print_features.html
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-  <title>rnalysis.filtering.DESeqFilter.print_features &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.print_features &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -102,6 +102,8 @@
 </ul>
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.save_csv.html b/docs/build/rnalysis.filtering.DESeqFilter.save_csv.html
index a89381f4..d8c824d7 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.save_csv.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.save_csv.html
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.save_csv &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.save_csv &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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-    <link rel="next" title="rnalysis.filtering.DESeqFilter.sort" href="rnalysis.filtering.DESeqFilter.sort.html" />
+    <link rel="next" title="rnalysis.filtering.DESeqFilter.save_parquet" href="rnalysis.filtering.DESeqFilter.save_parquet.html" />
     <link rel="prev" title="rnalysis.filtering.DESeqFilter.print_features" href="rnalysis.filtering.DESeqFilter.print_features.html" /> 
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@@ -102,6 +102,8 @@
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.DESeqFilter.save_csv"><code class="docutils literal notranslate"><span class="pre">DESeqFilter.save_csv()</span></code></a></li>
 </ul>
 </li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
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@@ -175,7 +177,7 @@ <h1>rnalysis.filtering.DESeqFilter.save_csv<a class="headerlink" href="#rnalysis
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.save_parquet.html b/docs/build/rnalysis.filtering.DESeqFilter.save_parquet.html
new file mode 100644
index 00000000..9fd07c92
--- /dev/null
+++ b/docs/build/rnalysis.filtering.DESeqFilter.save_parquet.html
@@ -0,0 +1,206 @@
+<!DOCTYPE html>
+<html class="writer-html5" lang="en" >
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+              <p class="caption" role="heading"><span class="caption-text">About RNAlysis:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="readme.html">What is <em>RNAlysis?</em></a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#what-can-i-do-with-rnalysis">What can I do with <em>RNAlysis</em>?</a></li>
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+</ul>
+<p class="caption" role="heading"><span class="caption-text">Starting with RNAlysis:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="installation.html">Installation</a></li>
+<li class="toctree-l1"><a class="reference internal" href="quick_start.html"><em>RNAlysis</em> quick-start video guide</a></li>
+<li class="toctree-l1"><a class="reference internal" href="tutorial.html">A-to-Z tutorial - example analysis</a></li>
+<li class="toctree-l1"><a class="reference internal" href="faq.html">Frequently asked questions</a></li>
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+</ul>
+<p class="caption" role="heading"><span class="caption-text">Modules:</span></p>
+<ul class="current">
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.fastq.html">rnalysis.fastq</a></li>
+<li class="toctree-l1 current"><a class="reference internal" href="rnalysis.filtering.html">rnalysis.filtering</a><ul class="current">
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.CountFilter.html">rnalysis.filtering.CountFilter</a></li>
+<li class="toctree-l2 current"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html">rnalysis.filtering.DESeqFilter</a><ul class="current">
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html#rnalysis.filtering.DESeqFilter"><code class="docutils literal notranslate"><span class="pre">DESeqFilter</span></code></a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.biotypes_from_gtf.html">rnalysis.filtering.DESeqFilter.biotypes_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.biotypes_from_ref_table.html">rnalysis.filtering.DESeqFilter.biotypes_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.describe.html">rnalysis.filtering.DESeqFilter.describe</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.difference.html">rnalysis.filtering.DESeqFilter.difference</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.drop_columns.html">rnalysis.filtering.DESeqFilter.drop_columns</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_abs_log2_fold_change.html">rnalysis.filtering.DESeqFilter.filter_abs_log2_fold_change</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_biotype_from_gtf.html">rnalysis.filtering.DESeqFilter.filter_biotype_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_biotype_from_ref_table.html">rnalysis.filtering.DESeqFilter.filter_biotype_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_by_attribute.html">rnalysis.filtering.DESeqFilter.filter_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_by_go_annotations.html">rnalysis.filtering.DESeqFilter.filter_by_go_annotations</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_by_kegg_annotations.html">rnalysis.filtering.DESeqFilter.filter_by_kegg_annotations</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_by_row_name.html">rnalysis.filtering.DESeqFilter.filter_by_row_name</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_duplicate_ids.html">rnalysis.filtering.DESeqFilter.filter_duplicate_ids</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_fold_change_direction.html">rnalysis.filtering.DESeqFilter.filter_fold_change_direction</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_missing_values.html">rnalysis.filtering.DESeqFilter.filter_missing_values</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_percentile.html">rnalysis.filtering.DESeqFilter.filter_percentile</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_significant.html">rnalysis.filtering.DESeqFilter.filter_significant</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.filter_top_n.html">rnalysis.filtering.DESeqFilter.filter_top_n</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.from_dataframe.html">rnalysis.filtering.DESeqFilter.from_dataframe</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.head.html">rnalysis.filtering.DESeqFilter.head</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.intersection.html">rnalysis.filtering.DESeqFilter.intersection</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.majority_vote_intersection.html">rnalysis.filtering.DESeqFilter.majority_vote_intersection</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.DESeqFilter.save_parquet</a><ul>
+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.DESeqFilter.save_parquet"><code class="docutils literal notranslate"><span class="pre">DESeqFilter.save_parquet()</span></code></a></li>
+</ul>
+</li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_fold_change_direction.html">rnalysis.filtering.DESeqFilter.split_fold_change_direction</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.symmetric_difference.html">rnalysis.filtering.DESeqFilter.symmetric_difference</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.text_filters.html">rnalysis.filtering.DESeqFilter.text_filters</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.union.html">rnalysis.filtering.DESeqFilter.union</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.volcano_plot.html">rnalysis.filtering.DESeqFilter.volcano_plot</a></li>
+</ul>
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+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Filter.html">rnalysis.filtering.Filter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.html">rnalysis.filtering.FoldChangeFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Pipeline.html">rnalysis.filtering.Pipeline</a></li>
+</ul>
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+  <section id="rnalysis-filtering-deseqfilter-save-parquet">
+<h1>rnalysis.filtering.DESeqFilter.save_parquet<a class="headerlink" href="#rnalysis-filtering-deseqfilter-save-parquet" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.DESeqFilter.save_parquet">
+<span class="sig-prename descclassname"><span class="pre">DESeqFilter.</span></span><span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.DESeqFilter.save_parquet" title="Permalink to this definition"></a></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
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+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.CountFilter.html">rnalysis.filtering.CountFilter</a></li>
+<li class="toctree-l2 current"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html">rnalysis.filtering.DESeqFilter</a><ul class="current">
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html#rnalysis.filtering.DESeqFilter"><code class="docutils literal notranslate"><span class="pre">DESeqFilter</span></code></a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
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+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.DESeqFilter.save_table"><code class="docutils literal notranslate"><span class="pre">DESeqFilter.save_table()</span></code></a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.symmetric_difference.html">rnalysis.filtering.DESeqFilter.symmetric_difference</a></li>
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+  <section id="rnalysis-filtering-deseqfilter-save-table">
+<h1>rnalysis.filtering.DESeqFilter.save_table<a class="headerlink" href="#rnalysis-filtering-deseqfilter-save-table" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.DESeqFilter.save_table">
+<span class="sig-prename descclassname"><span class="pre">DESeqFilter.</span></span><span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.DESeqFilter.save_table" title="Permalink to this definition"></a></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
+</section>
+
+
+           </div>
+          </div>
+          <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
+        <a href="rnalysis.filtering.DESeqFilter.save_parquet.html" class="btn btn-neutral float-left" title="rnalysis.filtering.DESeqFilter.save_parquet" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
+        <a href="rnalysis.filtering.DESeqFilter.sort.html" class="btn btn-neutral float-right" title="rnalysis.filtering.DESeqFilter.sort" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
+    </div>
+
+  <hr/>
+
+  <div role="contentinfo">
+    <p>&#169; Copyright 2021, Guy Teichman.</p>
+  </div>
+
+  Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
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+      jQuery(function () {
+          SphinxRtdTheme.Navigation.enable(true);
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+</html>
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diff --git a/docs/build/rnalysis.filtering.DESeqFilter.sort.html b/docs/build/rnalysis.filtering.DESeqFilter.sort.html
index 18721dd8..2e675fe0 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.sort.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.sort.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.sort &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.sort &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -23,7 +23,7 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.filtering.DESeqFilter.split_by_attribute" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html" />
-    <link rel="prev" title="rnalysis.filtering.DESeqFilter.save_csv" href="rnalysis.filtering.DESeqFilter.save_csv.html" /> 
+    <link rel="prev" title="rnalysis.filtering.DESeqFilter.save_table" href="rnalysis.filtering.DESeqFilter.save_table.html" /> 
 </head>
 
 <body class="wy-body-for-nav"> 
@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.DESeqFilter.sort</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.DESeqFilter.sort"><code class="docutils literal notranslate"><span class="pre">DESeqFilter.sort()</span></code></a></li>
 </ul>
@@ -203,7 +205,7 @@ <h1>rnalysis.filtering.DESeqFilter.sort<a class="headerlink" href="#rnalysis-fil
            </div>
           </div>
           <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
-        <a href="rnalysis.filtering.DESeqFilter.save_csv.html" class="btn btn-neutral float-left" title="rnalysis.filtering.DESeqFilter.save_csv" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
+        <a href="rnalysis.filtering.DESeqFilter.save_table.html" class="btn btn-neutral float-left" title="rnalysis.filtering.DESeqFilter.save_table" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
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     </div>
 
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.split_by_attribute.html b/docs/build/rnalysis.filtering.DESeqFilter.split_by_attribute.html
index 63222d37..344d578e 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.split_by_attribute.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.split_by_attribute.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.split_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.split_by_attribute &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.DESeqFilter.split_by_attribute</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.DESeqFilter.split_by_attribute"><code class="docutils literal notranslate"><span class="pre">DESeqFilter.split_by_attribute()</span></code></a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.split_by_percentile.html b/docs/build/rnalysis.filtering.DESeqFilter.split_by_percentile.html
index 0df0d551..33848497 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.split_by_percentile.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.split_by_percentile.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.split_by_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.split_by_percentile &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.DESeqFilter.split_by_percentile</a><ul>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.split_fold_change_direction.html b/docs/build/rnalysis.filtering.DESeqFilter.split_fold_change_direction.html
index 1c570bb6..9c318e84 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.split_fold_change_direction.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.split_fold_change_direction.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.split_fold_change_direction &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.split_fold_change_direction &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.symmetric_difference.html b/docs/build/rnalysis.filtering.DESeqFilter.symmetric_difference.html
index 83020fc3..9cc8de29 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.symmetric_difference.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.symmetric_difference.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.symmetric_difference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.symmetric_difference &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.tail.html b/docs/build/rnalysis.filtering.DESeqFilter.tail.html
index 8aac113d..6ef6010b 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.tail.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.tail.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.tail &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.tail &mdash; RNAlysis 3.9.0 documentation</title>
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       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.text_filters.html b/docs/build/rnalysis.filtering.DESeqFilter.text_filters.html
index 44be6112..003e5669 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.text_filters.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.text_filters.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.text_filters &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.text_filters &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_csv.html">rnalysis.filtering.DESeqFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_parquet.html">rnalysis.filtering.DESeqFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.save_table.html">rnalysis.filtering.DESeqFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.sort.html">rnalysis.filtering.DESeqFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_attribute.html">rnalysis.filtering.DESeqFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.split_by_percentile.html">rnalysis.filtering.DESeqFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.DESeqFilter.transform.html b/docs/build/rnalysis.filtering.DESeqFilter.transform.html
index 96212059..e3e0b952 100644
--- a/docs/build/rnalysis.filtering.DESeqFilter.transform.html
+++ b/docs/build/rnalysis.filtering.DESeqFilter.transform.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.DESeqFilter.transform &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.DESeqFilter.transform &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -99,6 +99,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.number_filters.html">rnalysis.filtering.DESeqFilter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.print_features.html">rnalysis.filtering.DESeqFilter.print_features</a></li>
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-  <title>rnalysis.filtering.Filter.filter_duplicate_ids &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.Filter.filter_missing_values &mdash; RNAlysis 3.8.0 documentation</title>
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-  <title>rnalysis.filtering.Filter.filter_top_n &mdash; RNAlysis 3.8.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.Filter.html b/docs/build/rnalysis.filtering.Filter.html
index 238bdb0c..fa08af88 100644
--- a/docs/build/rnalysis.filtering.Filter.html
+++ b/docs/build/rnalysis.filtering.Filter.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -100,6 +100,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
@@ -264,6 +266,12 @@ <h1>rnalysis.filtering.Filter<a class="headerlink" href="#rnalysis-filtering-fil
 <tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html#rnalysis.filtering.Filter.save_csv" title="rnalysis.filtering.Filter.save_csv"><code class="xref py py-obj docutils literal notranslate"><span class="pre">Filter.save_csv</span></code></a>([alt_filename])</p></td>
 <td><p>Saves the current filtered data to a .csv file.</p></td>
 </tr>
+<tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html#rnalysis.filtering.Filter.save_parquet" title="rnalysis.filtering.Filter.save_parquet"><code class="xref py py-obj docutils literal notranslate"><span class="pre">Filter.save_parquet</span></code></a>([alt_filename])</p></td>
+<td><p>Saves the current filtered data to a .parquet file.</p></td>
+</tr>
+<tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html#rnalysis.filtering.Filter.save_table" title="rnalysis.filtering.Filter.save_table"><code class="xref py py-obj docutils literal notranslate"><span class="pre">Filter.save_table</span></code></a>([suffix, alt_filename])</p></td>
+<td><p>Save the current filtered data table.</p></td>
+</tr>
 <tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.Filter.sort.html#rnalysis.filtering.Filter.sort" title="rnalysis.filtering.Filter.sort"><code class="xref py py-obj docutils literal notranslate"><span class="pre">Filter.sort</span></code></a>(by[, ascending, na_position, ...])</p></td>
 <td><p>Sort the rows by the values of specified column or columns.</p></td>
 </tr>
diff --git a/docs/build/rnalysis.filtering.Filter.intersection.html b/docs/build/rnalysis.filtering.Filter.intersection.html
index 4b0a843d..6df249e7 100644
--- a/docs/build/rnalysis.filtering.Filter.intersection.html
+++ b/docs/build/rnalysis.filtering.Filter.intersection.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.intersection &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -100,6 +100,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.majority_vote_intersection.html b/docs/build/rnalysis.filtering.Filter.majority_vote_intersection.html
index 69a924a1..598f41ee 100644
--- a/docs/build/rnalysis.filtering.Filter.majority_vote_intersection.html
+++ b/docs/build/rnalysis.filtering.Filter.majority_vote_intersection.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.majority_vote_intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.majority_vote_intersection &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -100,6 +100,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.number_filters.html b/docs/build/rnalysis.filtering.Filter.number_filters.html
index b403cd58..7c8237a4 100644
--- a/docs/build/rnalysis.filtering.Filter.number_filters.html
+++ b/docs/build/rnalysis.filtering.Filter.number_filters.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.number_filters &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.number_filters &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -100,6 +100,8 @@
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.print_features.html b/docs/build/rnalysis.filtering.Filter.print_features.html
index a205a8b1..a3f1e5e0 100644
--- a/docs/build/rnalysis.filtering.Filter.print_features.html
+++ b/docs/build/rnalysis.filtering.Filter.print_features.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.print_features &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.print_features &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -100,6 +100,8 @@
 </ul>
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.save_csv.html b/docs/build/rnalysis.filtering.Filter.save_csv.html
index 02d1efb0..ff88f211 100644
--- a/docs/build/rnalysis.filtering.Filter.save_csv.html
+++ b/docs/build/rnalysis.filtering.Filter.save_csv.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.save_csv &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.save_csv &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -22,7 +22,7 @@
     <script src="_static/js/theme.js"></script>
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="rnalysis.filtering.Filter.sort" href="rnalysis.filtering.Filter.sort.html" />
+    <link rel="next" title="rnalysis.filtering.Filter.save_parquet" href="rnalysis.filtering.Filter.save_parquet.html" />
     <link rel="prev" title="rnalysis.filtering.Filter.print_features" href="rnalysis.filtering.Filter.print_features.html" /> 
 </head>
 
@@ -100,6 +100,8 @@
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.Filter.save_csv"><code class="docutils literal notranslate"><span class="pre">Filter.save_csv()</span></code></a></li>
 </ul>
 </li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
@@ -170,7 +172,7 @@ <h1>rnalysis.filtering.Filter.save_csv<a class="headerlink" href="#rnalysis-filt
           </div>
           <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
         <a href="rnalysis.filtering.Filter.print_features.html" class="btn btn-neutral float-left" title="rnalysis.filtering.Filter.print_features" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
-        <a href="rnalysis.filtering.Filter.sort.html" class="btn btn-neutral float-right" title="rnalysis.filtering.Filter.sort" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
+        <a href="rnalysis.filtering.Filter.save_parquet.html" class="btn btn-neutral float-right" title="rnalysis.filtering.Filter.save_parquet" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
     </div>
 
   <hr/>
diff --git a/docs/build/rnalysis.filtering.Filter.save_parquet.html b/docs/build/rnalysis.filtering.Filter.save_parquet.html
new file mode 100644
index 00000000..40cd7803
--- /dev/null
+++ b/docs/build/rnalysis.filtering.Filter.save_parquet.html
@@ -0,0 +1,201 @@
+<!DOCTYPE html>
+<html class="writer-html5" lang="en" >
+<head>
+  <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
+
+  <meta name="viewport" content="width=device-width, initial-scale=1.0" />
+  <title>rnalysis.filtering.Filter.save_parquet &mdash; RNAlysis 3.9.0 documentation</title>
+      <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
+      <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
+    <link rel="shortcut icon" href="_static/favicon.ico"/>
+  <!--[if lt IE 9]>
+    <script src="_static/js/html5shiv.min.js"></script>
+  <![endif]-->
+  
+        <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
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+        <script src="_static/underscore.js"></script>
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+        <script src="_static/copybutton.js"></script>
+    <script src="_static/js/theme.js"></script>
+    <link rel="index" title="Index" href="genindex.html" />
+    <link rel="search" title="Search" href="search.html" />
+    <link rel="next" title="rnalysis.filtering.Filter.save_table" href="rnalysis.filtering.Filter.save_table.html" />
+    <link rel="prev" title="rnalysis.filtering.Filter.save_csv" href="rnalysis.filtering.Filter.save_csv.html" /> 
+</head>
+
+<body class="wy-body-for-nav"> 
+  <div class="wy-grid-for-nav">
+    <nav data-toggle="wy-nav-shift" class="wy-nav-side">
+      <div class="wy-side-scroll">
+        <div class="wy-side-nav-search" >
+            <a href="index.html">
+            <img src="_static/logo.png" class="logo" alt="Logo"/>
+          </a>
+<div role="search">
+  <form id="rtd-search-form" class="wy-form" action="search.html" method="get">
+    <input type="text" name="q" placeholder="Search docs" />
+    <input type="hidden" name="check_keywords" value="yes" />
+    <input type="hidden" name="area" value="default" />
+  </form>
+</div>
+        </div><div class="wy-menu wy-menu-vertical" data-spy="affix" role="navigation" aria-label="Navigation menu">
+              <p class="caption" role="heading"><span class="caption-text">About RNAlysis:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="readme.html">What is <em>RNAlysis?</em></a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#what-can-i-do-with-rnalysis">What can I do with <em>RNAlysis</em>?</a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#how-do-i-install-it">How do I install it?</a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#how-do-i-use-it">How do I use it?</a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#dependencies">Dependencies</a></li>
+<li class="toctree-l1"><a class="reference internal" href="readme.html#credits">Credits</a></li>
+<li class="toctree-l1"><a class="reference external" href="https://github.com/GuyTeichman/RNAlysis">GitHub page</a></li>
+<li class="toctree-l1"><a class="reference internal" href="contributing.html">How can I contribute to <em>RNAlysis</em>?</a></li>
+</ul>
+<p class="caption" role="heading"><span class="caption-text">Starting with RNAlysis:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="installation.html">Installation</a></li>
+<li class="toctree-l1"><a class="reference internal" href="quick_start.html"><em>RNAlysis</em> quick-start video guide</a></li>
+<li class="toctree-l1"><a class="reference internal" href="tutorial.html">A-to-Z tutorial - example analysis</a></li>
+<li class="toctree-l1"><a class="reference internal" href="faq.html">Frequently asked questions</a></li>
+<li class="toctree-l1"><a class="reference internal" href="user_guide_gui.html">User guide - graphical interface</a></li>
+<li class="toctree-l1"><a class="reference internal" href="user_guide.html">User guide - programmatic interface</a></li>
+<li class="toctree-l1"><a class="reference internal" href="glossary.html">Glossary - programmatic interface</a></li>
+</ul>
+<p class="caption" role="heading"><span class="caption-text">Change history:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="history.html">History</a></li>
+</ul>
+<p class="caption" role="heading"><span class="caption-text">Modules:</span></p>
+<ul class="current">
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.fastq.html">rnalysis.fastq</a></li>
+<li class="toctree-l1 current"><a class="reference internal" href="rnalysis.filtering.html">rnalysis.filtering</a><ul class="current">
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.CountFilter.html">rnalysis.filtering.CountFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html">rnalysis.filtering.DESeqFilter</a></li>
+<li class="toctree-l2 current"><a class="reference internal" href="rnalysis.filtering.Filter.html">rnalysis.filtering.Filter</a><ul class="current">
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"><code class="docutils literal notranslate"><span class="pre">Filter</span></code></a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.biotypes_from_gtf.html">rnalysis.filtering.Filter.biotypes_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.biotypes_from_ref_table.html">rnalysis.filtering.Filter.biotypes_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.describe.html">rnalysis.filtering.Filter.describe</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.difference.html">rnalysis.filtering.Filter.difference</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.drop_columns.html">rnalysis.filtering.Filter.drop_columns</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.filter_biotype_from_gtf.html">rnalysis.filtering.Filter.filter_biotype_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.filter_biotype_from_ref_table.html">rnalysis.filtering.Filter.filter_biotype_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.filter_by_attribute.html">rnalysis.filtering.Filter.filter_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.filter_by_go_annotations.html">rnalysis.filtering.Filter.filter_by_go_annotations</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.Filter.save_parquet</a><ul>
+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.Filter.save_parquet"><code class="docutils literal notranslate"><span class="pre">Filter.save_parquet()</span></code></a></li>
+</ul>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.union.html">rnalysis.filtering.Filter.union</a></li>
+</ul>
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+  <section id="rnalysis-filtering-filter-save-parquet">
+<h1>rnalysis.filtering.Filter.save_parquet<a class="headerlink" href="#rnalysis-filtering-filter-save-parquet" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.Filter.save_parquet">
+<span class="sig-prename descclassname"><span class="pre">Filter.</span></span><span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.Filter.save_parquet" title="Permalink to this definition"></a></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
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diff --git a/docs/build/rnalysis.filtering.Filter.save_table.html b/docs/build/rnalysis.filtering.Filter.save_table.html
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter"><code class="docutils literal notranslate"><span class="pre">Filter</span></code></a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.Filter.save_table</a><ul>
+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.Filter.save_table"><code class="docutils literal notranslate"><span class="pre">Filter.save_table()</span></code></a></li>
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+</ul>
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+           <div itemprop="articleBody">
+             
+  <section id="rnalysis-filtering-filter-save-table">
+<h1>rnalysis.filtering.Filter.save_table<a class="headerlink" href="#rnalysis-filtering-filter-save-table" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.Filter.save_table">
+<span class="sig-prename descclassname"><span class="pre">Filter.</span></span><span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.Filter.save_table" title="Permalink to this definition"></a></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
+</section>
+
+
+           </div>
+          </div>
+          <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
+        <a href="rnalysis.filtering.Filter.save_parquet.html" class="btn btn-neutral float-left" title="rnalysis.filtering.Filter.save_parquet" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
+        <a href="rnalysis.filtering.Filter.sort.html" class="btn btn-neutral float-right" title="rnalysis.filtering.Filter.sort" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
+    </div>
+
+  <hr/>
+
+  <div role="contentinfo">
+    <p>&#169; Copyright 2021, Guy Teichman.</p>
+  </div>
+
+  Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
+    <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
+    provided by <a href="https://readthedocs.org">Read the Docs</a>.
+   
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+  </div>
+  <script>
+      jQuery(function () {
+          SphinxRtdTheme.Navigation.enable(true);
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+  </script> 
+
+</body>
+</html>
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diff --git a/docs/build/rnalysis.filtering.Filter.sort.html b/docs/build/rnalysis.filtering.Filter.sort.html
index 244da25a..a6559963 100644
--- a/docs/build/rnalysis.filtering.Filter.sort.html
+++ b/docs/build/rnalysis.filtering.Filter.sort.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.sort &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.sort &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -23,7 +23,7 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.filtering.Filter.split_by_attribute" href="rnalysis.filtering.Filter.split_by_attribute.html" />
-    <link rel="prev" title="rnalysis.filtering.Filter.save_csv" href="rnalysis.filtering.Filter.save_csv.html" /> 
+    <link rel="prev" title="rnalysis.filtering.Filter.save_table" href="rnalysis.filtering.Filter.save_table.html" /> 
 </head>
 
 <body class="wy-body-for-nav"> 
@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.Filter.sort</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.Filter.sort"><code class="docutils literal notranslate"><span class="pre">Filter.sort()</span></code></a></li>
 </ul>
@@ -198,7 +200,7 @@ <h1>rnalysis.filtering.Filter.sort<a class="headerlink" href="#rnalysis-filterin
            </div>
           </div>
           <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
-        <a href="rnalysis.filtering.Filter.save_csv.html" class="btn btn-neutral float-left" title="rnalysis.filtering.Filter.save_csv" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
+        <a href="rnalysis.filtering.Filter.save_table.html" class="btn btn-neutral float-left" title="rnalysis.filtering.Filter.save_table" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
         <a href="rnalysis.filtering.Filter.split_by_attribute.html" class="btn btn-neutral float-right" title="rnalysis.filtering.Filter.split_by_attribute" accesskey="n" rel="next">Next <span class="fa fa-arrow-circle-right" aria-hidden="true"></span></a>
     </div>
 
diff --git a/docs/build/rnalysis.filtering.Filter.split_by_attribute.html b/docs/build/rnalysis.filtering.Filter.split_by_attribute.html
index 5e254ff2..5cadf20f 100644
--- a/docs/build/rnalysis.filtering.Filter.split_by_attribute.html
+++ b/docs/build/rnalysis.filtering.Filter.split_by_attribute.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.split_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.split_by_attribute &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.Filter.split_by_attribute</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.Filter.split_by_attribute"><code class="docutils literal notranslate"><span class="pre">Filter.split_by_attribute()</span></code></a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.split_by_percentile.html b/docs/build/rnalysis.filtering.Filter.split_by_percentile.html
index 65a3ea4d..5d819c52 100644
--- a/docs/build/rnalysis.filtering.Filter.split_by_percentile.html
+++ b/docs/build/rnalysis.filtering.Filter.split_by_percentile.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.split_by_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.split_by_percentile &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.Filter.split_by_percentile</a><ul>
diff --git a/docs/build/rnalysis.filtering.Filter.symmetric_difference.html b/docs/build/rnalysis.filtering.Filter.symmetric_difference.html
index a46fd457..d46c4e9d 100644
--- a/docs/build/rnalysis.filtering.Filter.symmetric_difference.html
+++ b/docs/build/rnalysis.filtering.Filter.symmetric_difference.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.symmetric_difference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.symmetric_difference &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.tail.html b/docs/build/rnalysis.filtering.Filter.tail.html
index f78885c8..47da0aec 100644
--- a/docs/build/rnalysis.filtering.Filter.tail.html
+++ b/docs/build/rnalysis.filtering.Filter.tail.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.tail &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.tail &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.text_filters.html b/docs/build/rnalysis.filtering.Filter.text_filters.html
index 78a4337c..4f63730a 100644
--- a/docs/build/rnalysis.filtering.Filter.text_filters.html
+++ b/docs/build/rnalysis.filtering.Filter.text_filters.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.text_filters &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.text_filters &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.transform.html b/docs/build/rnalysis.filtering.Filter.transform.html
index 91246a66..bd456d59 100644
--- a/docs/build/rnalysis.filtering.Filter.transform.html
+++ b/docs/build/rnalysis.filtering.Filter.transform.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.transform &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.transform &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.translate_gene_ids.html b/docs/build/rnalysis.filtering.Filter.translate_gene_ids.html
index 495bf304..7f09798f 100644
--- a/docs/build/rnalysis.filtering.Filter.translate_gene_ids.html
+++ b/docs/build/rnalysis.filtering.Filter.translate_gene_ids.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.Filter.translate_gene_ids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.translate_gene_ids &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -97,6 +97,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.number_filters.html">rnalysis.filtering.Filter.number_filters</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.print_features.html">rnalysis.filtering.Filter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_parquet.html">rnalysis.filtering.Filter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_table.html">rnalysis.filtering.Filter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.sort.html">rnalysis.filtering.Filter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_attribute.html">rnalysis.filtering.Filter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.split_by_percentile.html">rnalysis.filtering.Filter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.Filter.union.html b/docs/build/rnalysis.filtering.Filter.union.html
index 855db96f..0e5fd974 100644
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-  <title>rnalysis.filtering.Filter.union &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.Filter.union &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.Filter.save_csv.html">rnalysis.filtering.Filter.save_csv</a></li>
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-  <title>rnalysis.filtering.FoldChangeFilter.biotypes_from_gtf &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.biotypes_from_gtf &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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index 7df2f3ea..ba1500dd 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.biotypes_from_ref_table.html
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-  <title>rnalysis.filtering.FoldChangeFilter.biotypes_from_ref_table &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.biotypes_from_ref_table &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
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index 96b1cf1b..5bfe3e5f 100644
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.describe &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.describe &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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index ffef27a0..a9a7c5ee 100644
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-  <title>rnalysis.filtering.FoldChangeFilter.difference &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.difference &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.drop_columns.html b/docs/build/rnalysis.filtering.FoldChangeFilter.drop_columns.html
index cfae7ae0..93795dd6 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.drop_columns.html
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-  <title>rnalysis.filtering.FoldChangeFilter.drop_columns &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.drop_columns &mdash; RNAlysis 3.9.0 documentation</title>
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 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change.html
index a24c551b..0441bf14 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf.html
index 3d6aef39..e378ada4 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_ref_table.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_ref_table.html
index c5494380..6968bc9d 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_biotype_from_ref_table.html
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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index 240d4a37..228bc76b 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations.html
index 683a8c18..fbf02b79 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_row_name.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_row_name.html
index d8b6e144..234a381c 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_by_row_name.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_by_row_name &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_by_row_name &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids.html
index d1db0387..86d5d266 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction.html
index a633c470..678d42df 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction &mdash; RNAlysis 3.9.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_missing_values.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_missing_values.html
index b22614cf..e0b7ddea 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_missing_values.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_missing_values &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_missing_values &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_percentile.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_percentile.html
index 94d88990..fd5953c8 100644
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.filter_percentile &mdash; RNAlysis 3.9.0 documentation</title>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.filter_top_n.html b/docs/build/rnalysis.filtering.FoldChangeFilter.filter_top_n.html
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-  <title>rnalysis.filtering.FoldChangeFilter.filter_top_n &mdash; RNAlysis 3.8.0 documentation</title>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.head.html b/docs/build/rnalysis.filtering.FoldChangeFilter.head.html
index a1d06a0f..13557cb9 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.head.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.head.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.head &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.head &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -104,6 +104,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.html b/docs/build/rnalysis.filtering.FoldChangeFilter.html
index 3f8199cb..853392d3 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -104,6 +104,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
@@ -280,6 +282,12 @@ <h1>rnalysis.filtering.FoldChangeFilter<a class="headerlink" href="#rnalysis-fil
 <tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html#rnalysis.filtering.FoldChangeFilter.save_csv" title="rnalysis.filtering.FoldChangeFilter.save_csv"><code class="xref py py-obj docutils literal notranslate"><span class="pre">FoldChangeFilter.save_csv</span></code></a>([alt_filename])</p></td>
 <td><p>Saves the current filtered data to a .csv file.</p></td>
 </tr>
+<tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html#rnalysis.filtering.FoldChangeFilter.save_parquet" title="rnalysis.filtering.FoldChangeFilter.save_parquet"><code class="xref py py-obj docutils literal notranslate"><span class="pre">FoldChangeFilter.save_parquet</span></code></a>([alt_filename])</p></td>
+<td><p>Saves the current filtered data to a .parquet file.</p></td>
+</tr>
+<tr class="row-odd"><td><p><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html#rnalysis.filtering.FoldChangeFilter.save_table" title="rnalysis.filtering.FoldChangeFilter.save_table"><code class="xref py py-obj docutils literal notranslate"><span class="pre">FoldChangeFilter.save_table</span></code></a>([suffix, ...])</p></td>
+<td><p>Save the current filtered data table.</p></td>
+</tr>
 <tr class="row-even"><td><p><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html#rnalysis.filtering.FoldChangeFilter.sort" title="rnalysis.filtering.FoldChangeFilter.sort"><code class="xref py py-obj docutils literal notranslate"><span class="pre">FoldChangeFilter.sort</span></code></a>(by[, ascending, ...])</p></td>
 <td><p>Sort the rows by the values of specified column or columns.</p></td>
 </tr>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.intersection.html b/docs/build/rnalysis.filtering.FoldChangeFilter.intersection.html
index 3510b6ac..7f04e3a5 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.intersection.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.intersection.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.intersection &mdash; RNAlysis 3.9.0 documentation</title>
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@@ -104,6 +104,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.majority_vote_intersection.html b/docs/build/rnalysis.filtering.FoldChangeFilter.majority_vote_intersection.html
index 7c11e669..661f9ffb 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.majority_vote_intersection.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.majority_vote_intersection.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.majority_vote_intersection &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.majority_vote_intersection &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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@@ -104,6 +104,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.number_filters.html b/docs/build/rnalysis.filtering.FoldChangeFilter.number_filters.html
index 53645ae6..05e216ae 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.number_filters.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.number_filters.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.number_filters &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.number_filters &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -104,6 +104,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.print_features.html b/docs/build/rnalysis.filtering.FoldChangeFilter.print_features.html
index d5d1a3f9..95e8511d 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.print_features.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.print_features.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.print_features &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.print_features &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -104,6 +104,8 @@
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.randomization_test.html b/docs/build/rnalysis.filtering.FoldChangeFilter.randomization_test.html
index f61187e8..b012b18a 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.randomization_test.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.randomization_test.html
@@ -4,7 +4,7 @@
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   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.randomization_test &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.randomization_test &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -104,6 +104,8 @@
 </ul>
 </li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.save_csv.html b/docs/build/rnalysis.filtering.FoldChangeFilter.save_csv.html
index 0173f10f..3fdf59f7 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.save_csv.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.save_csv.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.save_csv &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.save_csv &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -22,7 +22,7 @@
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     <link rel="search" title="Search" href="search.html" />
-    <link rel="next" title="rnalysis.filtering.FoldChangeFilter.sort" href="rnalysis.filtering.FoldChangeFilter.sort.html" />
+    <link rel="next" title="rnalysis.filtering.FoldChangeFilter.save_parquet" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html" />
     <link rel="prev" title="rnalysis.filtering.FoldChangeFilter.randomization_test" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html" /> 
 </head>
 
@@ -104,6 +104,8 @@
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.FoldChangeFilter.save_csv"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter.save_csv()</span></code></a></li>
 </ul>
 </li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
@@ -174,7 +176,7 @@ <h1>rnalysis.filtering.FoldChangeFilter.save_csv<a class="headerlink" href="#rna
           </div>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.save_parquet.html b/docs/build/rnalysis.filtering.FoldChangeFilter.save_parquet.html
new file mode 100644
index 00000000..a195483d
--- /dev/null
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.save_parquet.html
@@ -0,0 +1,205 @@
+<!DOCTYPE html>
+<html class="writer-html5" lang="en" >
+<head>
+  <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
+
+  <meta name="viewport" content="width=device-width, initial-scale=1.0" />
+  <title>rnalysis.filtering.FoldChangeFilter.save_parquet &mdash; RNAlysis 3.9.0 documentation</title>
+      <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
+      <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
+    <link rel="shortcut icon" href="_static/favicon.ico"/>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.html#rnalysis.filtering.FoldChangeFilter"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter</span></code></a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations.html">rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations.html">rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations</a></li>
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+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction.html">rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction</a></li>
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+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.FoldChangeFilter.save_parquet"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter.save_parquet()</span></code></a></li>
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+  <section id="rnalysis-filtering-foldchangefilter-save-parquet">
+<h1>rnalysis.filtering.FoldChangeFilter.save_parquet<a class="headerlink" href="#rnalysis-filtering-foldchangefilter-save-parquet" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.FoldChangeFilter.save_parquet">
+<span class="sig-prename descclassname"><span class="pre">FoldChangeFilter.</span></span><span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.FoldChangeFilter.save_parquet" title="Permalink to this definition"></a></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
+</dd>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.save_table.html b/docs/build/rnalysis.filtering.FoldChangeFilter.save_table.html
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@@ -0,0 +1,208 @@
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+<li class="toctree-l1"><a class="reference internal" href="readme.html#what-can-i-do-with-rnalysis">What can I do with <em>RNAlysis</em>?</a></li>
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+<li class="toctree-l1"><a class="reference internal" href="installation.html">Installation</a></li>
+<li class="toctree-l1"><a class="reference internal" href="quick_start.html"><em>RNAlysis</em> quick-start video guide</a></li>
+<li class="toctree-l1"><a class="reference internal" href="tutorial.html">A-to-Z tutorial - example analysis</a></li>
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+<li class="toctree-l1"><a class="reference internal" href="user_guide_gui.html">User guide - graphical interface</a></li>
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+<ul>
+<li class="toctree-l1"><a class="reference internal" href="history.html">History</a></li>
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+<ul class="current">
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.fastq.html">rnalysis.fastq</a></li>
+<li class="toctree-l1 current"><a class="reference internal" href="rnalysis.filtering.html">rnalysis.filtering</a><ul class="current">
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.CountFilter.html">rnalysis.filtering.CountFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.DESeqFilter.html">rnalysis.filtering.DESeqFilter</a></li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Filter.html">rnalysis.filtering.Filter</a></li>
+<li class="toctree-l2 current"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.html">rnalysis.filtering.FoldChangeFilter</a><ul class="current">
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.html#rnalysis.filtering.FoldChangeFilter"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter</span></code></a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.biotypes_from_gtf.html">rnalysis.filtering.FoldChangeFilter.biotypes_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.biotypes_from_ref_table.html">rnalysis.filtering.FoldChangeFilter.biotypes_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.describe.html">rnalysis.filtering.FoldChangeFilter.describe</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.difference.html">rnalysis.filtering.FoldChangeFilter.difference</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.drop_columns.html">rnalysis.filtering.FoldChangeFilter.drop_columns</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change.html">rnalysis.filtering.FoldChangeFilter.filter_abs_log2_fold_change</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf.html">rnalysis.filtering.FoldChangeFilter.filter_biotype_from_gtf</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_biotype_from_ref_table.html">rnalysis.filtering.FoldChangeFilter.filter_biotype_from_ref_table</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_attribute.html">rnalysis.filtering.FoldChangeFilter.filter_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations.html">rnalysis.filtering.FoldChangeFilter.filter_by_go_annotations</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations.html">rnalysis.filtering.FoldChangeFilter.filter_by_kegg_annotations</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_by_row_name.html">rnalysis.filtering.FoldChangeFilter.filter_by_row_name</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids.html">rnalysis.filtering.FoldChangeFilter.filter_duplicate_ids</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction.html">rnalysis.filtering.FoldChangeFilter.filter_fold_change_direction</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_missing_values.html">rnalysis.filtering.FoldChangeFilter.filter_missing_values</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_percentile.html">rnalysis.filtering.FoldChangeFilter.filter_percentile</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.filter_top_n.html">rnalysis.filtering.FoldChangeFilter.filter_top_n</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.from_dataframe.html">rnalysis.filtering.FoldChangeFilter.from_dataframe</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.head.html">rnalysis.filtering.FoldChangeFilter.head</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.intersection.html">rnalysis.filtering.FoldChangeFilter.intersection</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.majority_vote_intersection.html">rnalysis.filtering.FoldChangeFilter.majority_vote_intersection</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.number_filters.html">rnalysis.filtering.FoldChangeFilter.number_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.FoldChangeFilter.save_table</a><ul>
+<li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.FoldChangeFilter.save_table"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter.save_table()</span></code></a></li>
+</ul>
+</li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_percentile.html">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html">rnalysis.filtering.FoldChangeFilter.split_fold_change_direction</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.symmetric_difference.html">rnalysis.filtering.FoldChangeFilter.symmetric_difference</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.tail.html">rnalysis.filtering.FoldChangeFilter.tail</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.text_filters.html">rnalysis.filtering.FoldChangeFilter.text_filters</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.transform.html">rnalysis.filtering.FoldChangeFilter.transform</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.translate_gene_ids.html">rnalysis.filtering.FoldChangeFilter.translate_gene_ids</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.union.html">rnalysis.filtering.FoldChangeFilter.union</a></li>
+</ul>
+</li>
+<li class="toctree-l2"><a class="reference internal" href="rnalysis.filtering.Pipeline.html">rnalysis.filtering.Pipeline</a></li>
+</ul>
+</li>
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.enrichment.html">rnalysis.enrichment</a></li>
+<li class="toctree-l1"><a class="reference internal" href="rnalysis.general.html">rnalysis.general</a></li>
+</ul>
+<p class="caption" role="heading"><span class="caption-text">Indices and tables:</span></p>
+<ul>
+<li class="toctree-l1"><a class="reference internal" href="genindex.html">Index</a></li>
+<li class="toctree-l1"><a class="reference internal" href="api_reference.html">API Reference</a></li>
+</ul>
+
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+
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+          <li><a href="rnalysis.filtering.FoldChangeFilter.html">rnalysis.filtering.FoldChangeFilter</a> &raquo;</li>
+      <li>rnalysis.filtering.FoldChangeFilter.save_table</li>
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+            <a href="_sources/rnalysis.filtering.FoldChangeFilter.save_table.rst.txt" rel="nofollow"> View page source</a>
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+          <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
+           <div itemprop="articleBody">
+             
+  <section id="rnalysis-filtering-foldchangefilter-save-table">
+<h1>rnalysis.filtering.FoldChangeFilter.save_table<a class="headerlink" href="#rnalysis-filtering-foldchangefilter-save-table" title="Permalink to this heading"></a></h1>
+<dl class="py method">
+<dt class="sig sig-object py" id="rnalysis.filtering.FoldChangeFilter.save_table">
+<span class="sig-prename descclassname"><span class="pre">FoldChangeFilter.</span></span><span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span><a class="headerlink" href="#rnalysis.filtering.FoldChangeFilter.save_table" title="Permalink to this definition"></a></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
+</section>
+
+
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+          </div>
+          <footer><div class="rst-footer-buttons" role="navigation" aria-label="Footer">
+        <a href="rnalysis.filtering.FoldChangeFilter.save_parquet.html" class="btn btn-neutral float-left" title="rnalysis.filtering.FoldChangeFilter.save_parquet" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
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+    <p>&#169; Copyright 2021, Guy Teichman.</p>
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diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.sort.html b/docs/build/rnalysis.filtering.FoldChangeFilter.sort.html
index 51012300..13f53644 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.sort.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.sort.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.sort &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.sort &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -23,7 +23,7 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.filtering.FoldChangeFilter.split_by_attribute" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html" />
-    <link rel="prev" title="rnalysis.filtering.FoldChangeFilter.save_csv" href="rnalysis.filtering.FoldChangeFilter.save_csv.html" /> 
+    <link rel="prev" title="rnalysis.filtering.FoldChangeFilter.save_table" href="rnalysis.filtering.FoldChangeFilter.save_table.html" /> 
 </head>
 
 <body class="wy-body-for-nav"> 
@@ -101,6 +101,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.FoldChangeFilter.sort</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.FoldChangeFilter.sort"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter.sort()</span></code></a></li>
 </ul>
@@ -202,7 +204,7 @@ <h1>rnalysis.filtering.FoldChangeFilter.sort<a class="headerlink" href="#rnalysi
            </div>
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+        <a href="rnalysis.filtering.FoldChangeFilter.save_table.html" class="btn btn-neutral float-left" title="rnalysis.filtering.FoldChangeFilter.save_table" accesskey="p" rel="prev"><span class="fa fa-arrow-circle-left" aria-hidden="true"></span> Previous</a>
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     </div>
 
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_attribute.html b/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_attribute.html
index 47e84ac5..7d122b01 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_attribute.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_attribute.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.split_by_attribute &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.split_by_attribute &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -101,6 +101,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a><ul>
 <li class="toctree-l4"><a class="reference internal" href="#rnalysis.filtering.FoldChangeFilter.split_by_attribute"><code class="docutils literal notranslate"><span class="pre">FoldChangeFilter.split_by_attribute()</span></code></a></li>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_percentile.html b/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_percentile.html
index 757cae6b..092dd24e 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_percentile.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.split_by_percentile.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.split_by_percentile &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.split_by_percentile &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -101,6 +101,8 @@
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.print_features.html">rnalysis.filtering.FoldChangeFilter.print_features</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.randomization_test.html">rnalysis.filtering.FoldChangeFilter.randomization_test</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_csv.html">rnalysis.filtering.FoldChangeFilter.save_csv</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_parquet.html">rnalysis.filtering.FoldChangeFilter.save_parquet</a></li>
+<li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.save_table.html">rnalysis.filtering.FoldChangeFilter.save_table</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.sort.html">rnalysis.filtering.FoldChangeFilter.sort</a></li>
 <li class="toctree-l3"><a class="reference internal" href="rnalysis.filtering.FoldChangeFilter.split_by_attribute.html">rnalysis.filtering.FoldChangeFilter.split_by_attribute</a></li>
 <li class="toctree-l3 current"><a class="current reference internal" href="#">rnalysis.filtering.FoldChangeFilter.split_by_percentile</a><ul>
diff --git a/docs/build/rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html b/docs/build/rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html
index 0e3a5ede..0de27494 100644
--- a/docs/build/rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html
+++ b/docs/build/rnalysis.filtering.FoldChangeFilter.split_fold_change_direction.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.filtering.FoldChangeFilter.split_fold_change_direction &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.filtering.FoldChangeFilter.split_fold_change_direction &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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@@ -101,6 +101,8 @@
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     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-
+   
 
 </footer>
         </div>
@@ -158,7 +158,7 @@ <h1>rnalysis.general.reset_settings_file<a class="headerlink" href="#rnalysis-ge
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script>
+  </script> 
 
 </body>
-</html>
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\ No newline at end of file
diff --git a/docs/build/rnalysis.general.save_to_csv.html b/docs/build/rnalysis.general.save_to_csv.html
index a1cef27b..3d9fce6c 100644
--- a/docs/build/rnalysis.general.save_to_csv.html
+++ b/docs/build/rnalysis.general.save_to_csv.html
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-  <title>rnalysis.general.save_to_csv &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.general.save_to_csv &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
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     <link rel="next" title="rnalysis.general.set_attr_ref_table_path" href="rnalysis.general.set_attr_ref_table_path.html" />
-    <link rel="prev" title="rnalysis.general.reset_settings_file" href="rnalysis.general.reset_settings_file.html" />
+    <link rel="prev" title="rnalysis.general.reset_settings_file" href="rnalysis.general.reset_settings_file.html" /> 
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@@ -119,7 +119,7 @@
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           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-
+             
   <section id="rnalysis-general-save-to-csv">
 <h1>rnalysis.general.save_to_csv<a class="headerlink" href="#rnalysis-general-save-to-csv" title="Permalink to this heading"></a></h1>
 <dl class="py function">
@@ -151,7 +151,7 @@ <h1>rnalysis.general.save_to_csv<a class="headerlink" href="#rnalysis-general-sa
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
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+   
 
 </footer>
         </div>
@@ -162,7 +162,7 @@ <h1>rnalysis.general.save_to_csv<a class="headerlink" href="#rnalysis-general-sa
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script>
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+</html>
\ No newline at end of file
diff --git a/docs/build/rnalysis.general.set_attr_ref_table_path.html b/docs/build/rnalysis.general.set_attr_ref_table_path.html
index 2f077536..4bece441 100644
--- a/docs/build/rnalysis.general.set_attr_ref_table_path.html
+++ b/docs/build/rnalysis.general.set_attr_ref_table_path.html
@@ -4,14 +4,14 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.general.set_attr_ref_table_path &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.general.set_attr_ref_table_path &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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         <script src="_static/jquery.js"></script>
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@@ -23,10 +23,10 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="rnalysis.general.set_biotype_ref_table_path" href="rnalysis.general.set_biotype_ref_table_path.html" />
-    <link rel="prev" title="rnalysis.general.save_to_csv" href="rnalysis.general.save_to_csv.html" />
+    <link rel="prev" title="rnalysis.general.save_to_csv" href="rnalysis.general.save_to_csv.html" /> 
 </head>
 
-<body class="wy-body-for-nav">
+<body class="wy-body-for-nav"> 
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -119,7 +119,7 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-
+             
   <section id="rnalysis-general-set-attr-ref-table-path">
 <h1>rnalysis.general.set_attr_ref_table_path<a class="headerlink" href="#rnalysis-general-set-attr-ref-table-path" title="Permalink to this heading"></a></h1>
 <dl class="py function">
@@ -159,7 +159,7 @@ <h1>rnalysis.general.set_attr_ref_table_path<a class="headerlink" href="#rnalysi
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-
+   
 
 </footer>
         </div>
@@ -170,7 +170,7 @@ <h1>rnalysis.general.set_attr_ref_table_path<a class="headerlink" href="#rnalysi
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script>
+  </script> 
 
 </body>
-</html>
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\ No newline at end of file
diff --git a/docs/build/rnalysis.general.set_biotype_ref_table_path.html b/docs/build/rnalysis.general.set_biotype_ref_table_path.html
index 8633e9c7..60cebe62 100644
--- a/docs/build/rnalysis.general.set_biotype_ref_table_path.html
+++ b/docs/build/rnalysis.general.set_biotype_ref_table_path.html
@@ -4,14 +4,14 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis.general.set_biotype_ref_table_path &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis.general.set_biotype_ref_table_path &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
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-
+  
         <script data-url_root="./" id="documentation_options" src="_static/documentation_options.js"></script>
         <script src="_static/jquery.js"></script>
         <script src="_static/underscore.js"></script>
@@ -23,10 +23,10 @@
     <link rel="index" title="Index" href="genindex.html" />
     <link rel="search" title="Search" href="search.html" />
     <link rel="next" title="Index" href="genindex.html" />
-    <link rel="prev" title="rnalysis.general.set_attr_ref_table_path" href="rnalysis.general.set_attr_ref_table_path.html" />
+    <link rel="prev" title="rnalysis.general.set_attr_ref_table_path" href="rnalysis.general.set_attr_ref_table_path.html" /> 
 </head>
 
-<body class="wy-body-for-nav">
+<body class="wy-body-for-nav"> 
   <div class="wy-grid-for-nav">
     <nav data-toggle="wy-nav-shift" class="wy-nav-side">
       <div class="wy-side-scroll">
@@ -119,7 +119,7 @@
 </div>
           <div role="main" class="document" itemscope="itemscope" itemtype="http://schema.org/Article">
            <div itemprop="articleBody">
-
+             
   <section id="rnalysis-general-set-biotype-ref-table-path">
 <h1>rnalysis.general.set_biotype_ref_table_path<a class="headerlink" href="#rnalysis-general-set-biotype-ref-table-path" title="Permalink to this heading"></a></h1>
 <dl class="py function">
@@ -159,7 +159,7 @@ <h1>rnalysis.general.set_biotype_ref_table_path<a class="headerlink" href="#rnal
   Built with <a href="https://www.sphinx-doc.org/">Sphinx</a> using a
     <a href="https://github.com/readthedocs/sphinx_rtd_theme">theme</a>
     provided by <a href="https://readthedocs.org">Read the Docs</a>.
-
+   
 
 </footer>
         </div>
@@ -170,7 +170,7 @@ <h1>rnalysis.general.set_biotype_ref_table_path<a class="headerlink" href="#rnal
       jQuery(function () {
           SphinxRtdTheme.Navigation.enable(true);
       });
-  </script>
+  </script> 
 
 </body>
-</html>
+</html>
\ No newline at end of file
diff --git a/docs/build/rnalysis.html b/docs/build/rnalysis.html
index a8d497ea..07c95a05 100644
--- a/docs/build/rnalysis.html
+++ b/docs/build/rnalysis.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>rnalysis package &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>rnalysis package &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
@@ -1419,7 +1419,7 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">pca</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">samples</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">GroupedColumns</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_components</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">3</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">power_transform</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">labels</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">proportional_axes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_grid</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">PCA</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Performs Principal Component Analysis (PCA), visualizing the principal components that explain the most        variance between the different samples. The function will standardize the data prior to PCA, and then plot         the requested number of pairwise PCA projections.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -1433,6 +1433,7 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 <li><p><strong>label_fontsize</strong> (<em>float</em><em> (</em><em>default=15</em><em>)</em>) – determines the font size of the X and Y axis labels.</p></li>
 <li><p><strong>tick_fontsize</strong> (<em>float</em><em> (</em><em>default=10</em><em>)</em>) – determines the font size of the X and Y tick labels, and the sample name labels. .</p></li>
 <li><p><strong>proportional_axes</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the dimensions of the PCA plots will be proportional         to the percentage of variance explained by each principal component.</p></li>
+<li><p><strong>plot_grid</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will draw a grid on the PCA plot.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Returns</dt>
@@ -1523,6 +1524,31 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dl>
 </dd></dl>
 
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
+</dd>
+</dl>
+</dd></dl>
+
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
 <dl class="py method">
 <dt class="sig sig-object py">
 <span class="sig-name descname"><span class="pre">scatter_sample_vs_sample</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">sample1</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">sample2</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">ColumnNames</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">xlabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">20</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">label_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">16</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">tick_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">12</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">annotation_fontsize</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Sequence</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">point_color</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Color</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'#6d7178'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">highlight_color</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Color</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'#00aaff'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">opacity</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.65</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">point_size</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">float</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">interactive</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_cursor</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
@@ -3157,6 +3183,31 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dl>
 </dd></dl>
 
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
+</dd>
+</dl>
+</dd></dl>
+
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
 <dl class="py property">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">property</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">shape</span></span><em class="property"><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></em></dt>
@@ -4311,6 +4362,31 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dl>
 </dd></dl>
 
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
+</dd>
+</dl>
+</dd></dl>
+
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
 <dl class="py property">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">property</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">shape</span></span><em class="property"><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></em></dt>
@@ -5503,6 +5579,31 @@ <h2>rnalysis.filtering module<a class="headerlink" href="#rnalysis-filtering-mod
 </dl>
 </dd></dl>
 
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_parquet</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Saves the current filtered data to a .parquet file.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p>
+</dd>
+</dl>
+</dd></dl>
+
+<dl class="py method">
+<dt class="sig sig-object py">
+<span class="sig-name descname"><span class="pre">save_table</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">suffix</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'.csv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.tsv'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'.parquet'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'.csv'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alt_filename</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em><span class="sig-paren">)</span></dt>
+<dd><p>Save the current filtered data table.</p>
+<dl class="field-list simple">
+<dt class="field-odd">Parameters</dt>
+<dd class="field-odd"><ul class="simple">
+<li><p><strong>suffix</strong> (<em>'.csv'</em><em>, </em><em>'.tsv'</em><em>, or </em><em>'.parquet'</em><em> (</em><em>default='.csv'</em><em>)</em>) – the file suffix</p></li>
+<li><p><strong>alt_filename</strong> (<em>str</em><em>, </em><em>pathlib.Path</em><em>, or </em><em>None</em><em> (</em><em>default</em><em>)</em>) – If None, file name will be generated automatically         according to the filtering methods used.         If it’s a string, it will be used as the name of the saved file. Example input: ‘myfilename’</p></li>
+</ul>
+</dd>
+</dl>
+</dd></dl>
+
 <dl class="py property">
 <dt class="sig sig-object py">
 <em class="property"><span class="pre">property</span><span class="w"> </span></em><span class="sig-name descname"><span class="pre">shape</span></span><em class="property"><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></em></dt>
@@ -6129,7 +6230,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Gene Ontology (GO) terms against a background set.         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6174,6 +6275,10 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 :param ontology_graph_format: if ontology_graph_format is not ‘none’, the ontology graph will additonally be         generated in the specified file format.
 :type plot_horizontal: bool (default=True)
 :param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
+:param show_expected: if True, the observed/expected values will be shown on the plot.
+:type show_expected: bool (default=False)
+:param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.
+:type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
 :type random_seed: non-negative integer (default=None)
 :type random_seed: if using a randomization test, determine the random seed used to initialize         the pseudorandom generator for the randomization test.         By default it is picked at random, but you can set it to a particular integer to get consistents results         over multiple runs. If not using a randomization test, this parameter will not affect the analysis.
 :param randomization_reps: if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.
@@ -6233,7 +6338,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways against a background set.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6251,6 +6356,8 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
 <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
@@ -6417,7 +6524,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">user_defined_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">statistical_test</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'fisher'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'hypergeometric'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'randomization'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'fisher'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">background_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Set</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.filtering.Filter.html#rnalysis.filtering.Filter" title="rnalysis.filtering.Filter"><span class="pre">Filter</span></a><span class="p"><span class="pre">,</span></span><span class="w"> </span><a class="reference internal" href="rnalysis.enrichment.FeatureSet.html#rnalysis.enrichment.FeatureSet" title="rnalysis.enrichment.FeatureSet"><span class="pre">FeatureSet</span></a><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">biotype_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">randomization_reps</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">PositiveInt</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">10000</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">random_seed</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Optional</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Calculates enrichment and depletion of the FeatureSet for user-defined attributes against a background set.        The attributes are drawn from an Attribute Reference Table.         The background set is determined by either the input variable ‘background_genes’,         or by the input variable ‘biotype’ and a Biotype Reference Table.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment score = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6435,6 +6542,8 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em><em> (</em><em>default=None</em><em>)</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default), fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot. Otherwise, results         will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>randomization_reps</strong> (<em>int larger than 0</em><em> (</em><em>default=10000</em><em>)</em>) – if using a randomization test, determine how many randomization repititions to run.         Otherwise, this parameter will not affect the analysis.</p></li>
 <li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
 </ul>
@@ -6475,7 +6584,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span></dt>
+<span class="sig-name descname"><span class="pre">single_set_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">attributes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">List</span><span class="p"><span class="pre">[</span></span><span class="pre">int</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">attr_ref_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'predefined'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'predefined'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for user-defined attributes         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The attributes are drawn from an Attribute Reference Table.         P-values are calculated using using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6515,7 +6624,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">single_set_go_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">propagate_annotations</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'classic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'elim'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'weight'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'all.m'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'no'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'elim'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">aspects</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'biological_process'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'cellular_component'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'molecular_function'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_evidence_types</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'experimental'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'phylogenetic'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'computational'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'author'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'curator'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'electronic'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_databases</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">()</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'any'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'any'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">excluded_qualifiers</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Iterable</span><span class="p"><span class="pre">[</span></span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'not'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'contributes_to'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'colocalizes_with'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'not'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_ontology_graph</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ontology_graph_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Gene Ontology (GO) terms         WITHOUT a background set, using the generalized Minimum Hypergeometric Test (XL-mHG, developed by          <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         The GO terms and annotations are drawn via the GO Solr search engine GOlr,         using the search terms defined by the user.         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6552,6 +6661,10 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 :param return_fig: if True, returns a matplotlib Figure object in addition to the results DataFrame.
 :type plot_horizontal: bool (default=True)
 :param plot_horizontal: if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.
+:param show_expected: if True, the observed/expected values will be shown on the plot.
+:type show_expected: bool (default=False)
+:param plot_style: style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.
+:type plot_style: ‘bar’ or ‘lollipop’ (default=’bar’)
 :type plot_ontology_graph: bool (default=True)
 :param plot_ontology_graph: if True, will generate an ontology graph depicting the         significant GO terms and their parent nodes.
 :type ontology_graph_format: ‘pdf’, ‘png’, ‘svg’, or None (default=None)
@@ -6582,7 +6695,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py method">
 <dt class="sig sig-object py">
-<span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
+<span class="sig-name descname"><span class="pre">single_set_kegg_enrichment</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">organism</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">int</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'Arabodopsis</span> <span class="pre">thaliana'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Caenorhabditis</span> <span class="pre">elegans'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Danio</span> <span class="pre">rerio'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Drosophila</span> <span class="pre">melanogaster'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Escherichia</span> <span class="pre">coli'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Homo</span> <span class="pre">sapiens'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Mus</span> <span class="pre">musculus'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Saccharomyces</span> <span class="pre">cerevisiae'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Schizosaccharomyces</span> <span class="pre">pombe'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gene_id_type</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'UniProtKB</span> <span class="pre">AC/ID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniParc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef50'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef90'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniRef100'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Gene</span> <span class="pre">Name'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CRC64'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Genomes</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Ensembl</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneID'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'KEGG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PATRIC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UCSC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WBParaSite</span> <span class="pre">Transcript/Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ArachnoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Araport'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ConoServer'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'dictyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EchoBASE'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'euHCVdb'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'FlyBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneCards'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneReviews'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'LegioList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Leproma'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MaizeGDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MGI'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'MIM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'neXtProt'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OpenTargets'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Orphanet'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PharmGKB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PomBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PseudoCAP'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'SGD'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TubercuList'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VEuPathDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'VGNC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'WormBase</span> <span class="pre">Transcript'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Xenbase'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ZFIN'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'eggNOG'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneTree'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'HOGENOM'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OMA'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'OrthoDB'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'TreeFam'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CCDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'EMBL/GenBank/DDBJ</span> <span class="pre">CDS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GI</span> <span class="pre">number'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PIR'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Nucleotide'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'RefSeq</span> <span class="pre">Protein'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ChiTaRS'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GeneWiki'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'GenomeRNAi'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PHI-base'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CollecTF'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'BioCyc'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'PlantReactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'Reactome'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'UniPathway'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'CPTAC'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'ProteomicsDB'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">exclude_unannotated_genes</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_nonsignificant</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">save_csv</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">fname</span></span><span class="o"><span class="pre">=</span></span><span class="default_value"><span class="pre">None</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">return_fig</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_pathway_graphs</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">pathway_graphs_format</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'pdf'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'png'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'svg'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'none'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'none'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">parallel_backend</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'multiprocessing'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'loky'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'threading'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'sequential'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'loky'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">gui_mode</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Tuple</span><span class="p"><span class="pre">[</span></span><span class="pre">DataFrame</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Figure</span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span></span></dt>
 <dd><p>Calculates enrichment and depletion of the sorted RankedSet for Kyoto Encyclopedia of Genes and Genomes (KEGG)         curated pathways WITHOUT a background set, using the generalized Minimum Hypergeometric Test         (XL-mHG, developed by <a class="reference external" href="https://dx.doi.org/10.1371/journal.pcbi.0030039/">Prof. Zohar Yakhini and colleagues</a>         and generalized by         <a class="reference external" href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143196/">Florian Wagner</a>).         P-values are calculated using the generalized Minimum Hypergeometric Test.         P-values are corrected for multiple comparisons using the Benjamini–Hochberg step-up procedure         (original FDR method). In plots, for the clarity of display, complete depletion (linear enrichment = 0)         appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6596,6 +6709,8 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>fname</strong> (<em>str</em><em> or </em><em>pathlib.Path</em>) – The full path and name of the file to which to save the results. For example:         ‘C:/dir/file’. No ‘.csv’ suffix is required. If None (default),         fname will be requested in a manual prompt.</p></li>
 <li><p><strong>return_fig</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, returns a matplotlib Figure object in addition to the results DataFrame.</p></li>
 <li><p><strong>plot_horizontal</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, results will be plotted with a horizontal bar plot.         Otherwise, results will be plotted with a vertical plot.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot         in which the lollipop size indicates the size of the observed gene set.</p></li>
 <li><p><strong>plot_pathway_graphs</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, will generate pathway graphs depicting the significant KEGG pathways.</p></li>
 <li><p><strong>pathway_graphs_format</strong> (<em>'pdf'</em><em>, </em><em>'png'</em><em>, </em><em>'svg'</em><em>, or </em><em>None</em><em> (</em><em>default=None</em><em>)</em>) – if pathway_graphs_format is not ‘none’, the pathway graphs will additonally be         generated in the specified file format.</p></li>
 <li><p><strong>parallel_backend</strong> (<em>Literal</em><em>[</em><em>PARALLEL_BACKENDS</em><em>] </em><em>(</em><em>default='loky'</em><em>)</em>) – Determines the babckend used to run the analysis.         if parallel_backend not ‘sequential’, will calculate the statistical tests using parallel processing.         In most cases parallel processing will lead to shorter computation time, but does not affect the results of         the analysis otherwise.</p></li>
@@ -6632,7 +6747,7 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 
 <dl class="py function">
 <dt class="sig sig-object py">
-<span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
+<span class="sig-prename descclassname"><span class="pre">rnalysis.enrichment.</span></span><span class="sig-name descname"><span class="pre">enrichment_bar_plot</span></span><span class="sig-paren">(</span><em class="sig-param"><span class="n"><span class="pre">results_table_path</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Path</span><span class="p"><span class="pre">]</span></span></span></em>, <em class="sig-param"><span class="n"><span class="pre">alpha</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Fraction</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">0.05</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">enrichment_score_column</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'log2_fold_enrichment'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'log2_enrichment_score'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'log2_fold_enrichment'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">n_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">PositiveInt</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'all'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'all'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">title</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">str</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'Enrichment</span> <span class="pre">results'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">center_bars</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_horizontal</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">True</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylabel</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">str</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'$\\log_2$(Enrichment</span> <span class="pre">Score)'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'$\\log_2$(Fold</span> <span class="pre">Enrichment)'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">ylim</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Union</span><span class="p"><span class="pre">[</span></span><span class="pre">float</span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'auto'</span></span><span class="p"><span class="pre">]</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'auto'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">plot_style</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">Literal</span><span class="p"><span class="pre">[</span></span><span class="s"><span class="pre">'bar'</span></span><span class="p"><span class="pre">,</span></span><span class="w"> </span><span class="s"><span class="pre">'lollipop'</span></span><span class="p"><span class="pre">]</span></span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">'bar'</span></span></em>, <em class="sig-param"><span class="n"><span class="pre">show_expected</span></span><span class="p"><span class="pre">:</span></span><span class="w"> </span><span class="n"><span class="pre">bool</span></span><span class="w"> </span><span class="o"><span class="pre">=</span></span><span class="w"> </span><span class="default_value"><span class="pre">False</span></span></em><span class="sig-paren">)</span> <span class="sig-return"><span class="sig-return-icon">&#x2192;</span> <span class="sig-return-typehint"><span class="pre">Figure</span></span></span></dt>
 <dd><p>Generate an enrichment bar-plot based on an enrichment results table.     For the clarity of display, complete depletion (linear enrichment = 0)     appears with the smallest value in the scale.</p>
 <dl class="field-list simple">
 <dt class="field-odd">Parameters</dt>
@@ -6646,6 +6761,8 @@ <h2>rnalysis.enrichment module<a class="headerlink" href="#rnalysis-enrichment-m
 <li><p><strong>ylabel</strong> (<em>str</em><em> (</em><em>default=r&quot;$log_2$</em><em>(</em><em>Fold Enrichment</em><em>)</em><em>&quot;</em><em>)</em>) – plot y-axis label.</p></li>
 <li><p><strong>center_bars</strong> (<em>bool</em><em> (</em><em>default=True</em><em>)</em>) – if True, center the bars around Y=0. Otherwise, ylim is determined by min/max values.</p></li>
 <li><p><strong>ylim</strong> (<em>float</em><em> or </em><em>'auto'</em><em> (</em><em>default='auto'</em><em>)</em>) – set the Y-axis limits. If <cite>ylim`=’auto’, determines the axis limits automatically based on the data.     If `ylim</cite> is a number, set the Y-axis limits to [-ylim, ylim].</p></li>
+<li><p><strong>plot_style</strong> (<em>'bar'</em><em> or </em><em>'lollipop'</em><em> (</em><em>default='bar'</em><em>)</em>) – style for the plot. Either ‘bar’ for a bar plot or ‘lollipop’ for a lollipop plot     in which the lollipop size indicates the size of the observed gene set.</p></li>
+<li><p><strong>show_expected</strong> (<em>bool</em><em> (</em><em>default=False</em><em>)</em>) – if True, the observed/expected values will be shown on the plot.</p></li>
 </ul>
 </dd>
 <dt class="field-even">Returns</dt>
diff --git a/docs/build/search.html b/docs/build/search.html
index 8d213953..3ac9cda6 100644
--- a/docs/build/search.html
+++ b/docs/build/search.html
@@ -3,7 +3,7 @@
 <head>
   <meta charset="utf-8" />
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>Search &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>Search &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
diff --git a/docs/build/searchindex.js b/docs/build/searchindex.js
index 8af42710..70301a66 100644
--- a/docs/build/searchindex.js
+++ b/docs/build/searchindex.js
@@ -1 +1 @@
-Search.setIndex({"docnames": ["api_reference", "faq", "history", "index", "installation", "quick_start", "readme", "rnalysis", "rnalysis.enrichment", "rnalysis.enrichment.FeatureSet", "rnalysis.enrichment.FeatureSet.add", "rnalysis.enrichment.FeatureSet.biotypes", "rnalysis.enrichment.FeatureSet.biotypes_from_ref_table", "rnalysis.enrichment.FeatureSet.change_set_name", "rnalysis.enrichment.FeatureSet.clear", "rnalysis.enrichment.FeatureSet.copy", "rnalysis.enrichment.FeatureSet.difference", "rnalysis.enrichment.FeatureSet.difference_update", "rnalysis.enrichment.FeatureSet.discard", "rnalysis.enrichment.FeatureSet.filter_by_attribute", "rnalysis.enrichment.FeatureSet.filter_by_go_annotations", "rnalysis.enrichment.FeatureSet.filter_by_kegg_annotations", "rnalysis.enrichment.FeatureSet.go_enrichment", "rnalysis.enrichment.FeatureSet.intersection", "rnalysis.enrichment.FeatureSet.intersection_update", "rnalysis.enrichment.FeatureSet.isdisjoint", "rnalysis.enrichment.FeatureSet.issubset", "rnalysis.enrichment.FeatureSet.issuperset", "rnalysis.enrichment.FeatureSet.kegg_enrichment", "rnalysis.enrichment.FeatureSet.non_categorical_enrichment", "rnalysis.enrichment.FeatureSet.pop", "rnalysis.enrichment.FeatureSet.remove", "rnalysis.enrichment.FeatureSet.save_txt", "rnalysis.enrichment.FeatureSet.symmetric_difference", "rnalysis.enrichment.FeatureSet.symmetric_difference_update", "rnalysis.enrichment.FeatureSet.translate_gene_ids", "rnalysis.enrichment.FeatureSet.union", "rnalysis.enrichment.FeatureSet.update", "rnalysis.enrichment.FeatureSet.user_defined_enrichment", "rnalysis.enrichment.RankedSet", "rnalysis.enrichment.RankedSet.add", "rnalysis.enrichment.RankedSet.biotypes", "rnalysis.enrichment.RankedSet.biotypes_from_ref_table", "rnalysis.enrichment.RankedSet.change_set_name", "rnalysis.enrichment.RankedSet.clear", "rnalysis.enrichment.RankedSet.copy", "rnalysis.enrichment.RankedSet.difference", "rnalysis.enrichment.RankedSet.difference_update", "rnalysis.enrichment.RankedSet.discard", "rnalysis.enrichment.RankedSet.filter_by_attribute", "rnalysis.enrichment.RankedSet.filter_by_go_annotations", "rnalysis.enrichment.RankedSet.filter_by_kegg_annotations", "rnalysis.enrichment.RankedSet.go_enrichment", "rnalysis.enrichment.RankedSet.intersection", "rnalysis.enrichment.RankedSet.intersection_update", "rnalysis.enrichment.RankedSet.isdisjoint", "rnalysis.enrichment.RankedSet.issubset", "rnalysis.enrichment.RankedSet.issuperset", "rnalysis.enrichment.RankedSet.kegg_enrichment", "rnalysis.enrichment.RankedSet.non_categorical_enrichment", "rnalysis.enrichment.RankedSet.pop", "rnalysis.enrichment.RankedSet.remove", "rnalysis.enrichment.RankedSet.save_txt", "rnalysis.enrichment.RankedSet.single_set_enrichment", "rnalysis.enrichment.RankedSet.single_set_go_enrichment", "rnalysis.enrichment.RankedSet.single_set_kegg_enrichment", "rnalysis.enrichment.RankedSet.symmetric_difference", 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258, 268, 274, 278], "merg": [0, 7, 98, 156, 157, 278, 279], "csv": [0, 1, 2, 7, 8, 9, 12, 22, 28, 29, 38, 39, 42, 52, 58, 59, 63, 64, 65, 71, 96, 97, 101, 102, 105, 108, 109, 110, 111, 115, 116, 120, 122, 123, 124, 125, 126, 128, 129, 130, 131, 133, 134, 135, 136, 137, 139, 140, 142, 143, 147, 148, 150, 151, 152, 154, 160, 161, 162, 163, 165, 167, 169, 170, 171, 173, 175, 176, 181, 182, 183, 184, 185, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 202, 204, 206, 207, 208, 211, 212, 217, 218, 219, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 235, 236, 238, 239, 240, 242, 244, 245, 250, 253, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 266, 267, 268, 271, 274, 278], "transcript": [0, 2, 4, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 93, 94, 96, 97, 104, 114, 117, 118, 138, 141, 164, 168, 174, 177, 178, 201, 205, 210, 213, 214, 234, 237, 243, 246, 247, 270, 278], "estim": [0, 2, 6, 7, 96, 97, 157, 158, 159, 278, 279], "tpm": [0, 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147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00014997": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00043987": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00043988": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00043989": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00043990": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00044022": [0, 7, 109, 147, 160, 165, 171, 191, 197, 202, 208, 225, 230, 235, 240, 259, 266, 271], "wbgene00044951": [0, 7, 109, 147, 150, 160, 165, 171, 191, 193, 197, 202, 208, 225, 227, 230, 235, 240, 259, 262, 266, 271, 279], "wbgene00077502": [0, 7, 109, 147, 150, 160, 165, 171, 191, 193, 197, 202, 208, 225, 227, 230, 235, 240, 259, 262, 266, 271, 279], "wbgene00077503": [0, 7, 109, 147, 150, 160, 165, 171, 191, 193, 197, 202, 208, 225, 227, 230, 235, 240, 259, 262, 266, 271, 279], "wbgene00077504": [0, 7, 109, 147, 150, 160, 165, 171, 191, 193, 197, 202, 208, 225, 227, 230, 235, 240, 259, 262, 266, 271, 279], "leav": [0, 7, 109, 115, 116, 120, 122, 123, 124, 125, 131, 143, 151, 152, 154, 155, 156, 157, 158, 159, 162, 171, 173, 175, 176, 181, 182, 183, 184, 185, 188, 190, 194, 195, 196, 199, 208, 211, 212, 217, 218, 219, 222, 224, 228, 229, 232, 240, 242, 244, 245, 250, 253, 256, 258, 260, 263, 265, 268, 274, 278, 279], "differential_expression_deseq2": [0, 2, 7], "design_matrix": [0, 7, 110, 111], "comparison": [0, 7, 22, 28, 29, 38, 52, 58, 59, 63, 64, 65, 71, 110, 111, 260, 278, 279], "iter": [0, 7, 20, 22, 29, 38, 50, 52, 59, 63, 64, 71, 75, 110, 111, 117, 128, 129, 149, 158, 159, 177, 213, 246], "algorithm": [0, 7, 110, 155, 156, 157, 158, 159, 278, 279], "unnorm": [0, 7, 110], "raw": [0, 1, 7, 102, 110, 144, 278, 279], "design": [0, 2, 7, 110, 111, 278, 279], "experiment": [0, 7, 20, 22, 50, 52, 64, 110, 111, 117, 134, 177, 213, 246, 278, 279], "factor": [0, 2, 7, 110, 111, 134, 135, 136, 137, 138, 139, 140, 141, 142, 279], "guid": [0, 2, 3, 4, 6, 7, 19, 20, 22, 49, 50, 52, 64, 110, 111, 116, 117, 156, 157, 159, 176, 177, 212, 213, 245, 246, 278], "tutori": [0, 1, 2, 3, 4, 6, 7, 110, 111], "formula": [0, 7, 110, 111, 278, 279], "numerator_valu": [0, 7, 110, 111], "denominator_valu": [0, 7, 110, 111], "what": [0, 3, 5, 7, 110, 111, 133, 189, 223, 257, 278], "element": [0, 2, 7, 10, 14, 16, 17, 18, 23, 30, 31, 33, 36, 40, 44, 46, 47, 48, 53, 60, 61, 66, 69, 110, 111, 145, 278], "fold": [0, 1, 2, 6, 7, 39, 72, 73, 74, 110, 111, 126, 167, 173, 181, 196, 203, 236, 242, 250, 260, 265, 278, 279], "chang": [0, 1, 6, 7, 13, 39, 43, 110, 111, 126, 167, 173, 181, 184, 196, 203, 236, 242, 250, 260, 265, 278, 279], "denomin": [0, 2, 7, 110, 111, 126, 236, 242, 250, 254, 260, 265, 278, 279], "differential_expression_limma_voom": [0, 2, 7], "limma": [0, 2, 6, 7, 111, 137, 279], "voom": [0, 2, 6, 7, 111], "drop": [0, 7, 35, 68, 102, 112, 164, 167, 172, 201, 204, 209, 234, 241, 270, 278, 279], "fro": [0, 7, 112, 172, 209, 241], "mthe": [0, 7, 112, 172, 209, 241], "enhanced_box_plot": [0, 2, 7], "enhanc": [0, 7, 113], "rpm": [0, 7, 113, 122, 129, 139, 140, 149, 154, 279], "filter_biotype_from_gtf": [0, 7], "lincrna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244, 279], "ncrna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244], "pirna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244, 279], "rrna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244], "snorna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244], "snrna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244], "trna": [0, 7, 114, 115, 174, 175, 210, 211, 243, 244], "anyth": [0, 7, 19, 20, 21, 49, 50, 51, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 143, 162, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 190, 199, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 224, 232, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 258, 268, 278], "BUT": [0, 7, 19, 20, 21, 49, 50, 51, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 143, 162, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 190, 199, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 224, 232, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 258, 268], "expect": [0, 7, 19, 20, 21, 29, 49, 50, 51, 59, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 143, 162, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 190, 199, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 224, 232, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 258, 260, 268, 278, 279], "filter_biotype_from_ref_t": [0, 2, 7, 260], "defin": [0, 2, 6, 7, 8, 19, 22, 29, 38, 49, 52, 59, 63, 64, 71, 75, 76, 115, 116, 175, 176, 211, 212, 244, 245], "whose": [0, 2, 7, 115, 120, 122, 123, 124, 132, 136, 145, 173, 175, 182, 183, 184, 211, 217, 218, 242, 244, 252, 278, 279], "13": [0, 7, 115, 150, 157, 175, 193, 211, 227, 244, 260, 262, 278, 279], "filter_by_attribut": [0, 2, 7, 260], "attribute1": [0, 7, 116, 151, 176, 194, 212, 228, 245, 260, 263, 279], "attr_ref_table_for_exampl": [0, 7, 116, 151, 176, 194, 212, 228, 245, 260, 263], "7": [0, 1, 3, 7, 116, 124, 130, 151, 152, 155, 176, 183, 187, 194, 195, 212, 218, 221, 228, 229, 245, 255, 260, 263, 278, 279], "OR": [0, 7, 116, 160, 176, 197, 212, 230, 245, 266], "attribute3": [0, 7, 116, 176, 212, 245, 279], "AND": [0, 7, 116, 176, 212, 245], "19": [0, 6, 7, 116, 155, 176, 212, 245, 279], "don": [0, 1, 2, 4, 5, 7, 116, 176, 212, 245, 278, 279], "filter_by_go_annot": [0, 2, 7], "go_id": [0, 7, 20, 50, 117, 177, 213, 246], "arabodopsi": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "thaliana": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "caenorhabd": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247, 278, 279], "elegan": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247, 278, 279], "danio": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "rerio": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "drosophila": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "melanogast": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "escherichia": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "coli": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "homo": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "sapien": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "mu": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "musculu": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "saccharomyc": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "cerevisia": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "schizosaccharomyc": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "pomb": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 117, 118, 177, 178, 213, 214, 246, 247], "gene_id_typ": [0, 7, 20, 21, 22, 28, 50, 51, 52, 58, 64, 65, 74, 117, 118, 177, 178, 213, 214, 246, 247, 279], "uniprotkb": [0, 5, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270, 279], "ac": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "uniparc": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "uniref50": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "uniref90": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "uniref100": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "crc64": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "ensembl": [0, 2, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 155, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270, 279], "protein": [0, 7, 20, 21, 22, 28, 29, 35, 38, 50, 51, 52, 58, 59, 64, 65, 68, 71, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 260, 270, 279], "geneid": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "kegg": [0, 2, 6, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270, 278], "patric": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "ucsc": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "wbparasit": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "arachnoserv": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "araport": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "cgd": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "conoserv": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "dictybas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "echobas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "euhcvdb": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "flybas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "genecard": [0, 5, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "genereview": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "hgnc": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "legiolist": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "leproma": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "maizegdb": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "mgi": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "mim": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "nextprot": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "opentarget": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "orphanet": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "pharmgkb": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "pombas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "pseudocap": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "rgd": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "sgd": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "tuberculist": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "veupathdb": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "vgnc": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "wormbas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270, 278, 279], "xenbas": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "zfin": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "eggnog": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "genetre": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "hogenom": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 234, 246, 247, 270], "oma": [0, 7, 20, 21, 22, 28, 35, 50, 51, 52, 58, 64, 65, 68, 74, 117, 118, 164, 177, 178, 201, 213, 214, 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do?": [[1, "i-get-an-error-message-when-i-try-to-install-the-rnalysis-randomization-feature-what-can-i-do"]], "I am trying to open RNAlysis for the first time and it takes a long time to load/doesn\u2019t load at all. What should I do?": [[1, "i-am-trying-to-open-rnalysis-for-the-first-time-and-it-takes-a-long-time-to-load-doesn-t-load-at-all-what-should-i-do"]], "Can I install a previous version of RNAlysis?": [[1, "can-i-install-a-previous-version-of-rnalysis"]], "Usage": [[1, "usage"]], "I am trying to view the RNAlysis quick-start guide, but see only blank pages. What should I do?": [[1, "i-am-trying-to-view-the-rnalysis-quick-start-guide-but-see-only-blank-pages-what-should-i-do"]], "I am trying to apply a function to my data table. How do I know what all the different functions and parmeters do?": [[1, "i-am-trying-to-apply-a-function-to-my-data-table-how-do-i-know-what-all-the-different-functions-and-parmeters-do"]], "I want to use a particular statistical method or algorithm available in RNAlysis. How do I know exactly what it does and how it works?": [[1, "i-want-to-use-a-particular-statistical-method-or-algorithm-available-in-rnalysis-how-do-i-know-exactly-what-it-does-and-how-it-works"]], "What file formats are supported by RNAlysis?": [[1, "what-file-formats-are-supported-by-rnalysis"]], "What types of tables can I analyze with RNAlysis?": [[1, "what-types-of-tables-can-i-analyze-with-rnalysis"]], "When trying to run clustering/enrichment/other functions in RNAlysis, a progress bar appears but nothing happens. What can I do?": [[1, "when-trying-to-run-clustering-enrichment-other-functions-in-rnalysis-a-progress-bar-appears-but-nothing-happens-what-can-i-do"]], "I ran into a problem that is not specified here. What can I do?": [[1, "i-ran-into-a-problem-that-is-not-specified-here-what-can-i-do"]], "Automatic analysis reports": [[1, "automatic-analysis-reports"]], "How can I generate an analysis report?": [[1, "how-can-i-generate-an-analysis-report"]], "How can I view an analysis report?": [[1, "how-can-i-view-an-analysis-report"]], "How can I share an analysis report?": [[1, "how-can-i-share-an-analysis-report"]], "How can I access the data and figures that appear in an analysis report?": [[1, "how-can-i-access-the-data-and-figures-that-appear-in-an-analysis-report"]], "Do I need to generate analysis reports manually?": [[1, "do-i-need-to-generate-analysis-reports-manually"]], "Can I edit my analysis report?": [[1, "can-i-edit-my-analysis-report"]], "RNAlysis crashed during an analysis! Can I restore my automatic analysis report?": [[1, "rnalysis-crashed-during-an-analysis-can-i-restore-my-automatic-analysis-report"]], "Can I create an analysis report through the programmatic interface?": [[1, "can-i-create-an-analysis-report-through-the-programmatic-interface"]], "RNAlysis quick-start video guide": [[5, "rnalysis-quick-start-video-guide"]], "Open the program": [[5, "open-the-program"]], "Load a table": [[5, "load-a-table"]], "Examine your table": [[5, "examine-your-table"]], "Filter your table": [[5, "filter-your-table"]], "Undo the operations you applied to your table": [[5, "undo-the-operations-you-applied-to-your-table"]], "Apply your operations \u2018in-place\u2019 or apply on a new table": [[5, "apply-your-operations-in-place-or-apply-on-a-new-table"]], "Save the changes you made to your table": [[5, "save-the-changes-you-made-to-your-table"]], "Work on multiple tables at the same time": [[5, "work-on-multiple-tables-at-the-same-time"]], "Different types of tables offer different ways to filter and analyze your data": [[5, "different-types-of-tables-offer-different-ways-to-filter-and-analyze-your-data"]], "Create and save graphs": [[5, "create-and-save-graphs"]], "Quickly look-up genes in your database of choice": [[5, "quickly-look-up-genes-in-your-database-of-choice"]], "Sort your tabs and change their icons": [[5, "sort-your-tabs-and-change-their-icons"]], "Restore tabs you closed": [[5, "restore-tabs-you-closed"]], "Import lists of genes as Gene Sets": [[5, "import-lists-of-genes-as-gene-sets"]], "Visualize the intersections between your tables and gene sets": [[5, "visualize-the-intersections-between-your-tables-and-gene-sets"]], "Apply set operations to your tables and gene sets": [[5, "apply-set-operations-to-your-tables-and-gene-sets"]], "Perform enrichment analysis on your tables and gene sets": [[5, "perform-enrichment-analysis-on-your-tables-and-gene-sets"]], "Create Pipelines to streamline your data analysis": [[5, "create-pipelines-to-streamline-your-data-analysis"]], "Apply Pipelines to one or more of your tables": [[5, "apply-pipelines-to-one-or-more-of-your-tables"]], "Export and share Pipelines to make your analysis more reproducible": [[5, "export-and-share-pipelines-to-make-your-analysis-more-reproducible"]], "Interface with other bioinformatic tools": [[5, "interface-with-other-bioinformatic-tools"]], "Create an interactive analysis report": [[5, "create-an-interactive-analysis-report"]], "What is RNAlysis?": [[6, "what-is-rnalysis"]], "What can I do with RNAlysis?": [[6, "what-can-i-do-with-rnalysis"]], "How do I install it?": [[6, "how-do-i-install-it"]], "How do I use it?": [[6, "how-do-i-use-it"]], "Dependencies": [[6, "dependencies"]], "Credits": [[6, "credits"]], "How do I cite RNAlysis?": [[6, "how-do-i-cite-rnalysis"]], "Development Lead": [[6, "development-lead"]], "Contributors": [[6, "contributors"]], "rnalysis.fastq": [[77, "rnalysis-fastq"]], 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\ No newline at end of file
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194, 198, 202, 207, 213, 230, 234, 237, 242, 247, 266, 271, 275, 280, 299, 300], "wbgene00007064": [0, 10, 110, 148, 153, 163, 168, 174, 194, 198, 202, 207, 213, 230, 234, 237, 242, 247, 266, 271, 275, 280, 299, 300], "wbgene00007066": [0, 10, 110, 148, 153, 163, 168, 174, 194, 198, 202, 207, 213, 230, 234, 237, 242, 247, 266, 271, 275, 280, 299, 300], "wbgene00007067": [0, 10, 110, 148, 153, 163, 168, 174, 194, 198, 202, 207, 213, 230, 234, 237, 242, 247, 266, 271, 275, 280, 299, 300], "wbgene00007069": [0, 10, 110, 148, 153, 163, 168, 174, 194, 198, 202, 207, 213, 230, 234, 237, 242, 247, 266, 271, 275, 280, 299, 300], "wbgene00007071": [0, 10, 110, 148, 163, 168, 174, 194, 202, 207, 213, 230, 237, 242, 247, 266, 275, 280, 299], "wbgene00007074": [0, 10, 110, 148, 163, 168, 174, 194, 202, 207, 213, 230, 237, 242, 247, 266, 275, 280, 299], "wbgene00007075": [0, 10, 110, 148, 163, 168, 174, 194, 202, 207, 213, 230, 237, 242, 247, 266, 275, 280, 299], "wbgene00007076": [0, 10, 110, 148, 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13, 16, 18, 19, 20, 25, 32, 33, 35, 38, 42, 45, 47, 48, 49, 54, 61, 62, 67, 70, 111, 112, 146, 298], "fold": [0, 2, 4, 5, 9, 10, 41, 73, 74, 75, 111, 112, 127, 170, 176, 184, 201, 208, 243, 249, 257, 267, 274, 298, 300], "chang": [0, 1, 2, 4, 9, 10, 15, 41, 44, 111, 112, 127, 170, 176, 184, 187, 201, 208, 243, 249, 257, 267, 274, 298, 300], "denomin": [0, 5, 10, 111, 112, 127, 243, 249, 257, 261, 267, 274, 298, 299, 300], "differential_expression_limma_voom": [0, 5, 10], "limma": [0, 5, 9, 10, 112, 138, 299, 300], "voom": [0, 5, 9, 10, 112], "drop": [0, 10, 37, 69, 103, 113, 167, 170, 175, 206, 209, 214, 241, 248, 279, 298, 300], "fro": [0, 10, 113, 175, 214, 248], "mthe": [0, 10, 113, 175, 214, 248], "enhanced_box_plot": [0, 5, 10], "enhanc": [0, 5, 10, 114], "rpm": [0, 10, 114, 123, 130, 140, 141, 152, 157, 299, 300], "filter_biotype_from_gtf": [0, 10], "lincrna": [0, 10, 115, 116, 177, 178, 215, 216, 250, 251, 299, 300], "ncrna": [0, 10, 115, 116, 177, 178, 215, 216, 250, 251], 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53, 59, 60, 65, 66, 72, 73, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 144, 165, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 193, 204, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 229, 239, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 265, 267, 277, 298, 299, 300], "filter_biotype_from_ref_t": [0, 4, 5, 10, 267, 299], "defin": [0, 4, 5, 9, 10, 11, 21, 24, 31, 40, 50, 53, 60, 64, 65, 72, 76, 77, 116, 117, 178, 179, 216, 217, 251, 252, 296, 297], "whose": [0, 5, 10, 116, 121, 123, 124, 125, 133, 137, 146, 176, 178, 185, 186, 187, 216, 222, 223, 249, 251, 259, 298, 299, 300], "13": [0, 10, 116, 153, 160, 178, 198, 216, 234, 251, 267, 271, 298, 299, 300], "filter_by_attribut": [0, 4, 5, 10, 267, 299], "attribute1": [0, 10, 117, 154, 179, 199, 217, 235, 252, 267, 272, 299, 300], "attr_ref_table_for_exampl": [0, 10, 117, 154, 179, 199, 217, 235, 252, 267, 272, 299], "7": [0, 1, 2, 6, 10, 117, 125, 131, 154, 155, 158, 179, 186, 190, 199, 200, 217, 223, 226, 235, 236, 252, 262, 267, 272, 298, 299, 300], "OR": [0, 10, 117, 163, 179, 202, 217, 237, 252, 275], "attribute3": [0, 10, 117, 179, 217, 252, 299, 300], "AND": [0, 10, 117, 179, 217, 252], "19": [0, 9, 10, 117, 158, 179, 217, 252, 299, 300], "don": [0, 2, 5, 7, 8, 10, 117, 179, 217, 252, 298, 299, 300], "filter_by_go_annot": [0, 5, 10], "go_id": [0, 10, 22, 51, 118, 180, 218, 253], "arabodopsi": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "thaliana": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "caenorhabd": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254, 298, 299, 300], "elegan": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254, 298, 300], "danio": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "rerio": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "drosophila": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "melanogast": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "escherichia": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "coli": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "homo": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "sapien": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "mu": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "musculu": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "saccharomyc": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "cerevisia": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "schizosaccharomyc": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "pomb": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 118, 119, 180, 181, 218, 219, 253, 254], "gene_id_typ": [0, 10, 22, 23, 24, 30, 51, 52, 53, 59, 65, 66, 75, 118, 119, 180, 181, 218, 219, 253, 254, 299, 300], "uniprotkb": [0, 8, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279, 299, 300], "ac": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "uniparc": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "uniref50": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "uniref90": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "uniref100": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "crc64": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "ensembl": [0, 5, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 158, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279, 299, 300], "protein": [0, 4, 10, 22, 23, 24, 30, 31, 37, 40, 51, 52, 53, 59, 60, 65, 66, 69, 72, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 267, 279, 299, 300], "geneid": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279], "kegg": [0, 5, 9, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 219, 241, 253, 254, 279, 298], "patric": [0, 10, 22, 23, 24, 30, 37, 51, 52, 53, 59, 65, 66, 69, 75, 118, 119, 167, 180, 181, 206, 218, 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"bowtie2": 299, "featurecount": 299, "object": 299, "initi": 299, "result": 299, "fold": 299, "exist": 299, "visualis": 299, "upset": 299, "path": 299, "pars": 299, "c": 299, "elegan": 299, "name": 299, "wbgene": 299, "regular": 299}, "envversion": {"sphinx.domains.c": 2, "sphinx.domains.changeset": 1, "sphinx.domains.citation": 1, "sphinx.domains.cpp": 8, "sphinx.domains.index": 1, "sphinx.domains.javascript": 2, "sphinx.domains.math": 2, "sphinx.domains.python": 3, "sphinx.domains.rst": 2, "sphinx.domains.std": 2, "sphinx": 57}, "alltitles": {"How can I contribute to RNAlysis?": [[1, "how-can-i-contribute-to-rnalysis"]], "Types of Contributions": [[1, "types-of-contributions"]], "Report Bugs": [[1, "report-bugs"]], "Fix Bugs": [[1, "fix-bugs"]], "Write Documentation": [[1, "write-documentation"]], "Submit Feedback": [[1, "submit-feedback"]], "Implement Features": [[1, "implement-features"]], "Ideas/To-Do": [[1, "ideas-to-do"]], "RNAlysis Design Philosophy": [[1, "rnalysis-design-philosophy"]], "Get Started!": [[1, "get-started"]], "Pull Request Guidelines": [[1, "pull-request-guidelines"]], "Tips": [[1, "tips"]], "Deploying": [[1, "deploying"]], "Frequently asked questions": [[2, "frequently-asked-questions"]], "Installation": [[2, "installation"], [7, "installation"]], "I get an error message when I try to install RNAlysis. what can I do?": [[2, "i-get-an-error-message-when-i-try-to-install-rnalysis-what-can-i-do"]], "I get an error message when I try to install the RNAlysis hdbscan feature. what can I do?": [[2, "i-get-an-error-message-when-i-try-to-install-the-rnalysis-hdbscan-feature-what-can-i-do"]], "I get an error message when I try to install the RNAlysis randomization feature. what can I do?": [[2, "i-get-an-error-message-when-i-try-to-install-the-rnalysis-randomization-feature-what-can-i-do"]], "I am trying to open RNAlysis for the first time and it takes a long time to load/doesn\u2019t load at all. What should I do?": [[2, "i-am-trying-to-open-rnalysis-for-the-first-time-and-it-takes-a-long-time-to-load-doesn-t-load-at-all-what-should-i-do"]], "Can I install a previous version of RNAlysis?": [[2, "can-i-install-a-previous-version-of-rnalysis"]], "Usage": [[2, "usage"]], "I am trying to view the RNAlysis quick-start guide, but see only blank pages. What should I do?": [[2, "i-am-trying-to-view-the-rnalysis-quick-start-guide-but-see-only-blank-pages-what-should-i-do"]], "I am trying to apply a function to my data table. How do I know what all the different functions and parmeters do?": [[2, "i-am-trying-to-apply-a-function-to-my-data-table-how-do-i-know-what-all-the-different-functions-and-parmeters-do"]], "I want to use a particular statistical method or algorithm available in RNAlysis. How do I know exactly what it does and how it works?": [[2, "i-want-to-use-a-particular-statistical-method-or-algorithm-available-in-rnalysis-how-do-i-know-exactly-what-it-does-and-how-it-works"]], "What file formats are supported by RNAlysis?": [[2, "what-file-formats-are-supported-by-rnalysis"]], "What types of tables can I analyze with RNAlysis?": [[2, "what-types-of-tables-can-i-analyze-with-rnalysis"]], "When trying to run clustering/enrichment/other functions in RNAlysis, a progress bar appears but nothing happens. What can I do?": [[2, "when-trying-to-run-clustering-enrichment-other-functions-in-rnalysis-a-progress-bar-appears-but-nothing-happens-what-can-i-do"]], "I ran into a problem that is not specified here. What can I do?": [[2, "i-ran-into-a-problem-that-is-not-specified-here-what-can-i-do"]], "Automatic analysis reports": [[2, "automatic-analysis-reports"]], "How can I generate an analysis report?": [[2, "how-can-i-generate-an-analysis-report"]], "How can I view an analysis report?": [[2, "how-can-i-view-an-analysis-report"]], "How can I share an analysis report?": [[2, "how-can-i-share-an-analysis-report"]], "How can I access the data and figures that appear in an analysis report?": [[2, "how-can-i-access-the-data-and-figures-that-appear-in-an-analysis-report"]], "Do I need to generate analysis reports manually?": [[2, "do-i-need-to-generate-analysis-reports-manually"]], "Can I edit my analysis report?": [[2, "can-i-edit-my-analysis-report"]], "RNAlysis crashed during an analysis! Can I restore my automatic analysis report?": [[2, "rnalysis-crashed-during-an-analysis-can-i-restore-my-automatic-analysis-report"]], "Can I create an analysis report through the programmatic interface?": [[2, "can-i-create-an-analysis-report-through-the-programmatic-interface"]], "Index": [[3, "index"]], "Glossary - programmatic interface": [[4, "glossary-programmatic-interface"]], "RNAlysis 3.9.0 documentation": [[6, "rnalysis-release-documentation"]], "About RNAlysis:": [[6, null]], "Starting with RNAlysis:": [[6, null]], "Change history:": [[6, null]], "Modules:": [[6, "modules"]], "Indices and tables:": [[6, null]], "RNAlysis stand-alone app (most beginner-friendly)": [[7, "rnalysis-stand-alone-app-most-beginner-friendly"]], "How to install it": [[7, "how-to-install-it"], [7, "id1"], [7, "id3"]], "How to run it": [[7, "how-to-run-it"], [7, "id2"], [7, "id4"]], "Further guidance": [[7, "further-guidance"]], "Install as a Python package with pip (best performance)": [[7, "install-as-a-python-package-with-pip-best-performance"]], "From sources": [[7, "from-sources"]], "RNAlysis quick-start video guide": [[8, "rnalysis-quick-start-video-guide"]], "Open the program": [[8, "open-the-program"]], "Load a table": [[8, "load-a-table"]], "Examine your table": [[8, "examine-your-table"]], "Filter your table": [[8, "filter-your-table"]], "Undo the operations you applied to your table": [[8, "undo-the-operations-you-applied-to-your-table"]], "Apply your operations \u2018in-place\u2019 or apply on a new table": [[8, "apply-your-operations-in-place-or-apply-on-a-new-table"]], "Save the changes you made to your table": [[8, "save-the-changes-you-made-to-your-table"]], "Work on multiple tables at the same time": [[8, "work-on-multiple-tables-at-the-same-time"]], "Different types of tables offer different ways to filter and analyze your data": [[8, "different-types-of-tables-offer-different-ways-to-filter-and-analyze-your-data"]], "Create and save graphs": [[8, "create-and-save-graphs"]], "Quickly look-up genes in your database of choice": [[8, "quickly-look-up-genes-in-your-database-of-choice"]], "Sort your tabs and change their icons": [[8, "sort-your-tabs-and-change-their-icons"]], "Restore tabs you closed": [[8, "restore-tabs-you-closed"]], "Import lists of genes as Gene Sets": [[8, "import-lists-of-genes-as-gene-sets"]], "Visualize the intersections between your tables and gene sets": [[8, "visualize-the-intersections-between-your-tables-and-gene-sets"]], "Apply set operations to your tables and gene sets": [[8, "apply-set-operations-to-your-tables-and-gene-sets"]], "Perform enrichment analysis on your tables and gene sets": [[8, "perform-enrichment-analysis-on-your-tables-and-gene-sets"]], "Create Pipelines to streamline your data analysis": [[8, "create-pipelines-to-streamline-your-data-analysis"]], "Apply Pipelines to one or more of your tables": [[8, "apply-pipelines-to-one-or-more-of-your-tables"]], "Export and share Pipelines to 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"rnalysis.general.clear_gui_cache": [[289, "rnalysis-general-clear-gui-cache"]], "rnalysis.general.parse_gene_name_string": [[290, "rnalysis-general-parse-gene-name-string"]], "rnalysis.general.parse_sequence_name_string": [[291, "rnalysis-general-parse-sequence-name-string"]], "rnalysis.general.parse_wbgene_string": [[292, "rnalysis-general-parse-wbgene-string"]], "rnalysis.general.print_settings_file": [[293, "rnalysis-general-print-settings-file"]], "rnalysis.general.reset_settings_file": [[294, "rnalysis-general-reset-settings-file"]], "rnalysis.general.save_to_csv": [[295, "rnalysis-general-save-to-csv"]], "rnalysis.general.set_attr_ref_table_path": [[296, "rnalysis-general-set-attr-ref-table-path"]], "rnalysis.general.set_biotype_ref_table_path": [[297, "rnalysis-general-set-biotype-ref-table-path"]], "A-to-Z tutorial - example analysis": [[298, "a-to-z-tutorial-example-analysis"]], "Intro and recommendations": [[298, "intro-and-recommendations"]], "Analysis #1 - time series RNA sequencing": [[298, "analysis-1-time-series-rna-sequencing"]], "The dataset": [[298, "the-dataset"], [298, "id6"]], "Start RNAlysis": [[298, "start-rnalysis"]], "Data preprocessing and exploratory data analysis": [[298, "data-preprocessing-and-exploratory-data-analysis"]], "Filter out lowly-expressed genes": [[298, "filter-out-lowly-expressed-genes"]], "Examine variance in our data with Principal Component Analysis": [[298, "examine-variance-in-our-data-with-principal-component-analysis"]], "Examine similarity between developmental stages": [[298, "examine-similarity-between-developmental-stages"]], "Compare the expression of specific genes over the developmental stages": [[298, "compare-the-expression-of-specific-genes-over-the-developmental-stages"]], "Clustering analysis": [[298, "clustering-analysis"]], "The simple approach - distance-based clustering with K-Medoids": [[298, "the-simple-approach-distance-based-clustering-with-k-medoids"]], "Fine-tuning our approach - density-based 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 <h1>A-to-Z tutorial - example analysis<a class="headerlink" href="#a-to-z-tutorial-example-analysis" title="Permalink to this heading"></a></h1>
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 </body>
-</html>
+</html>
\ No newline at end of file
diff --git a/docs/build/user_guide_gui.html b/docs/build/user_guide_gui.html
index 3b63976a..14d3f05d 100644
--- a/docs/build/user_guide_gui.html
+++ b/docs/build/user_guide_gui.html
@@ -4,7 +4,7 @@
   <meta charset="utf-8" /><meta name="generator" content="Docutils 0.17.1: http://docutils.sourceforge.net/" />
 
   <meta name="viewport" content="width=device-width, initial-scale=1.0" />
-  <title>User guide - graphical interface &mdash; RNAlysis 3.8.0 documentation</title>
+  <title>User guide - graphical interface &mdash; RNAlysis 3.9.0 documentation</title>
       <link rel="stylesheet" href="_static/pygments.css" type="text/css" />
       <link rel="stylesheet" href="_static/css/theme.css" type="text/css" />
     <link rel="shortcut icon" href="_static/favicon.ico"/>
diff --git a/docs/source/rnalysis.filtering.CountFilter.rst b/docs/source/rnalysis.filtering.CountFilter.rst
index db8c5bac..fed55fcb 100644
--- a/docs/source/rnalysis.filtering.CountFilter.rst
+++ b/docs/source/rnalysis.filtering.CountFilter.rst
@@ -1,4 +1,4 @@
-rnalysis.filtering.CountFilter
+rnalysis.filtering.CountFilter
 ==============================
 
 .. currentmodule:: rnalysis.filtering
@@ -62,6 +62,8 @@ rnalysis.filtering.CountFilter
     CountFilter.plot_expression
     CountFilter.print_features
     CountFilter.save_csv
+    CountFilter.save_parquet
+    CountFilter.save_table
     CountFilter.scatter_sample_vs_sample
     CountFilter.sort
     CountFilter.split_by_attribute
diff --git a/docs/source/rnalysis.filtering.CountFilter.save_parquet.rst b/docs/source/rnalysis.filtering.CountFilter.save_parquet.rst
new file mode 100644
index 00000000..00e2b205
--- /dev/null
+++ b/docs/source/rnalysis.filtering.CountFilter.save_parquet.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.CountFilter.save\_parquet
+============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: CountFilter.save_parquet
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.CountFilter.save_table.rst b/docs/source/rnalysis.filtering.CountFilter.save_table.rst
new file mode 100644
index 00000000..7aa50788
--- /dev/null
+++ b/docs/source/rnalysis.filtering.CountFilter.save_table.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.CountFilter.save\_table
+==========================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: CountFilter.save_table
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.DESeqFilter.rst b/docs/source/rnalysis.filtering.DESeqFilter.rst
index 1b99dd11..656b060d 100644
--- a/docs/source/rnalysis.filtering.DESeqFilter.rst
+++ b/docs/source/rnalysis.filtering.DESeqFilter.rst
@@ -1,4 +1,4 @@
-rnalysis.filtering.DESeqFilter
+rnalysis.filtering.DESeqFilter
 ==============================
 
 .. currentmodule:: rnalysis.filtering
@@ -41,6 +41,8 @@ rnalysis.filtering.DESeqFilter
     DESeqFilter.number_filters
     DESeqFilter.print_features
     DESeqFilter.save_csv
+    DESeqFilter.save_parquet
+    DESeqFilter.save_table
     DESeqFilter.sort
     DESeqFilter.split_by_attribute
     DESeqFilter.split_by_percentile
diff --git a/docs/source/rnalysis.filtering.DESeqFilter.save_parquet.rst b/docs/source/rnalysis.filtering.DESeqFilter.save_parquet.rst
new file mode 100644
index 00000000..d1c56fee
--- /dev/null
+++ b/docs/source/rnalysis.filtering.DESeqFilter.save_parquet.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.DESeqFilter.save\_parquet
+============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: DESeqFilter.save_parquet
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.DESeqFilter.save_table.rst b/docs/source/rnalysis.filtering.DESeqFilter.save_table.rst
new file mode 100644
index 00000000..60b8bc05
--- /dev/null
+++ b/docs/source/rnalysis.filtering.DESeqFilter.save_table.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.DESeqFilter.save\_table
+==========================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: DESeqFilter.save_table
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.Filter.rst b/docs/source/rnalysis.filtering.Filter.rst
index 9d19e05b..6c7829d7 100644
--- a/docs/source/rnalysis.filtering.Filter.rst
+++ b/docs/source/rnalysis.filtering.Filter.rst
@@ -1,4 +1,4 @@
-rnalysis.filtering.Filter
+rnalysis.filtering.Filter
 =========================
 
 .. currentmodule:: rnalysis.filtering
@@ -38,6 +38,8 @@ rnalysis.filtering.Filter
     Filter.number_filters
     Filter.print_features
     Filter.save_csv
+    Filter.save_parquet
+    Filter.save_table
     Filter.sort
     Filter.split_by_attribute
     Filter.split_by_percentile
diff --git a/docs/source/rnalysis.filtering.Filter.save_parquet.rst b/docs/source/rnalysis.filtering.Filter.save_parquet.rst
new file mode 100644
index 00000000..ba7cba54
--- /dev/null
+++ b/docs/source/rnalysis.filtering.Filter.save_parquet.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.Filter.save\_parquet
+=======================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: Filter.save_parquet
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.Filter.save_table.rst b/docs/source/rnalysis.filtering.Filter.save_table.rst
new file mode 100644
index 00000000..6687c006
--- /dev/null
+++ b/docs/source/rnalysis.filtering.Filter.save_table.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.Filter.save\_table
+=====================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: Filter.save_table
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.FoldChangeFilter.rst b/docs/source/rnalysis.filtering.FoldChangeFilter.rst
index 12df8225..b083a6b3 100644
--- a/docs/source/rnalysis.filtering.FoldChangeFilter.rst
+++ b/docs/source/rnalysis.filtering.FoldChangeFilter.rst
@@ -1,4 +1,4 @@
-rnalysis.filtering.FoldChangeFilter
+rnalysis.filtering.FoldChangeFilter
 ===================================
 
 .. currentmodule:: rnalysis.filtering
@@ -41,6 +41,8 @@ rnalysis.filtering.FoldChangeFilter
     FoldChangeFilter.print_features
     FoldChangeFilter.randomization_test
     FoldChangeFilter.save_csv
+    FoldChangeFilter.save_parquet
+    FoldChangeFilter.save_table
     FoldChangeFilter.sort
     FoldChangeFilter.split_by_attribute
     FoldChangeFilter.split_by_percentile
diff --git a/docs/source/rnalysis.filtering.FoldChangeFilter.save_parquet.rst b/docs/source/rnalysis.filtering.FoldChangeFilter.save_parquet.rst
new file mode 100644
index 00000000..b4926620
--- /dev/null
+++ b/docs/source/rnalysis.filtering.FoldChangeFilter.save_parquet.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.FoldChangeFilter.save\_parquet
+=================================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: FoldChangeFilter.save_parquet
\ No newline at end of file
diff --git a/docs/source/rnalysis.filtering.FoldChangeFilter.save_table.rst b/docs/source/rnalysis.filtering.FoldChangeFilter.save_table.rst
new file mode 100644
index 00000000..ff9f1599
--- /dev/null
+++ b/docs/source/rnalysis.filtering.FoldChangeFilter.save_table.rst
@@ -0,0 +1,6 @@
+rnalysis.filtering.FoldChangeFilter.save\_table
+===============================================
+
+.. currentmodule:: rnalysis.filtering
+
+.. automethod:: FoldChangeFilter.save_table
\ No newline at end of file